STRINGSTRING
JAML JAML LRRC25 LRRC25 CD80 CD80 IFNG IFNG MTIF3 MTIF3 MS4A7 MS4A7 DSTYK DSTYK IL1B IL1B CD4 CD4 CSF2 CSF2 SPATA2L SPATA2L IL4 IL4 C1RL C1RL CD83 CD83 TMEM107 TMEM107 TMEM60 TMEM60 ENSFCAP00000033605 ENSFCAP00000033605 SDHAF3 SDHAF3 IRF7 IRF7 GLMP GLMP DHX36 DHX36 HMCES HMCES NSL1 NSL1 SPINK8 SPINK8 ENSFCAP00000049005 ENSFCAP00000049005 IER5 IER5 TMEM18 TMEM18 RSL24D1 RSL24D1 NRBF2 NRBF2 ENSFCAP00000056878 ENSFCAP00000056878 ENSFCAP00000058266 ENSFCAP00000058266 CLEC7A CLEC7A UBTD2 UBTD2 CD86 CD86 ZDHHC4 ZDHHC4 LOC102902084 LOC102902084 TLR3 TLR3 JAG2 JAG2 MYNN MYNN TLR4 TLR4 IL6 IL6 LOC101081599 LOC101081599 LOC101100669 LOC101100669 FUNDC2 FUNDC2 CD40 CD40 IL10 IL10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAMLUncharacterized protein. (403 aa)
LRRC25Leucine rich repeat containing 25. (307 aa)
CD80B-lymphocyte activation antigen B7-1 (CD80). (292 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
MTIF3Mitochondrial translational initiation factor 3. (298 aa)
MS4A7Membrane spanning 4-domains A7. (280 aa)
DSTYKDual serine/threonine and tyrosine protein kinase. (929 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
CD4CD4 molecule. (487 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (142 aa)
SPATA2LSpermatogenesis associated 2 like. (414 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
C1RLPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (278 aa)
CD83CD83 molecule. (391 aa)
TMEM107Transmembrane protein 107. (140 aa)
TMEM60Transmembrane protein 60. (133 aa)
ENSFCAP00000033605Uncharacterized protein. (147 aa)
SDHAF3Succinate dehydrogenase complex assembly factor 3. (125 aa)
IRF7Interferon regulatory factor 7. (512 aa)
GLMPGlycosylated lysosomal membrane protein. (488 aa)
DHX36DEAH-box helicase 36. (1012 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (351 aa)
NSL1NSL1 component of MIS12 kinetochore complex. (360 aa)
SPINK8Serine peptidase inhibitor, Kazal type 8 (putative). (93 aa)
ENSFCAP00000049005CUB domain-containing protein. (172 aa)
IER5Immediate early response 5. (319 aa)
TMEM18Transmembrane protein 18. (154 aa)
RSL24D1Ribosomal L24 domain containing 1. (178 aa)
NRBF2Nuclear receptor binding factor 2. (288 aa)
ENSFCAP00000056878Uncharacterized protein. (63 aa)
ENSFCAP00000058266CUB domain-containing protein. (233 aa)
CLEC7AC-type lectin domain containing 7A. (250 aa)
UBTD2Ubiquitin domain containing 2. (251 aa)
CD86B-lymphocyte activation antigen B7-2 (CD86). (332 aa)
ZDHHC4Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (375 aa)
LOC102902084Uncharacterized protein. (211 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1609 aa)
MYNNMyoneurin. (610 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
LOC101081599SCY domain-containing protein. (158 aa)
LOC101100669Uncharacterized protein. (186 aa)
FUNDC2FUN14 domain containing 2. (190 aa)
CD40CD40 molecule. (324 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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