STRINGSTRING
LAG3 LAG3 CD274 CD274 PDCD1LG2 PDCD1LG2 LGALS9 LGALS9 CD80 CD80 CD40 CD40 CD28 CD28 SIGLEC15 SIGLEC15 CD70 CD70 HAVCR2 HAVCR2 CD83 CD83 CD40LG CD40LG CD69 CD69 CTLA4 CTLA4 KLRG1 KLRG1 FOXP3 FOXP3 PDCD1 PDCD1 ICOSLG ICOSLG CD86 CD86 ICOS ICOS CD27 CD27
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LAG3Lymphocyte activating 3. (513 aa)
CD274CD274 molecule. (297 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (302 aa)
LGALS9Galectin. (356 aa)
CD80B-lymphocyte activation antigen B7-1 (CD80). (292 aa)
CD40CD40 molecule. (324 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
SIGLEC15Sialic acid binding Ig like lectin 15. (331 aa)
CD70CD70 molecule; Belongs to the tumor necrosis factor family. (190 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
CD83CD83 molecule. (391 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa)
CD69CD69 molecule. (199 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (268 aa)
KLRG1Killer cell lectin like receptor G1. (186 aa)
FOXP3Forkhead box P3. (501 aa)
PDCD1Programmed cell death 1. (278 aa)
ICOSLGIg-like domain-containing protein. (356 aa)
CD86B-lymphocyte activation antigen B7-2 (CD86). (332 aa)
ICOSInducible T cell costimulator. (247 aa)
CD27CD27 molecule. (296 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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