(6 nodes) Interleukin-10 signaling, and Cellular response to interleukin-2 network (Felis catus)

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Your Input:
	JAK1	Tyrosine-protein kinase. (1157 aa)
	IL22RA1	Interleukin 22 receptor subunit alpha 1. (581 aa)
	IL10RA	Interleukin 10 receptor subunit alpha. (578 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
	IL22	Interleukin 22. (179 aa)
	IL10RB	Interleukin 10 receptor subunit beta. (390 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL10	IL10RA	ENSFCAP00000012535	ENSFCAP00000010918	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit alpha.	0.996
IL10	IL10RB	ENSFCAP00000012535	ENSFCAP00000060678	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit beta.	0.993
IL10	IL22	ENSFCAP00000012535	ENSFCAP00000014399	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22.	0.802
IL10	IL22RA1	ENSFCAP00000012535	ENSFCAP00000005685	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22 receptor subunit alpha 1.	0.733
IL10	JAK1	ENSFCAP00000012535	ENSFCAP00000001806	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.716
IL10RA	IL10	ENSFCAP00000010918	ENSFCAP00000012535	Interleukin 10 receptor subunit alpha.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.996
IL10RA	IL10RB	ENSFCAP00000010918	ENSFCAP00000060678	Interleukin 10 receptor subunit alpha.	Interleukin 10 receptor subunit beta.	0.992
IL10RA	IL22	ENSFCAP00000010918	ENSFCAP00000014399	Interleukin 10 receptor subunit alpha.	Interleukin 22.	0.798
IL10RA	IL22RA1	ENSFCAP00000010918	ENSFCAP00000005685	Interleukin 10 receptor subunit alpha.	Interleukin 22 receptor subunit alpha 1.	0.778
IL10RA	JAK1	ENSFCAP00000010918	ENSFCAP00000001806	Interleukin 10 receptor subunit alpha.	Tyrosine-protein kinase.	0.999
IL10RB	IL10	ENSFCAP00000060678	ENSFCAP00000012535	Interleukin 10 receptor subunit beta.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.993
IL10RB	IL10RA	ENSFCAP00000060678	ENSFCAP00000010918	Interleukin 10 receptor subunit beta.	Interleukin 10 receptor subunit alpha.	0.992
IL10RB	IL22	ENSFCAP00000060678	ENSFCAP00000014399	Interleukin 10 receptor subunit beta.	Interleukin 22.	0.988
IL10RB	IL22RA1	ENSFCAP00000060678	ENSFCAP00000005685	Interleukin 10 receptor subunit beta.	Interleukin 22 receptor subunit alpha 1.	0.986
IL10RB	JAK1	ENSFCAP00000060678	ENSFCAP00000001806	Interleukin 10 receptor subunit beta.	Tyrosine-protein kinase.	0.977
IL22	IL10	ENSFCAP00000014399	ENSFCAP00000012535	Interleukin 22.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.802
IL22	IL10RA	ENSFCAP00000014399	ENSFCAP00000010918	Interleukin 22.	Interleukin 10 receptor subunit alpha.	0.798
IL22	IL10RB	ENSFCAP00000014399	ENSFCAP00000060678	Interleukin 22.	Interleukin 10 receptor subunit beta.	0.988
IL22	IL22RA1	ENSFCAP00000014399	ENSFCAP00000005685	Interleukin 22.	Interleukin 22 receptor subunit alpha 1.	0.999
IL22RA1	IL10	ENSFCAP00000005685	ENSFCAP00000012535	Interleukin 22 receptor subunit alpha 1.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.733