STRINGSTRING
MAP2K1 MAP2K1 GADD45A GADD45A RB1 RB1 CDK4 CDK4 AKT1 AKT1 RXRB RXRB BAK1 BAK1 MAPK1 MAPK1 BAX BAX BRAF BRAF RXRG RXRG CCND1 CCND1 M3Y027_MUSPF M3Y027_MUSPF DDB2 DDB2 E2F3 E2F3 SOS2 SOS2 POLK POLK M3Y2Z6_MUSPF M3Y2Z6_MUSPF CSDE1 CSDE1 PIK3CD PIK3CD GADD45B GADD45B MET MET TGFA TGFA CDK6 CDK6 GADD45G GADD45G EGF EGF EML4 EML4 TP53 TP53 PIK3CB PIK3CB PLCG2 PLCG2 FOXO3 FOXO3 PRKCG PRKCG KRAS KRAS SOS1 SOS1 STAT3 STAT3 STAT5A STAT5A STAT5B STAT5B M3YH29_MUSPF M3YH29_MUSPF RASSF5 RASSF5 RARB RARB RXRA RXRA PRKCB PRKCB MAPK3 MAPK3 BAD BAD M3YNJ8_MUSPF M3YNJ8_MUSPF RASSF1 RASSF1 PPP1R14B PPP1R14B ARAF ARAF GRB2 GRB2 CDKN1A CDKN1A PRKCA PRKCA PIK3R1 PIK3R1 ERBB2 ERBB2 PDPK1 PDPK1 M3YWA8_MUSPF M3YWA8_MUSPF AKT3 AKT3 JAK3 JAK3 E2F2 E2F2 CDKN2A CDKN2A CASP9 CASP9 RAF1 RAF1 PIK3CA PIK3CA STK4 STK4 PLCG1 PLCG1 AKT2 AKT2 E2F1 E2F1 ALK ALK EGFR EGFR HGF HGF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
RB1RB transcriptional corepressor 1. (948 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (305 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RXRBRetinoid X receptor beta. (532 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (715 aa)
RXRGRetinoid X receptor gamma. (463 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
E2F3E2F transcription factor 3. (340 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1281 aa)
POLKDNA polymerase kappa. (870 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
CSDE1Cold shock domain containing E1. (784 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1540 aa)
TGFATransforming growth factor alpha. (158 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
EML4EMAP like 4. (992 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
FOXO3Forkhead box O3. (671 aa)
PRKCGNon-specific serine/threonine protein kinase. (569 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT5BSignal transducer and activator of transcription. (691 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
RASSF5Ras association domain family member 5. (266 aa)
RARBRetinoic acid receptor beta. (448 aa)
RXRARetinoid X receptor alpha. (548 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (577 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
BADBCL2 associated agonist of cell death. (168 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
RASSF1Ras association domain family member 1. (272 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
ARAFV-raf murine sarcoma 3611 viral oncoprotein-like protein. (606 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
JAK3Tyrosine-protein kinase. (1107 aa)
E2F2E2F transcription factor 2. (440 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (152 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
STK4Serine/threonine kinase 4. (487 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
E2F1E2F transcription factor 1. (354 aa)
ALKTyrosine-protein kinase receptor. (1633 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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