73 items (Felis catus) - STRING interaction network

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proteins of unknown 3D structure

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Predicted Interactions

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	CYP11A1	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
	SEH1L	SEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (476 aa)
	ACTL8	Actin like 8; Belongs to the actin family. (366 aa)
	ASB4	Ankyrin repeat and SOCS box containing 4. (426 aa)
	PNMT	Phenylethanolamine N-methyltransferase. (285 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
	NRIP1	Nuclear receptor interacting protein 1. (1155 aa)
	ACTG1	Actin gamma 1. (375 aa)
	PSMG3	Proteasome assembly chaperone 3. (122 aa)
	CYP21A2	Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. (494 aa)
	POMC	Proopiomelanocortin. (258 aa)
	RASSF4	Ras association domain family member 4. (321 aa)
	CYB561	Cytochrome b561. (252 aa)
	APP	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
	CYP17A1	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (508 aa)
	PDZD3	PDZ domain containing 3. (505 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (205 aa)
	DPH5	Diphthamide biosynthesis 5. (279 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
	MRPL17	Mitochondrial ribosomal protein L17; Belongs to the bacterial ribosomal protein bL17 family. (201 aa)
	TMEM127	Transmembrane protein 127. (238 aa)
	HSD3B2	3 beta-hydroxysteroid dehydrogenase; Belongs to the 3-beta-HSD family. (373 aa)
	KCNK17	Potassium channel subfamily K member. (344 aa)
	ARMCX1	Armadillo repeat containing X-linked 1. (458 aa)
	CYB5A	Cytochrome b5 type A; Belongs to the cytochrome b5 family. (134 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (547 aa)
	CNOT1	CCR4-NOT transcription complex subunit 1. (2383 aa)
	MC2R	Melanocortin 2 receptor. (297 aa)
	TSPAN12	Tetraspanin. (314 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (471 aa)
	CLN6	CLN6 transmembrane ER protein. (312 aa)
	FAM13B	Family with sequence similarity 13 member B. (939 aa)
	NDUFA13	NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
	KIF22	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (664 aa)
	SLC7A6OS	Solute carrier family 7 member 6 opposite strand. (377 aa)
	TRERF1	Transcriptional regulating factor 1. (1187 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
	CD1H11orf68	Chromosome D1 C11orf68 homolog. (294 aa)
	ACTB	Actin beta. (389 aa)
	A2M	Alpha-2-macroglobulin. (1511 aa)
	ENSFCAP00000059504	G protein gamma domain-containing protein. (76 aa)
	SEC14L1	SEC14 like lipid binding 1. (720 aa)
	FAM174A	Family with sequence similarity 174 member A. (198 aa)
	CHGB	Chromogranin B. (712 aa)
	ENSFCAP00000057645	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (150 aa)
	ENSFCAP00000057515	Uncharacterized protein. (597 aa)
	BORCS7	Uncharacterized protein. (137 aa)
	PITHD1	PITH domain-containing protein. (318 aa)
	ZNF592	Zinc finger protein 592. (1359 aa)
	TMBIM4	Uncharacterized protein; Belongs to the BI1 family. (254 aa)
	LOC101080976	Uncharacterized protein. (1453 aa)
	MRPL13	Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family. (189 aa)
	PHACTR4	Phosphatase and actin regulator. (752 aa)
	TSPO	Uncharacterized protein. (257 aa)
	ASMTL	Acetylserotonin O-methyltransferase like. (610 aa)
	LOC101097790	Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa)
	NR5A1	Nuclear receptor subfamily 5 group A member 1. (461 aa)
	GNG12	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	LOC101081475	Uncharacterized protein. (1406 aa)
	KHDC4	KH domain containing 4, pre-mRNA splicing factor. (616 aa)
	TOM1L1	Target of myb1 like 1 membrane trafficking protein. (521 aa)
	ADM	Adrenomedullin. (188 aa)
	FEZ2	Fasciculation and elongation protein zeta 2. (383 aa)
	CYB5R1	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
	NR5A2	Nuclear receptor subfamily 5 group A member 2. (541 aa)
	TOMM7	Translocase of outer mitochondrial membrane 7. (55 aa)
	PAN3	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (1092 aa)
	RXYLT1	Ribitol xylosyltransferase 1. (443 aa)
	TMEM167B	Protein kish; Involved in the early part of the secretory pathway. (74 aa)
	NAT9	N-acetyltransferase domain-containing protein. (413 aa)
	LOC101083640	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (150 aa)
	TMEM132E	Transmembrane protein 132E. (1074 aa)
	GAL	Galanin and GMAP prepropeptide. (249 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A2M	APP	ENSFCAP00000060291	ENSFCAP00000001445	Alpha-2-macroglobulin.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.513
A2M	CYB561	ENSFCAP00000060291	ENSFCAP00000001919	Alpha-2-macroglobulin.	Cytochrome b561.	0.408
ADM	AGT	ENSFCAP00000043827	ENSFCAP00000022349	Adrenomedullin.	Angiotensinogen; Belongs to the serpin family.	0.754
AGT	ADM	ENSFCAP00000022349	ENSFCAP00000043827	Angiotensinogen; Belongs to the serpin family.	Adrenomedullin.	0.754
AGT	APP	ENSFCAP00000022349	ENSFCAP00000001445	Angiotensinogen; Belongs to the serpin family.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.424
AGT	GAL	ENSFCAP00000022349	ENSFCAP00000032454	Angiotensinogen; Belongs to the serpin family.	Galanin and GMAP prepropeptide.	0.597
AGT	POMC	ENSFCAP00000022349	ENSFCAP00000003372	Angiotensinogen; Belongs to the serpin family.	Proopiomelanocortin.	0.778
APP	A2M	ENSFCAP00000001445	ENSFCAP00000060291	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Alpha-2-macroglobulin.	0.513
APP	AGT	ENSFCAP00000001445	ENSFCAP00000022349	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Angiotensinogen; Belongs to the serpin family.	0.424
APP	SCARB1	ENSFCAP00000001445	ENSFCAP00000031639	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.403
CYB561	A2M	ENSFCAP00000001919	ENSFCAP00000060291	Cytochrome b561.	Alpha-2-macroglobulin.	0.408
CYB5A	CYB5R1	ENSFCAP00000023331	ENSFCAP00000041154	Cytochrome b5 type A; Belongs to the cytochrome b5 family.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.910
CYB5A	CYP17A1	ENSFCAP00000023331	ENSFCAP00000001165	Cytochrome b5 type A; Belongs to the cytochrome b5 family.	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	0.833
CYB5A	CYP21A2	ENSFCAP00000023331	ENSFCAP00000004176	Cytochrome b5 type A; Belongs to the cytochrome b5 family.	Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.	0.523
CYB5A	HSD3B2	ENSFCAP00000023331	ENSFCAP00000024982	Cytochrome b5 type A; Belongs to the cytochrome b5 family.	3 beta-hydroxysteroid dehydrogenase; Belongs to the 3-beta-HSD family.	0.430
CYB5R1	CYB5A	ENSFCAP00000041154	ENSFCAP00000023331	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Cytochrome b5 type A; Belongs to the cytochrome b5 family.	0.910
CYB5R1	ENSFCAP00000057645	ENSFCAP00000041154	ENSFCAP00000057645	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.704
CYB5R1	LOC101083640	ENSFCAP00000041154	ENSFCAP00000033839	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.878
CYP11A1	CYP17A1	ENSFCAP00000010102	ENSFCAP00000001165	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	0.956
CYP11A1	CYP21A2	ENSFCAP00000010102	ENSFCAP00000004176	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.	0.948