STRINGSTRING
HMOX1 HMOX1 C1QB C1QB LOC101100279 LOC101100279 CCL2 CCL2 LOC101080762 LOC101080762 CCL5 CCL5 DDX58 DDX58 APP APP JAK1 JAK1 STAT3 STAT3 IL4 IL4 SPI1 SPI1 CX3CR1 CX3CR1 CD163 CD163 CYBB CYBB HIF1A HIF1A CSF1R CSF1R IDO1 IDO1 CD4 CD4 TGFB1 TGFB1 GFAP GFAP TNFSF11 TNFSF11 CASP4 CASP4 ACTG1 ACTG1 SIGLEC1 SIGLEC1 TM4SF19 TM4SF19 IL1A IL1A FCAR FCAR DCSTAMP DCSTAMP IFNG IFNG ACTL8 ACTL8 VCAM1 VCAM1 B2M B2M CD207 CD207 IL10 IL10 IL2 IL2 MMP9 MMP9 FUOM FUOM TLR8 TLR8 TLR2 TLR2 M3X1V3_FELCA M3X1V3_FELCA IL6 IL6 TLR4 TLR4 XK XK TLR3 TLR3 CD36 CD36 CUZD1 CUZD1 RPA2 RPA2 CASP3 CASP3 SLC26A3-2 SLC26A3-2 OPALIN OPALIN NHP2 NHP2 ISG15 ISG15 MYD88 MYD88 ITGB2 ITGB2 TLR7 TLR7 MARCKS MARCKS LOC111559157 LOC111559157 LGALS3 LGALS3 CLEC4F CLEC4F SELL SELL IGF1 IGF1 CXCL10 CXCL10 LOC111558970 LOC111558970 SOST SOST SPP1 SPP1 SCARF1 SCARF1 ACOD1 ACOD1 RUNX2 RUNX2 STAT1 STAT1 PPARG PPARG TNF TNF CTSB CTSB MRC1 MRC1 CTSK CTSK BGLAP BGLAP TYROBP TYROBP ENSFCAP00000053572 ENSFCAP00000053572 CD68 CD68 IL1B IL1B NFATC1 NFATC1 B4GALT5 B4GALT5 ARG1 ARG1 PTPRC PTPRC CD47 CD47 MX1 MX1 CD86 CD86 ACTB ACTB LOC105260178 LOC105260178
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HMOX1Heme oxygenase 1. (404 aa)
C1QBComplement C1q B chain. (254 aa)
LOC101100279Ig-like domain-containing protein. (413 aa)
CCL2C-C motif chemokine. (99 aa)
LOC101080762Ig-like domain-containing protein. (331 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
DDX58DExD/H-box helicase 58. (929 aa)
APPAmyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
JAK1Tyrosine-protein kinase. (1157 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa)
CD163CD163 molecule. (1102 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...] (1213 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (407 aa)
CD4CD4 molecule. (487 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (472 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
CASP4Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (495 aa)
ACTG1Actin gamma 1. (375 aa)
SIGLEC1Sialic acid binding Ig like lectin 1. (1720 aa)
TM4SF19Uncharacterized protein. (209 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
FCARIg domain-containing protein. (176 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
VCAM1Vascular cell adhesion molecule 1. (748 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (118 aa)
CD207CD207 molecule. (329 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
MMP9Matrix metallopeptidase 9. (705 aa)
FUOMFucose mutarotase. (154 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
M3X1V3_FELCAIg-like domain-containing protein. (313 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
XKXK-related protein. (444 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
CUZD1Uncharacterized protein. (978 aa)
RPA2Replication protein A2. (270 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
SLC26A3-2Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
OPALINOligodendrocytic myelin paranodal and inner loop protein. (142 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (167 aa)
ISG15ISG15 ubiquitin like modifier. (157 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
ITGB2Integrin beta. (867 aa)
TLR7TIR domain-containing protein; Belongs to the Toll-like receptor family. (1071 aa)
MARCKSMyristoylated alanine rich protein kinase C substrate. (353 aa)
LOC111559157Ig-like domain-containing protein. (280 aa)
LGALS3Galectin. (278 aa)
CLEC4FC-type lectin domain family 4 member F. (609 aa)
SELLSelectin L. (394 aa)
IGF1Insulin like growth factor 1. (195 aa)
CXCL10C-X-C motif chemokine. (98 aa)
LOC111558970Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
SOSTSclerostin. (212 aa)
SPP1Secreted phosphoprotein 1. (299 aa)
SCARF1Scavenger receptor class F member 1. (830 aa)
ACOD1Aconitate decarboxylase 1. (482 aa)
RUNX2RUNX family transcription factor 2. (584 aa)
STAT1Signal transducer and activator of transcription. (885 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
MRC1Mannose receptor C-type 1. (1484 aa)
CTSKCathepsin S; Belongs to the peptidase C1 family. (445 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (102 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (137 aa)
ENSFCAP00000053572Uncharacterized protein. (1072 aa)
CD68Uncharacterized protein. (473 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
NFATC1Nuclear factor of activated T cells 1. (1085 aa)
B4GALT5Beta-1,4-galactosyltransferase 5. (464 aa)
ARG1Arginase. (329 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
CD47CD47 molecule. (326 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (675 aa)
CD86B-lymphocyte activation antigen B7-2 (CD86). (332 aa)
ACTBActin beta. (389 aa)
LOC105260178Ig-like domain-containing protein. (357 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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