STRINGSTRING
IFNG IFNG NFATC2 NFATC2 PLCG1 PLCG1 AKT2 AKT2 NFKBIB NFKBIB M3Z2K4_MUSPF M3Z2K4_MUSPF MAPK11 MAPK11 AKT1 AKT1 TLR4 TLR4 IFNGR2 IFNGR2 TMED7 TMED7 JAK1 JAK1 CD28 CD28 MAP2K1 MAP2K1 PDCD1 PDCD1 MAP2K3 MAP2K3 ALK ALK EGFR EGFR TLR2 TLR2 M3Z7C0_MUSPF M3Z7C0_MUSPF JUN JUN PTPN11 PTPN11 MYD88 MYD88 MAPK1 MAPK1 PPP3CB PPP3CB PPP3CC PPP3CC RPS6KB2 RPS6KB2 MAPK14 MAPK14 MAPK13 MAPK13 CD3E CD3E CD3D CD3D CD3G CD3G CSNK2A2 CSNK2A2 M3Y027_MUSPF M3Y027_MUSPF CD274 CD274 JAK2 JAK2 TICAM1 TICAM1 M3Y2Z6_MUSPF M3Y2Z6_MUSPF CSDE1 CSDE1 PIK3CD PIK3CD M3Y4E6_MUSPF M3Y4E6_MUSPF HIF1A HIF1A TIRAP TIRAP NFATC3 NFATC3 M3Y7D3_MUSPF M3Y7D3_MUSPF M3Y7K5_MUSPF M3Y7K5_MUSPF TRAV18 TRAV18 M3YA49_MUSPF M3YA49_MUSPF M3YA60_MUSPF M3YA60_MUSPF M3YAT2_MUSPF M3YAT2_MUSPF M3YAV2_MUSPF M3YAV2_MUSPF TRBV25-1 TRBV25-1 EGF EGF M3YAY8_MUSPF M3YAY8_MUSPF M3YAZ8_MUSPF M3YAZ8_MUSPF M3YB13_MUSPF M3YB13_MUSPF EML4 EML4 PIK3CB PIK3CB BATF BATF FOS FOS NFKB1 NFKB1 PPP3CA PPP3CA IKBKG IKBKG KRAS KRAS STAT3 STAT3 M3YH29_MUSPF M3YH29_MUSPF M3YI82_MUSPF M3YI82_MUSPF ZAP70 ZAP70 RELA RELA M3YJV8_MUSPF M3YJV8_MUSPF TRAF6 TRAF6 M3YLR8_MUSPF M3YLR8_MUSPF BATF2 BATF2 STAT1 STAT1 NFKBIE NFKBIE MAPK3 MAPK3 IKBKB IKBKB LAT LAT M3YNJ8_MUSPF M3YNJ8_MUSPF BATF3 BATF3 M3YR72_MUSPF M3YR72_MUSPF MAP2K6 MAP2K6 PIK3R1 PIK3R1 IFNGR1 IFNGR1 MAP3K3 MAP3K3 RPS6KB1 RPS6KB1 LCK LCK CD247 CD247 M3YWA8_MUSPF M3YWA8_MUSPF AKT3 AKT3 NFKBIA NFKBIA PRKCQ PRKCQ MTOR MTOR NFATC1 NFATC1 PTPN6 PTPN6 CD4 CD4 CHUK CHUK MAPK12 MAPK12 M3YZX8_MUSPF M3YZX8_MUSPF RAF1 RAF1 PIK3CA PIK3CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
NFATC2Nuclear factor of activated T cells 2. (912 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
M3Z2K4_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
MAPK11Mitogen-activated protein kinase. (434 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
IFNGR2Interferon gamma receptor 2. (341 aa)
TMED7GOLD domain-containing protein. (224 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
CD28CD28 molecule. (255 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PDCD1Programmed cell death 1. (288 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (396 aa)
ALKTyrosine-protein kinase receptor. (1633 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
M3Z7C0_MUSPFCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
PPP3CBSerine/threonine-protein phosphatase. (479 aa)
PPP3CCSerine/threonine-protein phosphatase. (525 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (479 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CD3ECD3 epsilon antigen. (186 aa)
CD3DCD3d molecule. (169 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (180 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (326 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
CD274CD274 molecule. (303 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (689 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
CSDE1Cold shock domain containing E1. (784 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
M3Y4E6_MUSPFUncharacterized protein. (160 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (824 aa)
TIRAPTIR domain containing adaptor protein. (227 aa)
NFATC3Nuclear factor of activated T cells 3. (1037 aa)
M3Y7D3_MUSPFDUF1968 domain-containing protein. (157 aa)
M3Y7K5_MUSPFIg-like domain-containing protein. (163 aa)
TRAV18T cell receptor alpha variable 18. (159 aa)
M3YA49_MUSPFUncharacterized protein. (659 aa)
M3YA60_MUSPFN-terminal Ras-GEF domain-containing protein. (178 aa)
M3YAT2_MUSPFIg-like domain-containing protein. (186 aa)
M3YAV2_MUSPFIg-like domain-containing protein. (141 aa)
TRBV25-1T cell receptor beta variable 25-1. (125 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
M3YAY8_MUSPFIg-like domain-containing protein. (227 aa)
M3YAZ8_MUSPFIg-like domain-containing protein. (158 aa)
M3YB13_MUSPFIg-like domain-containing protein. (159 aa)
EML4EMAP like 4. (992 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (412 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
M3YI82_MUSPFCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
ZAP70Tyrosine-protein kinase. (616 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
M3YJV8_MUSPFUncharacterized protein. (1327 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
M3YLR8_MUSPFRHD domain-containing protein. (249 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (275 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
NFKBIENFKB inhibitor epsilon. (394 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
LATLinker for activation of T cells. (260 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (122 aa)
M3YR72_MUSPFUncharacterized protein. (542 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
IFNGR1Interferon gamma receptor 1. (474 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (647 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
LCKTyrosine-protein kinase. (509 aa)
CD247CD247 molecule. (185 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
NFATC1Nuclear factor of activated T cells 1. (701 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
CD4CD4. (462 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAPK12Mitogen-activated protein kinase. (287 aa)
M3YZX8_MUSPFUncharacterized protein. (144 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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