STRINGSTRING
IDH1 IDH1 SCO2 SCO2 LOC101679751 LOC101679751 PGAM2 PGAM2 GCK GCK EGFR EGFR AKT2 AKT2 M3Z1K7_MUSPF M3Z1K7_MUSPF RET RET PIK3CA PIK3CA RAF1 RAF1 TNIK TNIK PARP6 PARP6 PKM PKM SLC2A2 SLC2A2 PGAM1 PGAM1 M3YZX8_MUSPF M3YZX8_MUSPF PDHB PDHB MTOR MTOR PFKP PFKP NTRK3 NTRK3 IDH2 IDH2 AKT3 AKT3 M3YWA8_MUSPF M3YWA8_MUSPF ERBB2 ERBB2 PIK3R1 PIK3R1 M3YSQ8_MUSPF M3YSQ8_MUSPF PARP8 PARP8 PDGFRB PDGFRB SLC2A1 SLC2A1 M3YQQ4_MUSPF M3YQQ4_MUSPF M3YQL8_MUSPF M3YQL8_MUSPF M3YNJ8_MUSPF M3YNJ8_MUSPF MAPK3 MAPK3 GLS GLS HK3 HK3 SLC16A3 SLC16A3 FGFR3 FGFR3 M3YH29_MUSPF M3YH29_MUSPF KRAS KRAS PFKL PFKL G6PD G6PD FGFR1 FGFR1 TIGAR TIGAR PIK3CB PIK3CB TP53 TP53 SIRT3 SIRT3 SLC7A5 SLC7A5 HK2 HK2 MET MET M3Y5C5_MUSPF M3Y5C5_MUSPF HIF1A HIF1A PIK3CD PIK3CD KIT KIT PDGFRA PDGFRA CSDE1 CSDE1 M3Y2Z6_MUSPF M3Y2Z6_MUSPF SLC1A5 SLC1A5 FLT3 FLT3 SIRT6 SIRT6 M3Y027_MUSPF M3Y027_MUSPF M3XZF1_MUSPF M3XZF1_MUSPF HKDC1 HKDC1 HK1 HK1 M3XXB0_MUSPF M3XXB0_MUSPF SCO1 SCO1 NTRK1 NTRK1 PDHA1 PDHA1 MAPK1 MAPK1 FGFR2 FGFR2 AKT1 AKT1 GLS2 GLS2 MYC MYC PDK1 PDK1 PFKM PFKM MAP2K1 MAP2K1 G9K812_MUSPF G9K812_MUSPF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
SCO2SCO cytochrome c oxidase assembly protein 2. (266 aa)
LOC101679751L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
GCKPhosphotransferase. (473 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
M3Z1K7_MUSPFL-lactate dehydrogenase. (242 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1028 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
TNIKTRAF2 and NCK interacting kinase. (1360 aa)
PARP6Poly [ADP-ribose] polymerase. (741 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (579 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (508 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
M3YZX8_MUSPFUncharacterized protein. (144 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (790 aa)
NTRK3Tyrosine-protein kinase receptor. (781 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (451 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
M3YSQ8_MUSPFUncharacterized protein; Belongs to the LDH/MDH superfamily. (312 aa)
PARP8Poly [ADP-ribose] polymerase. (893 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1137 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (480 aa)
M3YQQ4_MUSPFL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (230 aa)
M3YQL8_MUSPFL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (385 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
GLSGlutaminase. (541 aa)
HK3Hexokinase 3. (924 aa)
SLC16A3Solute carrier family 16 member 3. (460 aa)
FGFR3Fibroblast growth factor receptor. (802 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (751 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (545 aa)
FGFR1Fibroblast growth factor receptor. (856 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (373 aa)
SLC7A5Solute carrier family 7 member 5. (340 aa)
HK2Hexokinase 2. (917 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1540 aa)
M3Y5C5_MUSPFUncharacterized protein; Belongs to the LDH/MDH superfamily. (293 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (824 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (948 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
CSDE1Cold shock domain containing E1. (784 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
SLC1A5Amino acid transporter. (541 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
SIRT6Sirtuin 6. (359 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
M3XZF1_MUSPFPhosphotransferase. (133 aa)
HKDC1Hexokinase domain containing 1. (704 aa)
HK1Hexokinase 1. (917 aa)
M3XXB0_MUSPFLdh_1_N domain-containing protein. (275 aa)
SCO1SCO cytochrome c oxidase assembly protein 1. (294 aa)
NTRK1Tyrosine-protein kinase receptor. (727 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (389 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
FGFR2Fibroblast growth factor receptor. (842 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GLS2Glutaminase 2. (602 aa)
MYCV-myc myelocytomatosis viral oncoprotein-like protein. (453 aa)
PDK1Protein-serine/threonine kinase. (378 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (782 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
G9K812_MUSPFL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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