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| | CYP1A2 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (512 aa) |
| | DHRS3 | Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa) |
| | POR | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (715 aa) |
| | HSD17B6 | Hydroxysteroid 17-beta dehydrogenase 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa) |
| | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (508 aa) |
| | RBP2 | Retinol binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (142 aa) |
| | CYP4V2 | Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. (525 aa) |
| | FBXO43 | F-box protein 43. (700 aa) |
| | CYP24A1 | Cytochrome P450 family 24 subfamily A member 1. (492 aa) |
| | IDI1 | Isopentenyl-diphosphate delta isomerase 1. (281 aa) |
| | HSD17B3 | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (306 aa) |
| | RETSAT | Retinol saturase. (610 aa) |
| | PNPLA4 | Patatin like phospholipase domain containing 4. (290 aa) |
| | DHCR7 | 7-dehydrocholesterol reductase. (475 aa) |
| | CYP21A2 | Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. (494 aa) |
| | GC | GC vitamin D binding protein. (474 aa) |
| | BCO1 | Beta-carotene oxygenase 1. (546 aa) |
| | TM7SF2 | Transmembrane 7 superfamily member 2. (418 aa) |
| | AKR1D1 | Aldo-keto reductase family 1 member D1. (326 aa) |
| | CYP4X1 | Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (507 aa) |
| | CYP26A1 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (501 aa) |
| | CYP7A1 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa) |
| | LOC101089816 | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) |
| | ALDH1A1 | Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family. (501 aa) |
| | RDH8 | Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa) |
| | CYP26C1 | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa) |
| | CYP7B1 | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (510 aa) |
| | ALDH1A3 | Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa) |
| | CYP11A1 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa) |
| | TTR | Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (146 aa) |
| | CYP2R1 | Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (501 aa) |
| | HSD17B1 | Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa) |
| | LOC101091418 | Uncharacterized protein. (314 aa) |
| | HSD11B1L | Hydroxysteroid 11-beta dehydrogenase 1 like. (302 aa) |
| | HMGCS1 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (537 aa) |
| | CYP2S1 | Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (493 aa) |
| | CYP27C1 | Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (580 aa) |
| | RDH5 | Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa) |
| | ERG28 | Ergosterol biosynthesis 28 homolog. (140 aa) |
| | EPHX2 | Epoxide hydrolase 2. (554 aa) |
| | SULT2B1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (343 aa) |
| | RDH16 | Retinol dehydrogenase 16; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (344 aa) |
| | CYP27B1 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa) |
| | LSS | Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (733 aa) |
| | SDR16C5 | Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (326 aa) |
| | SULT1E1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (320 aa) |
| | LOC101089311 | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) |
| | UGT1A | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa) |
| | CYP8B1 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa) |
| | CYP19A1 | Cytochrome P450 family 19 subfamily A polypeptide 1 transcript variant 1; Belongs to the cytochrome P450 family. (506 aa) |
| | RDH10 | Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa) |
| | LOC101089804 | Uncharacterized protein; Belongs to the cytochrome P450 family. (486 aa) |
| | HSD17B7 | Hydroxysteroid 17-beta dehydrogenase 7. (331 aa) |
| | EBP | EXPERA domain-containing protein. (230 aa) |
| | CYP20A1 | Cytochrome P450 family 20 subfamily A member 1. (468 aa) |
| | VDR | Vitamin D receptor. (441 aa) |
| | CYP51A1 | Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (508 aa) |
| | SQLE | Squalene epoxidase. (574 aa) |
| | STS | Steroid sulfatase. (584 aa) |
| | SRD5A3 | Steroid 5 alpha-reductase 3. (318 aa) |
| | LRAT | Lecithin retinol acyltransferase. (484 aa) |
| | DHRSX | Dehydrogenase/reductase X-linked. (330 aa) |
| | CH25H | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (242 aa) |
| | HSD3B2 | 3 beta-hydroxysteroid dehydrogenase; Belongs to the 3-beta-HSD family. (373 aa) |
| | FDPS | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (420 aa) |
| | ENSFCAP00000025991 | Uncharacterized protein; Belongs to the cytochrome P450 family. (134 aa) |
| | CYP4F8 | Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family. (479 aa) |
| | ENSFCAP00000028450 | Uncharacterized protein. (475 aa) |
| | HSD11B1 | Hydroxysteroid 11-beta dehydrogenase 1. (292 aa) |
| | MSMO1 | Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (293 aa) |
| | RBP1 | Retinol binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa) |
| | DHRS9 | Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa) |
| | AWAT2 | Acyl-CoA wax alcohol acyltransferase 2. (341 aa) |
| | CYP39A1 | Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (495 aa) |
| | HSD11B2 | Hydroxysteroid 11-beta dehydrogenase 2. (405 aa) |
| | CBR3 | Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa) |
| | SDR42E1 | Short chain dehydrogenase/reductase family 42E, member 1; Belongs to the 3-beta-HSD family. (393 aa) |
| | STRA6 | Stimulated by retinoic acid 6. (700 aa) |
| | HMGCR | 3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa) |
| | LOC105259649 | Uncharacterized protein; Belongs to the cytochrome P450 family. (552 aa) |
| | CYP3A131 | Uncharacterized protein. (503 aa) |
| | CYP2E2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa) |
| | LOC101094994 | Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa) |
| | NSDHL | NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (361 aa) |
| | LIPA | Lipase A, lysosomal acid type. (491 aa) |
| | ALDH1A2 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (549 aa) |
| | LOC101089561 | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) |
| | FDFT1 | Farnesyl-diphosphate farnesyltransferase 1. (472 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa) |
| | RBP4 | Retinol binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. (372 aa) |
| | MVK | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (447 aa) |
| | DIP2C | Disco interacting protein 2 homolog C. (1622 aa) |
| | SC5D | Sterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa) |
| | LOC101089396 | Uncharacterized protein; Belongs to the cytochrome P450 family. (431 aa) |
| | LOC101097790 | Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa) |
| | SRD5A2 | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa) |
| | CYP4B1 | Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa) |
| | CYP2D6 | Uncharacterized protein; Belongs to the cytochrome P450 family. (541 aa) |
| | PMVK | Phosphomevalonate kinase. (211 aa) |
| | HSD17B2 | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (387 aa) |
| | CYP3A132 | Uncharacterized protein. (508 aa) |
| | SIGMAR1 | Sigma non-opioid intracellular receptor 1. (271 aa) |
| | R3HDM4 | R3H domain containing 4. (299 aa) |
| | MVD | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (445 aa) |
| | SOAT1 | O-acyltransferase. (566 aa) |
| | CYP27A1 | Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (548 aa) |
| | FAXDC2 | Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (368 aa) |
| | RPE65 | Retinoid isomerohydrolase RPE65. (628 aa) |
| | AKR1C3 | Aldo_ket_red domain-containing protein. (419 aa) |
| | CYP2J2 | Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (502 aa) |
| | SRD5A1 | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (288 aa) |
| | RGS22 | Regulator of G protein signaling 22. (1257 aa) |
| | RDH12 | Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (322 aa) |
| | HSD3B7 | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. (385 aa) |
| | LOC101083281 | Uncharacterized protein. (480 aa) |
| | AS3MT | Arsenite methyltransferase. (391 aa) |
| | LOC101087662 | UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. (555 aa) |
| | DHCR24 | 24-dehydrocholesterol reductase. (571 aa) |
| | LOC101087695 | Uncharacterized protein. (476 aa) |
| | RDH11 | Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (426 aa) |
| | SOAT2 | O-acyltransferase. (538 aa) |
| | CYP46A1 | Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (521 aa) |
