STRINGSTRING
CNOT8 CNOT8 JAK1 JAK1 STAT3 STAT3 ARPC2 ARPC2 GRIPAP1 GRIPAP1 CRISP1 CRISP1 MELTF MELTF CD4 CD4 IL1B IL1B ACTG1 ACTG1 FBXO11 FBXO11 ACTL8 ACTL8 VCAM1 VCAM1 B2M B2M NPPC NPPC RTF1 RTF1 GADD45B GADD45B CFL1 CFL1 ADIPOQ ADIPOQ MMP27 MMP27 M3WS97_FELCA M3WS97_FELCA TLR2 TLR2 LOC101083959 LOC101083959 IL6 IL6 TLR4 TLR4 EEF1A1 EEF1A1 COX1 COX1 CYTB CYTB ENSFCAP00000027212 ENSFCAP00000027212 PRKAG3 PRKAG3 ENSFCAP00000030280 ENSFCAP00000030280 RPA2 RPA2 ENSFCAP00000032772 ENSFCAP00000032772 LEP LEP SLC26A3-2 SLC26A3-2 ENSFCAP00000034805 ENSFCAP00000034805 ENSFCAP00000036159 ENSFCAP00000036159 RETNLB RETNLB SLC25A2 SLC25A2 ENSFCAP00000043946 ENSFCAP00000043946 ALKAL1 ALKAL1 ENSFCAP00000044386 ENSFCAP00000044386 LOC111558970 LOC111558970 RETN RETN ENSFCAP00000047404 ENSFCAP00000047404 PERM1 PERM1 PPARG PPARG TNF TNF SYCN SYCN RTF2 RTF2 ACAN ACAN EEF1A2 EEF1A2 LSM11 LSM11 LOC109502152 LOC109502152 RINT1 RINT1 SLC25A15 SLC25A15 CD2 CD2 ACTB ACTB CCL19 CCL19
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CNOT8CCR4-NOT transcription complex subunit 8. (292 aa)
JAK1Tyrosine-protein kinase. (1157 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
GRIPAP1GRIP1 associated protein 1. (841 aa)
CRISP1Cysteine rich secretory protein 1; Belongs to the CRISP family. (246 aa)
MELTFMelanotransferrin; Belongs to the transferrin family. (744 aa)
CD4CD4 molecule. (487 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
ACTG1Actin gamma 1. (375 aa)
FBXO11F-box protein 11. (923 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
VCAM1Vascular cell adhesion molecule 1. (748 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (118 aa)
NPPCNatriuretic peptide C. (193 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (234 aa)
CFL1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (166 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (283 aa)
MMP27Matrix metallopeptidase 27. (510 aa)
M3WS97_FELCAArp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (151 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
LOC101083959Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (460 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
EEF1A1Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa)
COX1Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (514 aa)
CYTBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (379 aa)
ENSFCAP00000027212Tr-type G domain-containing protein. (108 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (607 aa)
ENSFCAP00000030280Tr-type G domain-containing protein. (74 aa)
RPA2Replication protein A2. (270 aa)
ENSFCAP00000032772Tr-type G domain-containing protein. (92 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
SLC26A3-2Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
ENSFCAP00000034805Tr-type G domain-containing protein. (119 aa)
ENSFCAP00000036159Tr-type G domain-containing protein. (120 aa)
RETNLBResistin like beta. (110 aa)
SLC25A2Solute carrier family 25 member 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (301 aa)
ENSFCAP00000043946Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (118 aa)
ALKAL1Uncharacterized protein. (283 aa)
ENSFCAP00000044386Uncharacterized protein. (156 aa)
LOC111558970Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
RETNUncharacterized protein. (175 aa)
ENSFCAP00000047404Uncharacterized protein. (56 aa)
PERM1PPARGC1 and ESRR induced regulator, muscle 1. (751 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
SYCNSyncollin. (134 aa)
RTF2Replication termination factor 2. (321 aa)
ACANAggrecan. (2266 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (474 aa)
LSM11LSM11, U7 small nuclear RNA associated. (399 aa)
LOC109502152Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (474 aa)
RINT1RAD50 interactor 1. (794 aa)
SLC25A15Solute carrier family 25 member 15; Belongs to the mitochondrial carrier (TC 2.A.29) family. (331 aa)
CD2CD2 molecule. (376 aa)
ACTBActin beta. (389 aa)
CCL19C-C motif chemokine. (115 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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