STRINGSTRING
CCNE1 CCNE1 TFDP2 TFDP2 CCNA1 CCNA1 E2F1 E2F1 E2F4 E2F4 E2F2 E2F2 RBL1 RBL1 CKS2 CKS2 CDK4 CDK4 CCNG1 CCNG1 CCNG2 CCNG2 CDKN2D CDKN2D CDKN1A CDKN1A CCNE2 CCNE2 RB1 RB1 CKS1B CKS1B CDKN2C CDKN2C ENSFCAP00000030965 ENSFCAP00000030965 CDK2 CDK2 ENSFCAP00000037196 ENSFCAP00000037196 RBL2 RBL2 CCND3 CCND3 CCND2 CCND2 CDKN1C CDKN1C CDKN1B CDKN1B TFDP1 TFDP1 CDK6 CDK6 CCND1 CCND1 CA13 CA13 E2F3 E2F3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
TFDP2Transcription factor. (386 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
E2F1E2F transcription factor 1. (436 aa)
E2F4E2F transcription factor 4. (406 aa)
E2F2E2F transcription factor 2. (442 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (343 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (406 aa)
RB1RB transcriptional corepressor 1. (930 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
ENSFCAP00000030965Protein kinase domain-containing protein. (104 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ENSFCAP00000037196Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (56 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (264 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
TFDP1Transcription factor. (423 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
CA13Carbonic anhydrase 13. (534 aa)
E2F3E2F transcription factor 3. (523 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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