STRINGSTRING
EFNB2 EFNB2 PDSS1 PDSS1 THBD THBD VCAM1 VCAM1 TNS4 TNS4 ICAM1 ICAM1 FN1 FN1 VEGFC VEGFC PDPN PDPN STAB2 STAB2 IL1B IL1B ITGA10 ITGA10 ERN1 ERN1 GOLGA3 GOLGA3 ZRANB1 ZRANB1 FLT4 FLT4 CLEC4G CLEC4G LYVE1 LYVE1 BMPR2 BMPR2 EDN1 EDN1 RIPK2 RIPK2 LAMC1 LAMC1 CLDN5 CLDN5 RXFP1 RXFP1 CSDE1 CSDE1 M3X1N0_FELCA M3X1N0_FELCA IL6 IL6 M3X975_FELCA M3X975_FELCA SCD5 SCD5 DGKE DGKE AFM AFM CSGALNACT2 CSGALNACT2 TJP1 TJP1 HHIP HHIP SKIL SKIL EPHB4 EPHB4 SELE SELE FAM124B FAM124B VWF VWF ARNTL2 ARNTL2 FADD FADD ASGR1 ASGR1 VEGFA VEGFA P4HA3 P4HA3 ATF7 ATF7 PECAM1 PECAM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EFNB2Ephrin B2; Belongs to the ephrin family. (333 aa)
PDSS1Decaprenyl diphosphate synthase subunit 1; Belongs to the FPP/GGPP synthase family. (408 aa)
THBDThrombomodulin. (672 aa)
VCAM1Vascular cell adhesion molecule 1. (748 aa)
TNS4Tensin 4. (715 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
FN1Fibronectin 1. (2475 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
PDPNPodoplanin. (163 aa)
STAB2Stabilin 2. (2551 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1165 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (972 aa)
GOLGA3Golgin A3. (1489 aa)
ZRANB1Zinc finger RANBP2-type containing 1. (761 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1405 aa)
CLEC4GC-type lectin domain family 4 member G. (317 aa)
LYVE1Lymphatic vessel endothelial hyaluronan receptor 1. (323 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
RXFP1Relaxin family peptide receptor 1. (785 aa)
CSDE1Cold shock domain containing E1. (844 aa)
M3X1N0_FELCAUncharacterized protein. (276 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
M3X975_FELCAUncharacterized protein. (543 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (330 aa)
DGKEDiacylglycerol kinase. (564 aa)
AFMAfamin. (601 aa)
CSGALNACT2Hexosyltransferase. (542 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (2008 aa)
HHIPHedgehog interacting protein. (682 aa)
SKILSKI like proto-oncogene. (686 aa)
EPHB4EPH receptor B4. (987 aa)
SELESelectin E. (638 aa)
FAM124BFamily with sequence similarity 124 member B. (460 aa)
VWFUncharacterized protein. (2818 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (634 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
ASGR1Asialoglycoprotein receptor 1. (339 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (450 aa)
P4HA3Prolyl 4-hydroxylase subunit alpha 3. (544 aa)
ATF7Uncharacterized protein. (511 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (764 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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