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INHBE INHBE SMAD1 SMAD1 BMP5 BMP5 TGFB1 TGFB1 AMHR2 AMHR2 INHA INHA CHRD CHRD ACVR1 ACVR1 SNX16 SNX16 SMAD6 SMAD6 BMPR2 BMPR2 SMURF1 SMURF1 MSTN MSTN GDF11 GDF11 SMURF2 SMURF2 SKI SKI BMP15 BMP15 ACVR1B ACVR1B BMPR1A BMPR1A BMP6 BMP6 ZFYVE9 ZFYVE9 BMP10 BMP10 ACVR1C ACVR1C BMP2 BMP2 SMAD4 SMAD4 FST FST SMAD3 SMAD3 GDF5 GDF5 NBL1 NBL1 SKIL SKIL ACVRL1 ACVRL1 ACVR2A ACVR2A BMPR1B BMPR1B SOSTDC1 SOSTDC1 INHBB INHBB SMAD9 SMAD9 SMAD7 SMAD7 INHBA INHBA LOC101092676 LOC101092676 GREM2 GREM2 NOG NOG TGFBR1 TGFBR1 BMP8B BMP8B SMAD5 SMAD5 BMP4 BMP4 GDF7 GDF7 LOC111559734 LOC111559734 PRR13 PRR13 ZFYVE16 ZFYVE16 AMH AMH ACVR2B ACVR2B SMAD2 SMAD2 TGFBR2 TGFBR2 ENSFCAP00000061110 ENSFCAP00000061110
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INHBEInhibin subunit beta E. (349 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (483 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (954 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SNX16Sorting nexin 16. (344 aa)
SMAD6Mothers against decapentaplegic homolog. (497 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
MSTNMyostatin. (375 aa)
GDF11Growth differentiation factor 11. (404 aa)
SMURF2E3 ubiquitin-protein ligase. (748 aa)
SKISKI proto-oncogene. (730 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMP6Bone morphogenetic protein 6. (502 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1424 aa)
BMP10TGF_BETA_2 domain-containing protein. (424 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FSTFollistatin. (423 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
GDF5Growth differentiation factor 5. (499 aa)
NBL1NBL1, DAN family BMP antagonist. (176 aa)
SKILSKI like proto-oncogene. (686 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (588 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
INHBBInhibin subunit beta B. (407 aa)
SMAD9Mothers against decapentaplegic homolog. (430 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa)
LOC101092676TGF_BETA_2 domain-containing protein. (410 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (187 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
BMP8BTGF_BETA_2 domain-containing protein. (402 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
GDF7Growth differentiation factor 7. (455 aa)
LOC111559734Bone morphogenetic protein 7. (426 aa)
PRR13Proline rich 13. (144 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1538 aa)
AMHAnti-Mullerian hormone. (800 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa)
SMAD2Mothers against decapentaplegic homolog. (721 aa)
TGFBR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (604 aa)
ENSFCAP00000061110TGF_BETA_2 domain-containing protein. (362 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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