STRINGSTRING
DOCK2 DOCK2 MYO9B MYO9B RHOF RHOF ARHGAP10 ARHGAP10 NCK2 NCK2 TIAM1 TIAM1 ARPC2 ARPC2 DOCK3 DOCK3 RHOG RHOG ARPC3 ARPC3 PAK1 PAK1 ARHGEF6 ARHGEF6 RASL10A RASL10A PFN4 PFN4 ELMO1 ELMO1 CTTN CTTN CDC42 CDC42 TRIP10 TRIP10 ABL1 ABL1 ABL2 ABL2 CRKL CRKL TIAM2 TIAM2 IQGAP3 IQGAP3 ACTG1 ACTG1 NEDD9 NEDD9 FAM170B FAM170B VASP VASP WASF2 WASF2 FGR FGR DOCK1 DOCK1 WHAMM WHAMM RIN1 RIN1 WASF3 WASF3 PFN1 PFN1 BRK1 BRK1 RASL12 RASL12 VAV2 VAV2 RHOH RHOH ABI2 ABI2 CYFIP1 CYFIP1 TMEM120B TMEM120B ARHGEF16 ARHGEF16 ACTR3 ACTR3 WIPF1 WIPF1 WIPF2 WIPF2 ARPC1A ARPC1A HCLS1 HCLS1 ARPC5 ARPC5 WAS WAS ABI3 ABI3 WASF1 WASF1 RHOJ RHOJ DIAPH3 DIAPH3 BCR BCR PAK2 PAK2 NCKIPSD NCKIPSD RTKN2 RTKN2 M3WS97_FELCA M3WS97_FELCA ARPC4 ARPC4 PAK4 PAK4 RHOA RHOA M3WUK9_FELCA M3WUK9_FELCA PTK2B PTK2B ABI1 ABI1 LOC101101369 LOC101101369 RHOV RHOV TES TES ARPC5L ARPC5L M3X3Z4_FELCA M3X3Z4_FELCA LOC101100956 LOC101100956 FRMD7 FRMD7 CDC42-2 CDC42-2 M3XEZ6_FELCA M3XEZ6_FELCA ARHGEF7 ARHGEF7 WASL WASL ARHGEF25 ARHGEF25 NCKAP1 NCKAP1 SPIRE2 SPIRE2 EVL EVL HCK HCK FMNL1 FMNL1 PAK6 PAK6 ARHGDIA ARHGDIA GIT1 GIT1 ELMO2 ELMO2 ENSFCAP00000030761 ENSFCAP00000030761 ENSFCAP00000032522 ENSFCAP00000032522 FMNL3 FMNL3 ARHGDIB ARHGDIB SPIRE1 SPIRE1 ACTR2 ACTR2 IQGAP1 IQGAP1 FMNL2 FMNL2 RHOQ RHOQ ENSFCAP00000035896 ENSFCAP00000035896 RHOU RHOU RAPGEF1 RAPGEF1 ENSFCAP00000040844 ENSFCAP00000040844 ENSFCAP00000041826 ENSFCAP00000041826 NCKAP1L NCKAP1L ENSFCAP00000042846 ENSFCAP00000042846 PFN2 PFN2 BAIAP2 BAIAP2 ENSFCAP00000043946 ENSFCAP00000043946 PCLO PCLO FNBP1 FNBP1 CRK CRK ENAH ENAH PAK3 PAK3 BCAR1 BCAR1 ENSFCAP00000048298 ENSFCAP00000048298 ELMO3 ELMO3 FMN1 FMN1 WIPF3 WIPF3 CYFIP2 CYFIP2 ACTR3B ACTR3B SCRN3 SCRN3 FMN2 FMN2 TRIO-2 TRIO-2 FHDC1 FHDC1 RAC2 RAC2 DIAPH2 DIAPH2 MYO1C MYO1C ARHGDIG ARHGDIG RAC1 RAC1 GMIP GMIP IQGAP2 IQGAP2 STAC STAC ENSFCAP00000061258 ENSFCAP00000061258 DIAPH1 DIAPH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2162 aa)
RHOFRas homolog family member F, filopodia associated. (206 aa)
ARHGAP10Rho GTPase activating protein 10. (786 aa)
NCK2Cytoplasmic protein. (380 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
DOCK3Dedicator of cytokinesis 3; Belongs to the DOCK family. (2024 aa)
RHOGRas homolog family member G. (191 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (775 aa)
RASL10ARAS like family 10 member A. (203 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
ELMO1Engulfment and cell motility 1. (742 aa)
CTTNCortactin. (538 aa)
CDC42Uncharacterized protein. (191 aa)
TRIP10Thyroid hormone receptor interactor 10. (603 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
ABL2Tyrosine-protein kinase. (1160 aa)
CRKLCRK like proto-oncogene, adaptor protein. (342 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1694 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1630 aa)
ACTG1Actin gamma 1. (375 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (835 aa)
FAM170BFamily with sequence similarity 170 member B. (332 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (383 aa)
WASF2WASP family member 2. (498 aa)
FGRTyrosine-protein kinase. (527 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1889 aa)
WHAMMWASP homolog associated with actin, golgi membranes and microtubules. (745 aa)
RIN1Ras and Rab interactor 1. (790 aa)
WASF3WASP family member 3. (502 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
RASL12RAS like family 12. (266 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
RHOHRas homolog family member H. (191 aa)
ABI2Abl interactor 2. (542 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
TMEM120BTransmembrane protein 120B. (339 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (950 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
WIPF1WAS/WASL interacting protein family member 1. (507 aa)
WIPF2WAS/WASL interacting protein family member 2. (440 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (397 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (494 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
WASWASP actin nucleation promoting factor. (501 aa)
ABI3ABI family member 3. (365 aa)
WASF1WASP family member 1. (570 aa)
RHOJRas homolog family member J. (236 aa)
DIAPH3Diaphanous related formin 3. (1188 aa)
BCRBCR activator of RhoGEF and GTPase. (1282 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
NCKIPSDNCK interacting protein with SH3 domain. (721 aa)
RTKN2Rhotekin 2. (608 aa)
M3WS97_FELCAArp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (151 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (187 aa)
PAK4Non-specific serine/threonine protein kinase. (592 aa)
RHOARas homolog family member A. (193 aa)
M3WUK9_FELCAUncharacterized protein. (166 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa)
ABI1Abl interactor 1. (508 aa)
LOC101101369Uncharacterized protein; Belongs to the profilin family. (152 aa)
RHOVRas homolog family member V. (236 aa)
TESTestin; Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity); Belongs to the prickle / espinas / testin family. (421 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
M3X3Z4_FELCAUncharacterized protein. (64 aa)
LOC101100956Uncharacterized protein. (129 aa)
FRMD7FERM domain containing 7. (704 aa)
CDC42-2Uncharacterized protein. (191 aa)
M3XEZ6_FELCAUncharacterized protein. (183 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (921 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
ARHGEF25DH domain-containing protein. (619 aa)
NCKAP1NCK associated protein 1. (1134 aa)
SPIRE2Spire type actin nucleation factor 2. (766 aa)
EVLEnah/Vasp-like. (461 aa)
HCKTyrosine-protein kinase. (523 aa)
FMNL1Formin like 1. (1121 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
ARHGDIAUncharacterized protein. (425 aa)
GIT1GIT ArfGAP 1. (770 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
ENSFCAP00000030761Uncharacterized protein; Belongs to the profilin family. (75 aa)
ENSFCAP00000032522Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (132 aa)
FMNL3Formin like 3. (1027 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (200 aa)
SPIRE1Spire type actin nucleation factor 1. (810 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
FMNL2Formin like 2. (1154 aa)
RHOQRas homolog family member Q. (214 aa)
ENSFCAP00000035896Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (140 aa)
RHOURas homolog family member U. (326 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1270 aa)
ENSFCAP00000040844Uncharacterized protein. (598 aa)
ENSFCAP00000041826Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
NCKAP1LNCK associated protein 1 like. (1179 aa)
ENSFCAP00000042846Uncharacterized protein. (204 aa)
PFN2Profilin; Belongs to the profilin family. (188 aa)
BAIAP2BAI1 associated protein 2. (548 aa)
ENSFCAP00000043946Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (118 aa)
PCLOPiccolo presynaptic cytomatrix protein. (5213 aa)
FNBP1Formin binding protein 1. (644 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
ENAHENAH actin regulator. (856 aa)
PAK3P21 (RAC1) activated kinase 3. (589 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (889 aa)
ENSFCAP00000048298Uncharacterized protein. (103 aa)
ELMO3Engulfment and cell motility 3. (720 aa)
FMN1Formin 1. (1417 aa)
WIPF3WAS/WASL interacting protein family member 3. (487 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1335 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (522 aa)
SCRN3Secernin 3. (422 aa)
FMN2Formin 2. (1793 aa)
TRIO-2Uncharacterized protein. (1847 aa)
FHDC1FH2 domain containing 1. (1130 aa)
RAC2Rac family small GTPase 2. (234 aa)
DIAPH2Diaphanous related formin 2. (1101 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1074 aa)
ARHGDIGRho GDP dissociation inhibitor gamma. (252 aa)
RAC1Rac family small GTPase 1. (221 aa)
GMIPGEM interacting protein. (984 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1575 aa)
STACSH3 and cysteine rich domain. (422 aa)
ENSFCAP00000061258Uncharacterized protein. (170 aa)
DIAPH1Diaphanous related formin 1. (1290 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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