STRINGSTRING
CD4 CD4 LAG3 LAG3 CD274 CD274 PDCD1LG2 PDCD1LG2 LGALS9 LGALS9 TNFRSF14 TNFRSF14 CD80 CD80 ZAP70 ZAP70 CD3D CD3D CD6 CD6 CD40 CD40 GZMK GZMK CD28 CD28 SIGLEC15 SIGLEC15 CD70 CD70 CD8B CD8B CTSW CTSW HAVCR2 HAVCR2 CD83 CD83 CD40LG CD40LG PRF1 PRF1 CD69 CD69 LCK LCK CTLA4 CTLA4 CD7 CD7 KLRG1 KLRG1 FOXP3 FOXP3 PDCD1 PDCD1 PTPRCAP PTPRCAP BTLA BTLA NKG7 NKG7 ICOSLG ICOSLG CD160 CD160 GZMA GZMA CD5 CD5 CD8A CD8A CD3E CD3E CD86 CD86 CD58 CD58 CD2 CD2 ICOS ICOS CD27 CD27 CD247 CD247
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD4CD4 molecule. (487 aa)
LAG3Lymphocyte activating 3. (513 aa)
CD274CD274 molecule. (297 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (302 aa)
LGALS9Galectin. (356 aa)
TNFRSF14TNF receptor superfamily member 14. (476 aa)
CD80B-lymphocyte activation antigen B7-1 (CD80). (292 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
CD3DCD3d molecule. (170 aa)
CD6CD6 molecule. (678 aa)
CD40CD40 molecule. (324 aa)
GZMKGranzyme K; Belongs to the peptidase S1 family. (267 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
SIGLEC15Sialic acid binding Ig like lectin 15. (331 aa)
CD70CD70 molecule; Belongs to the tumor necrosis factor family. (190 aa)
CD8BT-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] (219 aa)
CTSWCathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity; Belongs to the peptidase C1 family. (374 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
CD83CD83 molecule. (391 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa)
PRF1Perforin 1. (555 aa)
CD69CD69 molecule. (199 aa)
LCKTyrosine-protein kinase. (520 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (268 aa)
CD7Ig-like domain-containing protein. (276 aa)
KLRG1Killer cell lectin like receptor G1. (186 aa)
FOXP3Forkhead box P3. (501 aa)
PDCD1Programmed cell death 1. (278 aa)
PTPRCAPProtein tyrosine phosphatase receptor type C associated protein. (205 aa)
BTLAB and T lymphocyte associated. (303 aa)
NKG7Natural killer cell granule protein 7. (189 aa)
ICOSLGIg-like domain-containing protein. (356 aa)
CD160CD160 molecule. (221 aa)
GZMAGranzyme A; Belongs to the peptidase S1 family. (271 aa)
CD5CD5 molecule. (524 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...] (248 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (255 aa)
CD86B-lymphocyte activation antigen B7-2 (CD86). (332 aa)
CD58Uncharacterized protein. (270 aa)
CD2CD2 molecule. (376 aa)
ICOSInducible T cell costimulator. (247 aa)
CD27CD27 molecule. (296 aa)
CD247CD247 molecule. (250 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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