STRINGSTRING
TSLP TSLP S100A5 S100A5 CDH5-2 CDH5-2 TFF3 TFF3 OR10K2 OR10K2 CNGA2 CNGA2 LOC101099928 LOC101099928 OR10K1 OR10K1 IL6 IL6 CNGA4 CNGA4 LOC101088359 LOC101088359 M3XBT1_FELCA M3XBT1_FELCA LOC101101212 LOC101101212 CLTRN CLTRN GADD45A GADD45A CPSF4 CPSF4 CFTR CFTR CDH5 CDH5 ACE2 ACE2 MUC19 MUC19 MUC5AC MUC5AC NEUROG1 NEUROG1 MUC2 MUC2 TMPRSS2 TMPRSS2 ENSFCAP00000058025 ENSFCAP00000058025 AKAP14 AKAP14 PTRHD1 PTRHD1 ADCY3 ADCY3 CPSF4L CPSF4L IL1B IL1B OCLN OCLN LGR5 LGR5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TSLPThymic stromal lymphopoietin. (224 aa)
S100A5Protein S100; Belongs to the S-100 family. (108 aa)
CDH5-2Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (314 aa)
TFF3Trefoil factor 3; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity). (80 aa)
OR10K2Olfactory receptor family 10 subfamily K member 2. (314 aa)
CNGA2Cyclic nucleotide gated channel subunit alpha 2. (667 aa)
LOC101099928G_PROTEIN_RECEP_F1_2 domain-containing protein. (309 aa)
OR10K1Olfactory receptor family 10 subfamily K member 1. (313 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
CNGA4Cyclic nucleotide gated channel subunit alpha 4. (575 aa)
LOC101088359G_PROTEIN_RECEP_F1_2 domain-containing protein. (329 aa)
M3XBT1_FELCAG_PROTEIN_RECEP_F1_2 domain-containing protein. (326 aa)
LOC101101212Uncharacterized protein. (67 aa)
CLTRNCollectrin domain-containing protein. (222 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha; Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). (165 aa)
CPSF4Cleavage and polyadenylation specific factor 4. (269 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
CDH5Uncharacterized protein. (402 aa)
ACE2Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...] (805 aa)
MUC19Uncharacterized protein. (1256 aa)
MUC5ACUncharacterized protein. (3235 aa)
NEUROG1Neurogenin 1. (243 aa)
MUC2Uncharacterized protein. (921 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)
ENSFCAP00000058025Uncharacterized protein. (91 aa)
AKAP14Uncharacterized protein. (132 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
CPSF4LCleavage and polyadenylation specific factor 4 like. (216 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (521 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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