(16 nodes) Xenobiotics, and Retinoic acid binding network (Felis catus)

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Your Input:
	CYP1A2	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (512 aa)
	LOC101089816	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	CYP26C1	Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
	LOC101091418	Uncharacterized protein. (314 aa)
	HSD11B1L	Hydroxysteroid 11-beta dehydrogenase 1 like. (302 aa)
	CYP2S1	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (493 aa)
	UGT1A	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
	CBR3	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
	LOC105259649	Uncharacterized protein; Belongs to the cytochrome P450 family. (552 aa)
	CYP3A131	Uncharacterized protein. (503 aa)
	CYP2E2	Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa)
	LOC101094994	Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
	LOC101089561	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
	LOC101083281	Uncharacterized protein. (480 aa)
	LOC101087662	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. (555 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBR3	CYP2E2	ENSFCAP00000034785	ENSFCAP00000037780	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.919
CBR3	LOC101087662	ENSFCAP00000034785	ENSFCAP00000060646	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.905
CBR3	LOC101089561	ENSFCAP00000034785	ENSFCAP00000042971	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.919
CBR3	LOC101089816	ENSFCAP00000034785	ENSFCAP00000007933	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.919
CBR3	UGT1A	ENSFCAP00000034785	ENSFCAP00000017580	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.910
CYP1A2	CYP26B1	ENSFCAP00000000315	ENSFCAP00000045334	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	0.942
CYP1A2	CYP26C1	ENSFCAP00000000315	ENSFCAP00000009218	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family.	0.931
CYP1A2	CYP2E2	ENSFCAP00000000315	ENSFCAP00000037780	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.938
CYP1A2	CYP2S1	ENSFCAP00000000315	ENSFCAP00000012144	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family.	0.931
CYP1A2	CYP3A131	ENSFCAP00000000315	ENSFCAP00000037675	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Uncharacterized protein.	0.964
CYP1A2	LOC101083281	ENSFCAP00000000315	ENSFCAP00000059879	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Uncharacterized protein.	0.938
CYP1A2	LOC101087662	ENSFCAP00000000315	ENSFCAP00000060646	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.953
CYP1A2	LOC101089561	ENSFCAP00000000315	ENSFCAP00000042971	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.923
CYP1A2	LOC101089816	ENSFCAP00000000315	ENSFCAP00000007933	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.924
CYP1A2	LOC101094994	ENSFCAP00000000315	ENSFCAP00000038126	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.937
CYP1A2	LOC105259649	ENSFCAP00000000315	ENSFCAP00000036747	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.933
CYP1A2	UGT1A	ENSFCAP00000000315	ENSFCAP00000017580	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.973
CYP26B1	CYP1A2	ENSFCAP00000045334	ENSFCAP00000000315	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	0.942
CYP26B1	CYP26C1	ENSFCAP00000045334	ENSFCAP00000009218	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family.	0.915
CYP26B1	CYP2S1	ENSFCAP00000045334	ENSFCAP00000012144	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family.	0.930