(50 nodes) Mixed, incl. T cell costimulation, and T cell receptor complex network (Felis catus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD37	Tetraspanin. (281 aa)
	CD4	CD4 molecule. (487 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (615 aa)
	LAG3	Lymphocyte activating 3. (513 aa)
	CD53	Tetraspanin. (215 aa)
	CD274	CD274 molecule. (297 aa)
	PDCD1LG2	Programmed cell death 1 ligand 2. (302 aa)
	LGALS9	Galectin. (356 aa)
	TNFRSF14	TNF receptor superfamily member 14. (476 aa)
	CD80	B-lymphocyte activation antigen B7-1 (CD80). (292 aa)
	ZAP70	Tyrosine-protein kinase. (619 aa)
	CD3D	CD3d molecule. (170 aa)
	CD6	CD6 molecule. (678 aa)
	CD40	CD40 molecule. (324 aa)
	GZMK	Granzyme K; Belongs to the peptidase S1 family. (267 aa)
	CD28	T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
	SIGLEC15	Sialic acid binding Ig like lectin 15. (331 aa)
	CD70	CD70 molecule; Belongs to the tumor necrosis factor family. (190 aa)
	CD52	Uncharacterized protein. (67 aa)
	CD72	CD72 molecule. (371 aa)
	CD8B	T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] (219 aa)
	CTSW	Cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity; Belongs to the peptidase C1 family. (374 aa)
	HAVCR2	Hepatitis A virus cellular receptor 2. (280 aa)
	CD83	CD83 molecule. (391 aa)
	CD40LG	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa)
	PRF1	Perforin 1. (555 aa)
	CD69	CD69 molecule. (199 aa)
	LCK	Tyrosine-protein kinase. (520 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (268 aa)
	CD7	Ig-like domain-containing protein. (276 aa)
	KLRG1	Killer cell lectin like receptor G1. (186 aa)
	FOXP3	Forkhead box P3. (501 aa)
	PDCD1	Programmed cell death 1. (278 aa)
	CD22	CD22 molecule. (845 aa)
	PTPRCAP	Protein tyrosine phosphatase receptor type C associated protein. (205 aa)
	BTLA	B and T lymphocyte associated. (303 aa)
	NKG7	Natural killer cell granule protein 7. (189 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1299 aa)
	ICOSLG	Ig-like domain-containing protein. (356 aa)
	CD160	CD160 molecule. (221 aa)
	GZMA	Granzyme A; Belongs to the peptidase S1 family. (271 aa)
	CD5	CD5 molecule. (524 aa)
	CD8A	T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...] (248 aa)
	CD3E	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (255 aa)
	CD86	B-lymphocyte activation antigen B7-2 (CD86). (332 aa)
	CD58	Uncharacterized protein. (270 aa)
	CD2	CD2 molecule. (376 aa)
	ICOS	Inducible T cell costimulator. (247 aa)
	CD27	CD27 molecule. (296 aa)
	CD247	CD247 molecule. (250 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTLA	CD160	ENSFCAP00000054222	ENSFCAP00000057080	B and T lymphocyte associated.	CD160 molecule.	0.698
BTLA	CD27	ENSFCAP00000054222	ENSFCAP00000061814	B and T lymphocyte associated.	CD27 molecule.	0.700
BTLA	CD274	ENSFCAP00000054222	ENSFCAP00000008385	B and T lymphocyte associated.	CD274 molecule.	0.709
BTLA	CD4	ENSFCAP00000054222	ENSFCAP00000003936	B and T lymphocyte associated.	CD4 molecule.	0.503
BTLA	CD40	ENSFCAP00000054222	ENSFCAP00000013000	B and T lymphocyte associated.	CD40 molecule.	0.702
BTLA	CD40LG	ENSFCAP00000054222	ENSFCAP00000033038	B and T lymphocyte associated.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	0.421
BTLA	CD80	ENSFCAP00000054222	ENSFCAP00000008890	B and T lymphocyte associated.	B-lymphocyte activation antigen B7-1 (CD80).	0.484
BTLA	CD86	ENSFCAP00000054222	ENSFCAP00000059492	B and T lymphocyte associated.	B-lymphocyte activation antigen B7-2 (CD86).	0.425
BTLA	CTLA4	ENSFCAP00000054222	ENSFCAP00000041200	B and T lymphocyte associated.	Cytotoxic T-lymphocyte associated protein 4.	0.681
BTLA	FOXP3	ENSFCAP00000054222	ENSFCAP00000043740	B and T lymphocyte associated.	Forkhead box P3.	0.418
BTLA	HAVCR2	ENSFCAP00000054222	ENSFCAP00000028327	B and T lymphocyte associated.	Hepatitis A virus cellular receptor 2.	0.550
BTLA	ICOS	ENSFCAP00000054222	ENSFCAP00000060601	B and T lymphocyte associated.	Inducible T cell costimulator.	0.660
BTLA	ICOSLG	ENSFCAP00000054222	ENSFCAP00000056949	B and T lymphocyte associated.	Ig-like domain-containing protein.	0.406
BTLA	KLRG1	ENSFCAP00000054222	ENSFCAP00000042910	B and T lymphocyte associated.	Killer cell lectin like receptor G1.	0.457
BTLA	LAG3	ENSFCAP00000054222	ENSFCAP00000006393	B and T lymphocyte associated.	Lymphocyte activating 3.	0.634
BTLA	LGALS9	ENSFCAP00000054222	ENSFCAP00000008538	B and T lymphocyte associated.	Galectin.	0.553
BTLA	PDCD1	ENSFCAP00000054222	ENSFCAP00000045814	B and T lymphocyte associated.	Programmed cell death 1.	0.567
BTLA	PTPN6	ENSFCAP00000054222	ENSFCAP00000003953	B and T lymphocyte associated.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.528
BTLA	PTPRC	ENSFCAP00000054222	ENSFCAP00000056536	B and T lymphocyte associated.	Protein tyrosine phosphatase receptor type C.	0.440
BTLA	TNFRSF14	ENSFCAP00000054222	ENSFCAP00000008830	B and T lymphocyte associated.	TNF receptor superfamily member 14.	0.705