STRINGSTRING
TP53 TP53 HGF HGF EGFR EGFR FGF20 FGF20 PDGFA PDGFA E2F1 E2F1 AKT2 AKT2 MDM2 MDM2 FGF2 FGF2 PIK3CA PIK3CA RAF1 RAF1 M3YZX8_MUSPF M3YZX8_MUSPF MITF MITF FGF8 FGF8 CDKN2A CDKN2A E2F2 E2F2 AKT3 AKT3 M3YWA8_MUSPF M3YWA8_MUSPF PIK3R1 PIK3R1 FGF10 FGF10 CDKN1A CDKN1A PDGFRB PDGFRB ARAF ARAF PDGFB PDGFB PPP1R14B PPP1R14B M3YNJ8_MUSPF M3YNJ8_MUSPF BAD BAD FGF18 FGF18 MAPK3 MAPK3 FGF7 FGF7 GALK2 GALK2 IGF1 IGF1 IGF1R IGF1R M3YH29_MUSPF M3YH29_MUSPF KRAS KRAS FGF22 FGF22 FGFR1 FGFR1 FGF23 FGF23 FGF6 FGF6 PIK3CB PIK3CB EGF EGF GADD45G GADD45G CDK6 CDK6 FGF1 FGF1 MET MET CDH1 CDH1 M3Y696_MUSPF M3Y696_MUSPF GADD45B GADD45B FGF5 FGF5 PDGFD PDGFD PIK3CD PIK3CD PDGFRA PDGFRA CSDE1 CSDE1 PDGFC PDGFC M3Y2Z6_MUSPF M3Y2Z6_MUSPF POLK POLK E2F3 E2F3 DDB2 DDB2 M3Y027_MUSPF M3Y027_MUSPF M3XZV6_MUSPF M3XZV6_MUSPF FGF4 FGF4 FGF19 FGF19 CCND1 CCND1 FGF17 FGF17 FGF21 FGF21 BRAF BRAF BAX BAX MAPK1 MAPK1 BAK1 BAK1 AKT1 AKT1 CDK4 CDK4 RB1 RB1 GADD45A GADD45A FGF9 FGF9 MAP2K1 MAP2K1 FGF16 FGF16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
E2F1E2F transcription factor 1. (354 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
M3YZX8_MUSPFUncharacterized protein. (144 aa)
MITFMelanocyte inducing transcription factor. (520 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (152 aa)
E2F2E2F transcription factor 2. (440 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1137 aa)
ARAFV-raf murine sarcoma 3611 viral oncoprotein-like protein. (606 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (242 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
BADBCL2 associated agonist of cell death. (168 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GALK2Galactokinase 2. (447 aa)
IGF1Insulin like growth factor 1. (153 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
FGFR1Fibroblast growth factor receptor. (856 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1540 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
M3Y696_MUSPFUncharacterized protein. (492 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (265 aa)
PDGFDPlatelet derived growth factor D. (364 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
CSDE1Cold shock domain containing E1. (784 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
POLKDNA polymerase kappa. (870 aa)
E2F3E2F transcription factor 3. (340 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
M3XZV6_MUSPFFibroblast growth factor; Belongs to the heparin-binding growth factors family. (153 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (715 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (305 aa)
RB1RB transcriptional corepressor 1. (948 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.