60 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPTAN1	Spectrin alpha, non-erythrocytic 1. (2725 aa)
	HADH	Hydroxyacyl-CoA dehydrogenase. (338 aa)
	TF	Transferrin; Belongs to the transferrin family. (706 aa)
	ENSFCAP00000060491	Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (308 aa)
	ANXA6	Annexin. (723 aa)
	LOC111558717	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (317 aa)
	RYR2	Ryanodine receptor 2. (4967 aa)
	ENSFCAP00000053301	Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (133 aa)
	VIM	Vimentin; Belongs to the intermediate filament family. (466 aa)
	OGDH	Oxoglutarate dehydrogenase. (1038 aa)
	ENSFCAP00000048834	Uncharacterized protein. (139 aa)
	MYBPC3	Myosin binding protein C, cardiac. (1273 aa)
	MDH2	Malate dehydrogenase, mitochondrial; Belongs to the LDH/MDH superfamily. MDH type 1 family. (338 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	ENSFCAP00000029907	Phosphoglycerate kinase. (246 aa)
	MYL7	Myosin light chain 7. (216 aa)
	CKM	Creatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family. (424 aa)
	SLC25A6	Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (318 aa)
	DES	Desmin; Belongs to the intermediate filament family. (514 aa)
	SHOX2	Uncharacterized protein. (321 aa)
	TBX15	T-box transcription factor 15. (602 aa)
	MB	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
	SHOX	Short stature homeobox. (320 aa)
	TBX18	T-box transcription factor 18. (775 aa)
	ENSFCAP00000040280	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (127 aa)
	ENSFCAP00000039745	Uncharacterized protein. (55 aa)
	HSPA8	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (667 aa)
	LOC101098213	Cytochrome c. (105 aa)
	SLC25A4	Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
	ENSFCAP00000033387	Uncharacterized protein. (491 aa)
	NECAB1	N-terminal EF-hand calcium binding protein 1. (429 aa)
	NNT	Nicotinamide nucleotide transhydrogenase. (1088 aa)
	NECAB3	N-terminal EF-hand calcium binding protein 3. (371 aa)
	HCN4	Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1202 aa)
	KCNK7	Potassium two pore domain channel subfamily K member 7; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (307 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
	SLC25A5	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
	MYH6	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
	ATP5F1B	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
	PYGM	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
	PGK1	Phosphoglycerate kinase. (454 aa)
	ALDOA	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (469 aa)
	ACO2	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (781 aa)
	HCN2	Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (895 aa)
	ATP5PO	Uncharacterized protein. (213 aa)
	HSPD1	Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa)
	ATP5F1A	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (451 aa)
	PGK2	Phosphoglycerate kinase. (417 aa)
	M3X4Q0_FELCA	Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (215 aa)
	LOC101100947	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	HCN1	Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (882 aa)
	VCL	Vinculin. (1066 aa)
	M3XE36_FELCA	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (243 aa)
	ENSFCAP00000025816	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (145 aa)
	GJC1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
	ENSFCAP00000027328	Cytochrome c domain-containing protein; Belongs to the cytochrome c family. (103 aa)
	ENSFCAP00000027525	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	LDB3	LIM domain binding 3. (723 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (618 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACO2	ALDOA	ENSFCAP00000015908	ENSFCAP00000013145	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.600
ACO2	ATP5F1A	ENSFCAP00000015908	ENSFCAP00000019700	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.722
ACO2	ATP5F1B	ENSFCAP00000015908	ENSFCAP00000011162	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.644
ACO2	ATP5PO	ENSFCAP00000015908	ENSFCAP00000017480	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Uncharacterized protein.	0.422
ACO2	ENSFCAP00000025816	ENSFCAP00000015908	ENSFCAP00000025816	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	0.436
ACO2	ENSFCAP00000027328	ENSFCAP00000015908	ENSFCAP00000027328	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Cytochrome c domain-containing protein; Belongs to the cytochrome c family.	0.437
ACO2	ENSFCAP00000027525	ENSFCAP00000015908	ENSFCAP00000027525	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.437
ACO2	ENSFCAP00000039745	ENSFCAP00000015908	ENSFCAP00000039745	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Uncharacterized protein.	0.436
ACO2	ENSFCAP00000040280	ENSFCAP00000015908	ENSFCAP00000040280	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	0.436
ACO2	HSPD1	ENSFCAP00000015908	ENSFCAP00000019234	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family.	0.436
ACO2	IDH2	ENSFCAP00000015908	ENSFCAP00000020172	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.993
ACO2	LOC101098213	ENSFCAP00000015908	ENSFCAP00000036284	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Cytochrome c.	0.437
ACO2	LOC101100947	ENSFCAP00000015908	ENSFCAP00000022576	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.437
ACO2	MDH2	ENSFCAP00000015908	ENSFCAP00000000558	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Malate dehydrogenase, mitochondrial; Belongs to the LDH/MDH superfamily. MDH type 1 family.	0.806
ACO2	OGDH	ENSFCAP00000015908	ENSFCAP00000048889	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Oxoglutarate dehydrogenase.	0.901
ACO2	PGK2	ENSFCAP00000015908	ENSFCAP00000020358	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Phosphoglycerate kinase.	0.435
ALB	ANXA6	ENSFCAP00000028536	ENSFCAP00000056723	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Annexin.	0.489
ALB	ENSFCAP00000027328	ENSFCAP00000028536	ENSFCAP00000027328	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Cytochrome c domain-containing protein; Belongs to the cytochrome c family.	0.437
ALB	ENSFCAP00000027525	ENSFCAP00000028536	ENSFCAP00000027525	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.437
ALB	ENSFCAP00000033387	ENSFCAP00000028536	ENSFCAP00000033387	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Uncharacterized protein.	0.441