STRINGSTRING
WNT9A WNT9A WNT3A WNT3A FZD3 FZD3 MYC MYC NOTCH2 NOTCH2 RB1 RB1 TNFSF11 TNFSF11 PGR PGR HEY1 HEY1 BRCA2 BRCA2 CDK4 CDK4 TCF7L2 TCF7L2 M3XSG3_MUSPF M3XSG3_MUSPF JUN JUN LOC106003358 LOC106003358 M3Z6K8_MUSPF M3Z6K8_MUSPF FZD1 FZD1 FZD2 FZD2 FZD5 FZD5 FZD7 FZD7 EGFR EGFR WNT5B WNT5B FGF20 FGF20 E2F1 E2F1 DLL3 DLL3 AKT2 AKT2 NCOA3 NCOA3 FGF2 FGF2 WNT7A WNT7A PIK3CA PIK3CA RAF1 RAF1 FRAT2 FRAT2 M3YZX8_MUSPF M3YZX8_MUSPF WNT8B WNT8B FGF8 FGF8 NFKB2 NFKB2 WNT5A WNT5A WNT10A WNT10A WNT6 WNT6 MTOR MTOR WNT7B WNT7B NOTCH3 NOTCH3 AXIN1 AXIN1 WNT4 WNT4 E2F2 E2F2 AKT3 AKT3 M3YWA8_MUSPF M3YWA8_MUSPF RPS6KB1 RPS6KB1 FZD6 FZD6 ERBB2 ERBB2 WNT10B WNT10B WNT1 WNT1 PIK3R1 PIK3R1 AXIN2 AXIN2 NCOA7 NCOA7 M3YSW1_MUSPF M3YSW1_MUSPF HEYL HEYL FGF10 FGF10 DVL1 DVL1 CSNK1A1 CSNK1A1 CDKN1A CDKN1A NCOA1 NCOA1 GRB2 GRB2 ARAF ARAF M3YNJ8_MUSPF M3YNJ8_MUSPF FGF18 FGF18 APC APC MAPK3 MAPK3 FGF7 FGF7 GALK2 GALK2 SHC4 SHC4 IGF1 IGF1 LRP6 LRP6 CTNNB1 CTNNB1 M3XSG7_MUSPF M3XSG7_MUSPF M3XSG8_MUSPF M3XSG8_MUSPF AKT1 AKT1 BAK1 BAK1 DVL3 DVL3 M3XVK5_MUSPF M3XVK5_MUSPF M3XVL1_MUSPF M3XVL1_MUSPF MAPK1 MAPK1 M3XVL3_MUSPF M3XVL3_MUSPF M3XVL5_MUSPF M3XVL5_MUSPF BAX BAX BRAF BRAF HES1 HES1 FGF21 FGF21 RPS6KB2 RPS6KB2 FGF17 FGF17 LRP5 LRP5 FZD10 FZD10 CCND1 CCND1 FGF19 FGF19 FGF4 FGF4 M3XZV6_MUSPF M3XZV6_MUSPF M3Y027_MUSPF M3Y027_MUSPF DDB2 DDB2 E2F3 E2F3 WNT2B WNT2B SOS2 SOS2 POLK POLK M3Y2Z6_MUSPF M3Y2Z6_MUSPF CSDE1 CSDE1 SP1 SP1 KIT KIT SHC1 SHC1 PIK3CD PIK3CD JAG1 JAG1 FGF5 FGF5 GADD45B GADD45B ESR2 ESR2 LOC101676235 LOC101676235 WNT16 WNT16 DLL1 DLL1 WNT2 WNT2 FGF1 FGF1 APC2 APC2 WNT3 WNT3 WNT9B WNT9B CDK6 CDK6 GSK3B GSK3B GADD45G GADD45G SHC3 SHC3 EGF EGF TCF7L1 TCF7L1 DLL4 DLL4 WNT11 WNT11 LEF1 LEF1 TP53 TP53 PIK3CB PIK3CB FOS FOS FGF6 FGF6 FGF23 FGF23 FGFR1 FGFR1 WNT8A WNT8A M3YEG5_MUSPF M3YEG5_MUSPF FGF22 FGF22 SHC2 SHC2 NOTCH4 NOTCH4 TCF7 TCF7 KRAS KRAS FZD4 FZD4 CCDC170 CCDC170 SOS1 SOS1 ESR1 ESR1 DVL2 DVL2 M3YH29_MUSPF M3YH29_MUSPF IGF1R IGF1R NOTCH1 NOTCH1 FGF16 FGF16 MAP2K1 MAP2K1 FLT4 FLT4 FGF9 FGF9 GADD45A GADD45A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (451 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
MYCV-myc myelocytomatosis viral oncoprotein-like protein. (453 aa)
NOTCH2Notch receptor 2. (2471 aa)
RB1RB transcriptional corepressor 1. (948 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
PGRProgesterone receptor. (934 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
BRCA2BRCA2 DNA repair associated. (3466 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (305 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
M3XSG3_MUSPFCTNNB1_binding domain-containing protein. (169 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
LOC106003358Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (544 aa)
M3Z6K8_MUSPFG_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family. (397 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (642 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (602 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (406 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
E2F1E2F transcription factor 1. (354 aa)
DLL3Delta like canonical Notch ligand 3. (590 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NCOA3Nuclear receptor coactivator. (1416 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
FRAT2FRAT regulator of WNT signaling pathway 2. (191 aa)
M3YZX8_MUSPFUncharacterized protein. (144 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (383 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
NOTCH3Notch receptor 3. (2305 aa)
AXIN1Axin 1. (862 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
E2F2E2F transcription factor 2. (440 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (736 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
AXIN2Axin 2. (842 aa)
NCOA7Nuclear receptor coactivator 7. (970 aa)
M3YSW1_MUSPFBHLH domain-containing protein. (111 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
DVL1Dishevelled segment polarity protein 1. (691 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (365 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
NCOA1Nuclear receptor coactivator. (1399 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ARAFV-raf murine sarcoma 3611 viral oncoprotein-like protein. (606 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
APCAPC regulator of WNT signaling pathway. (2862 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GALK2Galactokinase 2. (447 aa)
SHC4SHC adaptor protein 4. (624 aa)
IGF1Insulin like growth factor 1. (153 aa)
LRP6LDL receptor related protein 6. (1462 aa)
CTNNB1Catenin beta 1. (781 aa)
M3XSG7_MUSPFUncharacterized protein. (233 aa)
M3XSG8_MUSPFUncharacterized protein. (429 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
M3XVK5_MUSPFUncharacterized protein. (1274 aa)
M3XVL1_MUSPFUncharacterized protein. (68 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
M3XVL3_MUSPFUncharacterized protein. (168 aa)
M3XVL5_MUSPFUncharacterized protein. (105 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (715 aa)
HES1Hes family bHLH transcription factor 1. (283 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (479 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
LRP5Uncharacterized protein. (1465 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
M3XZV6_MUSPFFibroblast growth factor; Belongs to the heparin-binding growth factors family. (153 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
E2F3E2F transcription factor 3. (340 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1281 aa)
POLKDNA polymerase kappa. (870 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
CSDE1Cold shock domain containing E1. (784 aa)
SP1Sp1 transcription factor. (787 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (948 aa)
SHC1SHC adaptor protein 1. (586 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (265 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
ESR2Estrogen receptor 2. (521 aa)
LOC101676235Uncharacterized protein. (531 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (602 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
APC2APC regulator of WNT signaling pathway 2. (2481 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
SHC3SHC adaptor protein 3. (425 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
TCF7L1Transcription factor 7 like 1. (490 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LEF1Lymphoid enhancer binding factor 1. (400 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
FGFR1Fibroblast growth factor receptor. (856 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
M3YEG5_MUSPFBreast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (766 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
SHC2Uncharacterized protein. (539 aa)
NOTCH4Notch receptor 4. (1993 aa)
TCF7Transcription factor 7. (339 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
CCDC170Coiled-coil domain containing 170. (701 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (597 aa)
DVL2Dishevelled segment polarity protein 2. (734 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
NOTCH1Notch receptor 1. (2119 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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