30 items (Felis catus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	CCNE1	Cyclin E1; Belongs to the cyclin family. (410 aa)
	TFDP2	Transcription factor. (386 aa)
	CCNA1	Cyclin A1; Belongs to the cyclin family. (421 aa)
	E2F1	E2F transcription factor 1. (436 aa)
	E2F4	E2F transcription factor 4. (406 aa)
	E2F2	E2F transcription factor 2. (442 aa)
	RBL1	RB transcriptional corepressor like 1. (1068 aa)
	CKS2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	CDK4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
	CCNG1	Cyclin G1; Belongs to the cyclin family. (295 aa)
	CCNG2	Cyclin G2; Belongs to the cyclin family. (343 aa)
	CDKN2D	Cyclin dependent kinase inhibitor 2D. (166 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (406 aa)
	RB1	RB transcriptional corepressor 1. (930 aa)
	CKS1B	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	CDKN2C	Cyclin dependent kinase inhibitor 2C. (168 aa)
	ENSFCAP00000030965	Protein kinase domain-containing protein. (104 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	ENSFCAP00000037196	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (56 aa)
	RBL2	RB transcriptional corepressor like 2. (1139 aa)
	CCND3	Cyclin D3; Belongs to the cyclin family. (292 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
	CDKN1C	Cyclin dependent kinase inhibitor 1C. (264 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
	TFDP1	Transcription factor. (423 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (312 aa)
	CA13	Carbonic anhydrase 13. (534 aa)
	E2F3	E2F transcription factor 3. (523 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CA13	CCNA1	ENSFCAP00000062084	ENSFCAP00000004291	Carbonic anhydrase 13.	Cyclin A1; Belongs to the cyclin family.	0.679
CA13	CCND1	ENSFCAP00000062084	ENSFCAP00000051341	Carbonic anhydrase 13.	Cyclin D1; Belongs to the cyclin family.	0.591
CA13	CCND2	ENSFCAP00000062084	ENSFCAP00000042249	Carbonic anhydrase 13.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.486
CA13	CCND3	ENSFCAP00000062084	ENSFCAP00000039087	Carbonic anhydrase 13.	Cyclin D3; Belongs to the cyclin family.	0.486
CA13	CCNE1	ENSFCAP00000062084	ENSFCAP00000001506	Carbonic anhydrase 13.	Cyclin E1; Belongs to the cyclin family.	0.628
CA13	CCNE2	ENSFCAP00000062084	ENSFCAP00000021803	Carbonic anhydrase 13.	Cyclin E2; Belongs to the cyclin family.	0.664
CA13	CDK2	ENSFCAP00000062084	ENSFCAP00000031371	Carbonic anhydrase 13.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.568
CA13	CDK4	ENSFCAP00000062084	ENSFCAP00000018088	Carbonic anhydrase 13.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.515
CA13	CDK6	ENSFCAP00000062084	ENSFCAP00000049545	Carbonic anhydrase 13.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.551
CA13	CDKN1A	ENSFCAP00000062084	ENSFCAP00000020450	Carbonic anhydrase 13.	Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...]	0.508
CA13	CDKN1B	ENSFCAP00000062084	ENSFCAP00000044526	Carbonic anhydrase 13.	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.	0.615
CA13	CDKN1C	ENSFCAP00000062084	ENSFCAP00000043917	Carbonic anhydrase 13.	Cyclin dependent kinase inhibitor 1C.	0.615
CA13	CKS1B	ENSFCAP00000062084	ENSFCAP00000027030	Carbonic anhydrase 13.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.400
CA13	CKS2	ENSFCAP00000062084	ENSFCAP00000017677	Carbonic anhydrase 13.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.400
CA13	E2F1	ENSFCAP00000062084	ENSFCAP00000004643	Carbonic anhydrase 13.	E2F transcription factor 1.	0.637
CA13	E2F2	ENSFCAP00000062084	ENSFCAP00000010812	Carbonic anhydrase 13.	E2F transcription factor 2.	0.753
CA13	E2F3	ENSFCAP00000062084	ENSFCAP00000062212	Carbonic anhydrase 13.	E2F transcription factor 3.	0.737
CA13	E2F4	ENSFCAP00000062084	ENSFCAP00000008592	Carbonic anhydrase 13.	E2F transcription factor 4.	0.956
CA13	ENSFCAP00000030965	ENSFCAP00000062084	ENSFCAP00000030965	Carbonic anhydrase 13.	Protein kinase domain-containing protein.	0.515
CA13	ENSFCAP00000037196	ENSFCAP00000062084	ENSFCAP00000037196	Carbonic anhydrase 13.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.400