STRINGSTRING
NDUFA13 NDUFA13 NUPR1 NUPR1 TP73 TP73 CACYBP CACYBP GREB1 GREB1 RRM1 RRM1 REV1 REV1 PRMT5 PRMT5 CENPF CENPF RELA RELA LMO4 LMO4 TP53 TP53 STC2 STC2 NDUFA4 NDUFA4 ZMYND8 ZMYND8 LRRC28 LRRC28 HMMR HMMR DYRK3 DYRK3 ETV5 ETV5 CLDN8 CLDN8 ESR1 ESR1 ING2 ING2 CTSO CTSO GEMIN2 GEMIN2 KPNA4 KPNA4 METTL17 METTL17 NSUN5 NSUN5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (749 aa)
CACYBPCalcyclin binding protein. (230 aa)
GREB1Growth regulating estrogen receptor binding 1. (1943 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1273 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (652 aa)
CENPFCentromere protein F. (3094 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
LMO4LIM domain only 4. (165 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
STC2Stanniocalcin 2. (302 aa)
NDUFA4Uncharacterized protein. (82 aa)
ZMYND8Zinc finger MYND-type containing 8. (1224 aa)
LRRC28Leucine rich repeat containing 28. (367 aa)
HMMRHyaluronan mediated motility receptor. (714 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa)
ETV5ETS variant 5. (608 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (227 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
ING2Inhibitor of growth protein. (280 aa)
CTSOCathepsin O; Belongs to the peptidase C1 family. (319 aa)
GEMIN2Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family. (279 aa)
KPNA4Importin subunit alpha; Functions in nuclear protein import. (521 aa)
METTL17Methyltransferase like 17. (464 aa)
NSUN5NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (542 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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