(55 nodes) Ephrin receptor signaling pathway, and Sema domain network (Felis catus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RND1	Rho family GTPase 1. (232 aa)
	PLXND1	Plexin D1. (1927 aa)
	CHCHD6	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (2112 aa)
	IRGC	Immunity related GTPase cinema. (435 aa)
	PLXNB1	Plexin B1. (2135 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1112 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (863 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	KIRREL2	Kirre like nephrin family adhesion molecule 2. (861 aa)
	EPHA1	EPH receptor A1. (976 aa)
	EPHA4	EPH receptor A4. (986 aa)
	SEMA7A	Semaphorin 7A; Belongs to the semaphorin family. (769 aa)
	EPHB3	EPH receptor B3. (1000 aa)
	EPHA2	EPH receptor A2. (936 aa)
	PLXNB2	Plexin B2. (1841 aa)
	TLN1	Talin 1. (2558 aa)
	EPHB6	EPH receptor B6. (1012 aa)
	EFNB2	Ephrin B2; Belongs to the ephrin family. (333 aa)
	EPHA7	EPH receptor A7. (1000 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (775 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (749 aa)
	EPHA8	EPH receptor A8. (1003 aa)
	TENM3	Teneurin transmembrane protein 3. (2699 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (773 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1047 aa)
	EPHA3	EPH receptor A3. (984 aa)
	EPHA10	EPH receptor A10. (1008 aa)
	EPHB2	EPH receptor B2. (899 aa)
	ARVCF	ARVCF delta catenin family member. (965 aa)
	PLXNC1	Plexin C1. (1576 aa)
	SEMA6D	Semaphorin 6D; Belongs to the semaphorin family. (1069 aa)
	PLXNA2	Plexin A2. (1911 aa)
	EPHA5	EPH receptor A5. (1043 aa)
	EPHB4	EPH receptor B4. (987 aa)
	DCLK1	Doublecortin like kinase 1. (741 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (228 aa)
	EPHB1	EPH receptor B1. (984 aa)
	EFNA4	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (314 aa)
	NGEF	Neuronal guanine nucleotide exchange factor. (707 aa)
	SEMA6C	Semaphorin 6C; Belongs to the semaphorin family. (1023 aa)
	PIP5K1C	Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (818 aa)
	RHOD	Ras homolog family member D. (210 aa)
	EFNB3	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (340 aa)
	EFNA2	Ephrin A2; Belongs to the ephrin family. (263 aa)
	EPHA6	EPH receptor A6. (1169 aa)
	SEMA4C	Semaphorin 4C; Belongs to the semaphorin family. (1000 aa)
	EFNA3	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (237 aa)
	PLXNA4	Plexin A4. (1893 aa)
	SEMA4A	Semaphorin 4A; Belongs to the semaphorin family. (806 aa)
	FES	Tyrosine-protein kinase Fes/Fps; Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF [...] (861 aa)
	PLXNB3	Plexin B3. (2058 aa)
	EFNA1	Ephrin A1; Belongs to the ephrin family. (357 aa)
	SEMA6B	Semaphorin 6B; Belongs to the semaphorin family. (1296 aa)
	EFNB1	Ephrin B1. (427 aa)
	PLXNA3	Plexin A3. (1872 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARVCF	DCLK1	ENSFCAP00000032294	ENSFCAP00000038809	ARVCF delta catenin family member.	Doublecortin like kinase 1.	0.755
ARVCF	RND1	ENSFCAP00000032294	ENSFCAP00000000076	ARVCF delta catenin family member.	Rho family GTPase 1.	0.415
ARVCF	SEMA6A	ENSFCAP00000032294	ENSFCAP00000025803	ARVCF delta catenin family member.	Semaphorin 6A; Belongs to the semaphorin family.	0.587
ARVCF	SEMA6B	ENSFCAP00000032294	ENSFCAP00000061381	ARVCF delta catenin family member.	Semaphorin 6B; Belongs to the semaphorin family.	0.778
CHCHD6	EFNA5	ENSFCAP00000000909	ENSFCAP00000041998	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Ephrin A5; Belongs to the ephrin family.	0.589
CHCHD6	EFNB2	ENSFCAP00000000909	ENSFCAP00000014190	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Ephrin B2; Belongs to the ephrin family.	0.516
CHCHD6	EPHB6	ENSFCAP00000000909	ENSFCAP00000013849	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	EPH receptor B6.	0.540
CHCHD6	FARP2	ENSFCAP00000000909	ENSFCAP00000002575	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	FERM, ARH/RhoGEF and pleckstrin domain protein 2.	0.663
CHCHD6	FES	ENSFCAP00000000909	ENSFCAP00000053376	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Tyrosine-protein kinase Fes/Fps; Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF [...]	0.959
CHCHD6	KIRREL2	ENSFCAP00000000909	ENSFCAP00000005942	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Kirre like nephrin family adhesion molecule 2.	0.434
CHCHD6	NRP1	ENSFCAP00000000909	ENSFCAP00000005785	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Neuropilin; Belongs to the neuropilin family.	0.998
CHCHD6	PIP5K1C	ENSFCAP00000000909	ENSFCAP00000044617	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma.	0.522
CHCHD6	PLXNA2	ENSFCAP00000000909	ENSFCAP00000036109	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Plexin A2.	0.805
CHCHD6	PLXNA3	ENSFCAP00000000909	ENSFCAP00000061798	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Plexin A3.	0.521
CHCHD6	PLXNA4	ENSFCAP00000000909	ENSFCAP00000051593	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Plexin A4.	0.770
CHCHD6	PLXNB1	ENSFCAP00000000909	ENSFCAP00000001935	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Plexin B1.	0.705
CHCHD6	PLXNB2	ENSFCAP00000000909	ENSFCAP00000011053	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Plexin B2.	0.618
CHCHD6	PLXNB3	ENSFCAP00000000909	ENSFCAP00000054842	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Plexin B3.	0.705
CHCHD6	PLXNC1	ENSFCAP00000000909	ENSFCAP00000033425	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Plexin C1.	0.665
CHCHD6	PLXND1	ENSFCAP00000000909	ENSFCAP00000000090	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Plexin D1.	0.827