STRINGSTRING
GLI1 GLI1 SPOP SPOP EVC2 EVC2 EVC EVC STK36 STK36 GLIS1 GLIS1 PTCH2 PTCH2 GLI3 GLI3 KIF7 KIF7 IHH IHH BOC BOC HHAT HHAT IQCE IQCE KIF27 KIF27 CDON CDON DLG5 DLG5 HHIP HHIP SPOPL SPOPL ENSFCAP00000041067 ENSFCAP00000041067 CUL3 CUL3 PTCH1 PTCH1 DHH DHH TTC23L TTC23L SUFU SUFU PGM1 PGM1 GLI2 GLI2 GAS1 GAS1 SMO SMO SHH SHH SCUBE2 SCUBE2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLI1GLI family zinc finger 1. (1105 aa)
SPOPSpeckle type BTB/POZ protein. (374 aa)
EVC2EvC ciliary complex subunit 2. (1298 aa)
EVCEvC ciliary complex subunit 1. (943 aa)
STK36Serine/threonine kinase 36. (1311 aa)
GLIS1GLIS family zinc finger 1. (793 aa)
PTCH2Patched 2. (1207 aa)
GLI3GLI family zinc finger 3. (1578 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1432 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1112 aa)
HHATHedgehog acyltransferase; Belongs to the membrane-bound acyltransferase family. (491 aa)
IQCEIQ motif containing E. (592 aa)
KIF27Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1400 aa)
CDONCell adhesion associated, oncogene regulated. (1283 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1921 aa)
HHIPHedgehog interacting protein. (682 aa)
SPOPLSpeckle type BTB/POZ protein like. (392 aa)
ENSFCAP00000041067Uncharacterized protein. (1060 aa)
CUL3Cullin 3; Belongs to the cullin family. (857 aa)
PTCH1Patched 1. (1451 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
TTC23LTetratricopeptide repeat domain 23 like. (412 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (490 aa)
PGM1EF-hand calcium binding domain 7. (1049 aa)
GLI2Uncharacterized protein. (161 aa)
GAS1Growth arrest specific 1. (369 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (795 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (556 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (1024 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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