STRINGSTRING
KLRK1 KLRK1 KCNG3 KCNG3 CD244 CD244 GZMA GZMA FAM214A FAM214A PRF1 PRF1 IL6 IL6 CD226 CD226 FAM92A FAM92A IL2 IL2 IL10 IL10 NCR2 NCR2 IFNG IFNG NRIP1 NRIP1 CD4 CD4 RNF19B RNF19B IL23R IL23R PDZD3 PDZD3 FCGR3A FCGR3A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLRK1Killer cell lectin like receptor K1. (215 aa)
KCNG3Cytochrome c oxidase subunit 7A2 like; Belongs to the potassium channel family. (487 aa)
CD244CD244 molecule. (377 aa)
GZMAGranzyme A; Belongs to the peptidase S1 family. (271 aa)
FAM214AFamily with sequence similarity 214 member A. (1096 aa)
PRF1Perforin 1. (555 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
CD226CD226 molecule. (332 aa)
FAM92AFamily with sequence similarity 92 member A. (291 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
NCR2Ig-like domain-containing protein. (248 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
CD4CD4 molecule. (487 aa)
RNF19BRBR-type E3 ubiquitin transferase. (734 aa)
IL23RInterleukin 23 receptor. (631 aa)
PDZD3PDZ domain containing 3. (505 aa)
FCGR3ACD16. (250 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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