47 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHLD2	Shieldin complex subunit 2. (1045 aa)
	SOX11	Transcription factor SOX. (412 aa)
	PIK3IP1	Phosphoinositide-3-kinase interacting protein 1. (311 aa)
	GH1	Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (246 aa)
	SDC1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
	ITGA11	Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1189 aa)
	MAPRE1	Microtubule associated protein RP/EB family member 1. (268 aa)
	PLD2	Phospholipase. (984 aa)
	KLRAP1	Uncharacterized protein. (273 aa)
	SLAIN2	SLAIN motif family member 2. (608 aa)
	CENPI	Centromere protein I. (791 aa)
	NIFK	Nucleolar protein interacting with the FHA domain of MKI67. (292 aa)
	CHAC1	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (222 aa)
	EML4	EMAP like 4. (1006 aa)
	NCKIPSD	NCK interacting protein with SH3 domain. (721 aa)
	IKZF3	IKAROS family zinc finger 3. (509 aa)
	NPM1	Nucleophosmin 1. (294 aa)
	ENTHD1	ENTH domain containing 1. (611 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
	CENPK	Centromere protein K. (292 aa)
	SLX4IP	SLX4 interacting protein. (406 aa)
	DOCK10	Dedicator of cytokinesis 10; Belongs to the DOCK family. (2220 aa)
	YBEY	Uncharacterized protein. (345 aa)
	MAPRE3	Microtubule associated protein RP/EB family member 3. (281 aa)
	TNFRSF8	TNF receptor superfamily member 8. (593 aa)
	TOM1	Target of myb1 membrane trafficking protein; Belongs to the TOM1 family. (510 aa)
	OSM	Oncostatin M. (238 aa)
	DCTN1	CAP-Gly domain-containing protein. (1279 aa)
	PLD1	Phospholipase. (1074 aa)
	REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit. (3131 aa)
	HELQ	Helicase, POLQ like. (1063 aa)
	DOCK11	Dedicator of cytokinesis 11; Belongs to the DOCK family. (2078 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
	CD22	CD22 molecule. (845 aa)
	IZUMO4	IZUMO family member 4. (229 aa)
	CLASRP	CLK4 associating serine/arginine rich protein. (678 aa)
	CLIP1	CAP-Gly domain containing linker protein 1. (1438 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
	DOCK9	Dedicator of cytokinesis 9; Belongs to the DOCK family. (2132 aa)
	HBM	Hemoglobin subunit mu; Belongs to the globin family. (141 aa)
	CADM1	Cell adhesion molecule 1. (593 aa)
	CLASP1	Cytoplasmic linker associated protein 1. (1597 aa)
	TPPP	Tubulin polymerization promoting protein. (295 aa)
	COG2	Component of oligomeric golgi complex 2. (761 aa)
	TSPEAR	Thrombospondin type laminin G domain and EAR repeats. (678 aa)
	LOC101097290	GLOBIN domain-containing protein; Belongs to the globin family. (189 aa)
	ENSFCAP00000060460	Ly49 domain-containing protein. (157 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD22	SDC1	ENSFCAP00000046244	ENSFCAP00000004966	CD22 molecule.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.462
CD22	TNF	ENSFCAP00000046244	ENSFCAP00000051032	CD22 molecule.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.527
CENPI	CENPK	ENSFCAP00000009626	ENSFCAP00000024264	Centromere protein I.	Centromere protein K.	0.997
CENPI	EML4	ENSFCAP00000009626	ENSFCAP00000014259	Centromere protein I.	EMAP like 4.	0.578
CENPI	MAPRE1	ENSFCAP00000009626	ENSFCAP00000007206	Centromere protein I.	Microtubule associated protein RP/EB family member 1.	0.454
CENPI	MAPRE3	ENSFCAP00000009626	ENSFCAP00000031692	Centromere protein I.	Microtubule associated protein RP/EB family member 3.	0.454
CENPI	NIFK	ENSFCAP00000009626	ENSFCAP00000010022	Centromere protein I.	Nucleolar protein interacting with the FHA domain of MKI67.	0.580
CENPI	NPM1	ENSFCAP00000009626	ENSFCAP00000022124	Centromere protein I.	Nucleophosmin 1.	0.633
CENPK	CENPI	ENSFCAP00000024264	ENSFCAP00000009626	Centromere protein K.	Centromere protein I.	0.997
CENPK	EML4	ENSFCAP00000024264	ENSFCAP00000014259	Centromere protein K.	EMAP like 4.	0.524
CENPK	NPM1	ENSFCAP00000024264	ENSFCAP00000022124	Centromere protein K.	Nucleophosmin 1.	0.599
CLASP1	CLASRP	ENSFCAP00000052865	ENSFCAP00000048926	Cytoplasmic linker associated protein 1.	CLK4 associating serine/arginine rich protein.	0.420
CLASP1	CLIP1	ENSFCAP00000052865	ENSFCAP00000050098	Cytoplasmic linker associated protein 1.	CAP-Gly domain containing linker protein 1.	0.698
CLASP1	MAPRE1	ENSFCAP00000052865	ENSFCAP00000007206	Cytoplasmic linker associated protein 1.	Microtubule associated protein RP/EB family member 1.	0.646
CLASP1	SLAIN2	ENSFCAP00000052865	ENSFCAP00000008547	Cytoplasmic linker associated protein 1.	SLAIN motif family member 2.	0.487
CLASRP	CLASP1	ENSFCAP00000048926	ENSFCAP00000052865	CLK4 associating serine/arginine rich protein.	Cytoplasmic linker associated protein 1.	0.420
CLASRP	CLIP1	ENSFCAP00000048926	ENSFCAP00000050098	CLK4 associating serine/arginine rich protein.	CAP-Gly domain containing linker protein 1.	0.441
CLIP1	CLASP1	ENSFCAP00000050098	ENSFCAP00000052865	CAP-Gly domain containing linker protein 1.	Cytoplasmic linker associated protein 1.	0.698
CLIP1	CLASRP	ENSFCAP00000050098	ENSFCAP00000048926	CAP-Gly domain containing linker protein 1.	CLK4 associating serine/arginine rich protein.	0.441
CLIP1	DCTN1	ENSFCAP00000050098	ENSFCAP00000036915	CAP-Gly domain containing linker protein 1.	CAP-Gly domain-containing protein.	0.928