(68 nodes) Mixed, incl. Small-subunit processome, and Positive regulation of rRNA processing network (Felis catus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RIOK3	Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
	NAT10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
	PDCD11	Programmed cell death 11. (1871 aa)
	NOB1	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (420 aa)
	FBL	Fibrillarin. (315 aa)
	WDR3	WD repeat domain 3. (961 aa)
	WDR46	WD repeat domain 46. (612 aa)
	EMG1	EMG1 N1-specific pseudouridine methyltransferase. (244 aa)
	PWP2	Uncharacterized protein. (1036 aa)
	BUD23	BUD23 rRNA methyltransferase and ribosome maturation factor. (281 aa)
	KRI1	KRI1 homolog. (700 aa)
	WDR75	WD repeat domain 75. (830 aa)
	UTP20	UTP20 small subunit processome component. (2783 aa)
	TSR1	TSR1 ribosome maturation factor. (802 aa)
	NOL6	Nucleolar protein 6. (1146 aa)
	DDX10	RNA helicase. (888 aa)
	UTP3	UTP3 small subunit processome component. (481 aa)
	LTV1	LTV1 ribosome biogenesis factor. (474 aa)
	RRP9	Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein. (475 aa)
	RRP36	Ribosomal RNA processing 36. (251 aa)
	DDX52	DExD-box helicase 52. (597 aa)
	BMS1	BMS1 ribosome biogenesis factor. (1286 aa)
	UTP4	UTP4 small subunit processome component. (698 aa)
	TBL3	Transducin beta like 3. (806 aa)
	PMEL	Premelanosome protein. (670 aa)
	NOP56	NOP56 ribonucleoprotein. (597 aa)
	RCL1	RNA terminal phosphate cyclase like 1. (373 aa)
	UTP25	UTP25 small subunit processor component. (750 aa)
	UTP6	UTP6 small subunit processome component. (597 aa)
	WDR43	WD repeat domain 43. (680 aa)
	BYSL	Bystin like. (436 aa)
	ESF1	ESF1 nucleolar pre-rRNA processing protein homolog. (854 aa)
	DNTTIP2	Deoxynucleotidyltransferase terminal interacting protein 2. (771 aa)
	MPHOSPH10	U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family. (758 aa)
	UTP15	UTP15 small subunit processome component. (518 aa)
	RTCA	RNA 3'-terminal phosphate cyclase. (402 aa)
	RIOK2	RIO kinase 2. (552 aa)
	FCF1	PINc domain-containing protein. (198 aa)
	IMP4	IMP U3 small nucleolar ribonucleoprotein 4. (291 aa)
	WDR36	WD repeat domain 36. (894 aa)
	ENSFCAP00000025809	Uncharacterized protein. (191 aa)
	NOM1	Nucleolar protein with MIF4G domain 1. (919 aa)
	UTP23	UTP23 small subunit processome component. (247 aa)
	RRP7A	Ribosomal RNA processing 7 homolog A. (355 aa)
	DIMT1	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (313 aa)
	METTL27	Methyltransferase like 27. (312 aa)
	SNU13	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (132 aa)
	GLMN	Glomulin, FKBP associated protein. (600 aa)
	DHX37	DEAH-box helicase 37. (1152 aa)
	UTP14A	Uncharacterized protein. (771 aa)
	ABT1	Activator of basal transcription 1. (275 aa)
	MCC	MCC regulator of WNT signaling pathway. (1015 aa)
	AATF	Apoptosis antagonizing transcription factor. (568 aa)
	KRR1	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (386 aa)
	UTP11	UTP11 small subunit processome component. (310 aa)
	PNO1	Partner of NOB1 homolog. (260 aa)
	UTP18	UTP18 small subunit processome component. (596 aa)
	DCAF13	DDB1 and CUL4 associated factor 13. (450 aa)
	DDX47	DEAD-box helicase 47; Belongs to the DEAD box helicase family. (476 aa)
	ENSFCAP00000054068	Uncharacterized protein. (137 aa)
	LOC101087740	WD_REPEATS_REGION domain-containing protein. (623 aa)
	NGDN	Neuroguidin. (289 aa)
	NOP58	NOP58 ribonucleoprotein. (538 aa)
	NOP14	NOP14 nucleolar protein. (895 aa)
	DDX49	DEAD-box helicase 49; Belongs to the DEAD box helicase family. (512 aa)
	HEATR1	HEAT repeat containing 1. (2140 aa)
	NOL10	Nucleolar protein 10. (734 aa)
	NOC4L	Nucleolar complex associated 4 homolog. (593 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AATF	ABT1	ENSFCAP00000050920	ENSFCAP00000044886	Apoptosis antagonizing transcription factor.	Activator of basal transcription 1.	0.700
AATF	BMS1	ENSFCAP00000050920	ENSFCAP00000010424	Apoptosis antagonizing transcription factor.	BMS1 ribosome biogenesis factor.	0.989
AATF	BYSL	ENSFCAP00000050920	ENSFCAP00000017980	Apoptosis antagonizing transcription factor.	Bystin like.	0.989
AATF	DCAF13	ENSFCAP00000050920	ENSFCAP00000052950	Apoptosis antagonizing transcription factor.	DDB1 and CUL4 associated factor 13.	0.989
AATF	DDX10	ENSFCAP00000050920	ENSFCAP00000006717	Apoptosis antagonizing transcription factor.	RNA helicase.	0.919
AATF	DDX47	ENSFCAP00000050920	ENSFCAP00000053651	Apoptosis antagonizing transcription factor.	DEAD-box helicase 47; Belongs to the DEAD box helicase family.	0.851
AATF	DDX49	ENSFCAP00000050920	ENSFCAP00000058065	Apoptosis antagonizing transcription factor.	DEAD-box helicase 49; Belongs to the DEAD box helicase family.	0.727
AATF	DDX52	ENSFCAP00000050920	ENSFCAP00000009817	Apoptosis antagonizing transcription factor.	DExD-box helicase 52.	0.906
AATF	DIMT1	ENSFCAP00000050920	ENSFCAP00000034787	Apoptosis antagonizing transcription factor.	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	0.587
AATF	DNTTIP2	ENSFCAP00000050920	ENSFCAP00000020002	Apoptosis antagonizing transcription factor.	Deoxynucleotidyltransferase terminal interacting protein 2.	0.981
AATF	EMG1	ENSFCAP00000050920	ENSFCAP00000003954	Apoptosis antagonizing transcription factor.	EMG1 N1-specific pseudouridine methyltransferase.	0.981
AATF	ENSFCAP00000025809	ENSFCAP00000050920	ENSFCAP00000025809	Apoptosis antagonizing transcription factor.	Uncharacterized protein.	0.901
AATF	ENSFCAP00000054068	ENSFCAP00000050920	ENSFCAP00000054068	Apoptosis antagonizing transcription factor.	Uncharacterized protein.	0.867
AATF	ESF1	ENSFCAP00000050920	ENSFCAP00000019877	Apoptosis antagonizing transcription factor.	ESF1 nucleolar pre-rRNA processing protein homolog.	0.925
AATF	FBL	ENSFCAP00000050920	ENSFCAP00000002787	Apoptosis antagonizing transcription factor.	Fibrillarin.	0.964
AATF	FCF1	ENSFCAP00000050920	ENSFCAP00000023542	Apoptosis antagonizing transcription factor.	PINc domain-containing protein.	0.901
AATF	GLMN	ENSFCAP00000050920	ENSFCAP00000041957	Apoptosis antagonizing transcription factor.	Glomulin, FKBP associated protein.	0.871
AATF	HEATR1	ENSFCAP00000050920	ENSFCAP00000059160	Apoptosis antagonizing transcription factor.	HEAT repeat containing 1.	0.977
AATF	IMP4	ENSFCAP00000050920	ENSFCAP00000024822	Apoptosis antagonizing transcription factor.	IMP U3 small nucleolar ribonucleoprotein 4.	0.986
AATF	KRI1	ENSFCAP00000050920	ENSFCAP00000004514	Apoptosis antagonizing transcription factor.	KRI1 homolog.	0.514