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HMOX1 | Heme oxygenase 1. (404 aa) | ||||
C1QB | Complement C1q B chain. (254 aa) | ||||
LOC101100279 | Ig-like domain-containing protein. (413 aa) | ||||
CCL2 | C-C motif chemokine. (99 aa) | ||||
LOC101080762 | Ig-like domain-containing protein. (331 aa) | ||||
CCL5 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa) | ||||
DDX58 | DExD/H-box helicase 58. (929 aa) | ||||
APP | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa) | ||||
JAK1 | Tyrosine-protein kinase. (1157 aa) | ||||
STAT3 | Signal transducer and activator of transcription. (770 aa) | ||||
IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa) | ||||
SPI1 | Spi-1 proto-oncogene. (270 aa) | ||||
CX3CR1 | C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa) | ||||
CD163 | CD163 molecule. (1102 aa) | ||||
CYBB | Cytochrome b-245 beta chain. (570 aa) | ||||
HIF1A | Hypoxia inducible factor 1 subunit alpha. (825 aa) | ||||
CSF1R | Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...] (1213 aa) | ||||
IDO1 | Indoleamine 2,3-dioxygenase 1. (407 aa) | ||||
CD4 | CD4 molecule. (487 aa) | ||||
TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) | ||||
GFAP | Glial fibrillary acidic protein; Belongs to the intermediate filament family. (472 aa) | ||||
TNFSF11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa) | ||||
CASP4 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (495 aa) | ||||
ACTG1 | Actin gamma 1. (375 aa) | ||||
SIGLEC1 | Sialic acid binding Ig like lectin 1. (1720 aa) | ||||
TM4SF19 | Uncharacterized protein. (209 aa) | ||||
IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa) | ||||
FCAR | Ig domain-containing protein. (176 aa) | ||||
DCSTAMP | Dendrocyte expressed seven transmembrane protein. (470 aa) | ||||
IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa) | ||||
ACTL8 | Actin like 8; Belongs to the actin family. (366 aa) | ||||
VCAM1 | Vascular cell adhesion molecule 1. (748 aa) | ||||
B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (118 aa) | ||||
CD207 | CD207 molecule. (329 aa) | ||||
IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) | ||||
IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa) | ||||
MMP9 | Matrix metallopeptidase 9. (705 aa) | ||||
FUOM | Fucose mutarotase. (154 aa) | ||||
TLR8 | Toll-like receptor 8; Belongs to the Toll-like receptor family. (1039 aa) | ||||
TLR2 | Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa) | ||||
M3X1V3_FELCA | Ig-like domain-containing protein. (313 aa) | ||||
IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa) | ||||
TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa) | ||||
XK | XK-related protein. (444 aa) | ||||
TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa) | ||||
CD36 | CD36 molecule; Belongs to the CD36 family. (472 aa) | ||||
CUZD1 | Uncharacterized protein. (978 aa) | ||||
RPA2 | Replication protein A2. (270 aa) | ||||
CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa) | ||||
SLC26A3-2 | Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa) | ||||
OPALIN | Oligodendrocytic myelin paranodal and inner loop protein. (142 aa) | ||||
NHP2 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (167 aa) | ||||
ISG15 | ISG15 ubiquitin like modifier. (157 aa) | ||||
MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa) | ||||
ITGB2 | Integrin beta. (867 aa) | ||||
TLR7 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (1071 aa) | ||||
MARCKS | Myristoylated alanine rich protein kinase C substrate. (353 aa) | ||||
LOC111559157 | Ig-like domain-containing protein. (280 aa) | ||||
LGALS3 | Galectin. (278 aa) | ||||
CLEC4F | C-type lectin domain family 4 member F. (609 aa) | ||||
SELL | Selectin L. (394 aa) | ||||
IGF1 | Insulin like growth factor 1. (195 aa) | ||||
CXCL10 | C-X-C motif chemokine. (98 aa) | ||||
LOC111558970 | Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa) | ||||
SOST | Sclerostin. (212 aa) | ||||
SPP1 | Secreted phosphoprotein 1. (299 aa) | ||||
SCARF1 | Scavenger receptor class F member 1. (830 aa) | ||||
ACOD1 | Aconitate decarboxylase 1. (482 aa) | ||||
RUNX2 | RUNX family transcription factor 2. (584 aa) | ||||
STAT1 | Signal transducer and activator of transcription. (885 aa) | ||||
PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa) | ||||
TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) | ||||
CTSB | Cathepsin B; Belongs to the peptidase C1 family. (339 aa) | ||||
MRC1 | Mannose receptor C-type 1. (1484 aa) | ||||
CTSK | Cathepsin S; Belongs to the peptidase C1 family. (445 aa) | ||||
BGLAP | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (102 aa) | ||||
TYROBP | TYRO protein tyrosine kinase binding protein. (137 aa) | ||||
ENSFCAP00000053572 | Uncharacterized protein. (1072 aa) | ||||
CD68 | Uncharacterized protein. (473 aa) | ||||
IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) | ||||
NFATC1 | Nuclear factor of activated T cells 1. (1085 aa) | ||||
B4GALT5 | Beta-1,4-galactosyltransferase 5. (464 aa) | ||||
ARG1 | Arginase. (329 aa) | ||||
PTPRC | Protein tyrosine phosphatase receptor type C. (1299 aa) | ||||
CD47 | CD47 molecule. (326 aa) | ||||
MX1 | MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (675 aa) | ||||
CD86 | B-lymphocyte activation antigen B7-2 (CD86). (332 aa) | ||||
ACTB | Actin beta. (389 aa) | ||||
LOC105260178 | Ig-like domain-containing protein. (357 aa) |