(69 nodes) Glutathione metabolism, and Detoxification of Reactive Oxygen Species network (Felis catus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PRDX2	Peroxiredoxin 2. (198 aa)
	TXN2	Thioredoxin 2. (163 aa)
	GGT1	Uncharacterized protein. (568 aa)
	GGT7	Gamma-glutamyltransferase 7. (748 aa)
	MGST3	Microsomal glutathione S-transferase 3. (190 aa)
	LOC101096317	Uncharacterized protein; Belongs to the GST superfamily. (223 aa)
	GSTK1	Glutathione S-transferase kappa 1. (423 aa)
	GGCT	Uncharacterized protein. (188 aa)
	MSRA	Methionine sulfoxide reductase A. (246 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (606 aa)
	KEAP1	Kelch like ECH associated protein 1. (624 aa)
	NME8	NME/NM23 family member 8. (590 aa)
	MAP3K15	Mitogen-activated protein kinase kinase kinase 15. (275 aa)
	CHAC1	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (222 aa)
	GSTM3	Glutathione S-transferase. (226 aa)
	GPX5	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
	GSTO1	Glutathione S-transferase omega 1. (241 aa)
	LOC101083370	Uncharacterized protein. (257 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	PRDX5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (196 aa)
	MGST2	Microsomal glutathione S-transferase 2. (146 aa)
	M3X280_FELCA	MsrB domain-containing protein. (257 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (643 aa)
	GLRX	Glutaredoxin domain-containing protein. (106 aa)
	CHAC2	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (184 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	LOC101084793	Uncharacterized protein. (222 aa)
	GPX4	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (196 aa)
	GGT5	Gamma-glutamyltransferase 5. (570 aa)
	TXNIP	Thioredoxin interacting protein. (391 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
	GSTM4	Glutathione S-transferase mu 4; Belongs to the GST superfamily. (212 aa)
	LOC101083114	Uncharacterized protein; Belongs to the GST superfamily. (296 aa)
	ENSFCAP00000031227	Uncharacterized protein. (152 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (205 aa)
	PRDX6	Peroxiredoxin 6. (224 aa)
	GSTT4	Glutathione S-transferase theta 4; Belongs to the GST superfamily. (274 aa)
	ENSFCAP00000033495	Sod_Cu domain-containing protein. (182 aa)
	EPHX1	Epoxide hydrolase 1. (565 aa)
	SOD1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (155 aa)
	GSTA4	Glutathione S-transferase alpha 4. (222 aa)
	BTBD10	BTB domain containing 10. (454 aa)
	PRDX1	Peroxiredoxin 1. (229 aa)
	TXNDC8	Thioredoxin domain containing 8. (127 aa)
	GPX2	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
	GPX3	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
	TXN	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (553 aa)
	GCLM	Glutamate-cysteine ligase modifier subunit. (274 aa)
	GSR	Glutathione-disulfide reductase. (561 aa)
	MSRB3	Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. (297 aa)
	TXNDC2	Thioredoxin domain-containing protein. (617 aa)
	SRXN1	Sulfiredoxin. (137 aa)
	GGT6	Gamma-glutamyltransferase 6. (586 aa)
	SOD3	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (246 aa)
	NME9	NME/NM23 family member 9; Belongs to the NDK family. (397 aa)
	SMPDL3A	Sphingomyelin phosphodiesterase acid like 3A. (506 aa)
	GPX6	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
	ENSFCAP00000054469	Thioredoxin domain-containing protein. (97 aa)
	GSS	Glutathione synthetase. (525 aa)
	LAP3	Leucine aminopeptidase 3. (537 aa)
	OPLAH	5-oxoprolinase, ATP-hydrolysing. (1314 aa)
	GSTP1	Uncharacterized protein; Belongs to the GST superfamily. (438 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (616 aa)
	ENSFCAP00000057621	Uncharacterized protein. (151 aa)
	PRDX3	Peroxiredoxin 3. (270 aa)
	ENSFCAP00000059741	Ig-like domain-containing protein. (191 aa)
	GLRX2	Glutaredoxin domain-containing protein. (290 aa)
	MGST1	Microsomal glutathione S-transferase 1. (176 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTBD10	GSTT4	ENSFCAP00000036950	ENSFCAP00000033447	BTB domain containing 10.	Glutathione S-transferase theta 4; Belongs to the GST superfamily.	0.905
BTBD10	PRDX1	ENSFCAP00000036950	ENSFCAP00000037920	BTB domain containing 10.	Peroxiredoxin 1.	0.438
BTBD10	SMPDL3A	ENSFCAP00000036950	ENSFCAP00000052928	BTB domain containing 10.	Sphingomyelin phosphodiesterase acid like 3A.	0.880
CAT	ENSFCAP00000033495	ENSFCAP00000057562	ENSFCAP00000033495	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Sod_Cu domain-containing protein.	0.825
CAT	GCLC	ENSFCAP00000057562	ENSFCAP00000021130	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutamate-cysteine ligase catalytic subunit.	0.530
CAT	GPX1	ENSFCAP00000057562	ENSFCAP00000032344	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.427
CAT	GPX2	ENSFCAP00000057562	ENSFCAP00000039630	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.427
CAT	GPX3	ENSFCAP00000057562	ENSFCAP00000039842	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.427
CAT	GPX4	ENSFCAP00000057562	ENSFCAP00000022468	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.542
CAT	GPX5	ENSFCAP00000057562	ENSFCAP00000017278	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.427
CAT	GPX6	ENSFCAP00000057562	ENSFCAP00000054390	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.427
CAT	GPX8	ENSFCAP00000057562	ENSFCAP00000021520	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.542
CAT	GSR	ENSFCAP00000057562	ENSFCAP00000047168	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione-disulfide reductase.	0.583
CAT	GSS	ENSFCAP00000057562	ENSFCAP00000055199	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione synthetase.	0.518
CAT	GSTM4	ENSFCAP00000057562	ENSFCAP00000030513	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Glutathione S-transferase mu 4; Belongs to the GST superfamily.	0.626
CAT	GSTP1	ENSFCAP00000057562	ENSFCAP00000057548	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Uncharacterized protein; Belongs to the GST superfamily.	0.478
CAT	M3X280_FELCA	ENSFCAP00000057562	ENSFCAP00000020727	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	MsrB domain-containing protein.	0.502
CAT	MSRA	ENSFCAP00000057562	ENSFCAP00000011009	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Methionine sulfoxide reductase A.	0.551
CAT	MSRB3	ENSFCAP00000057562	ENSFCAP00000048488	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.	0.502
CAT	NME8	ENSFCAP00000057562	ENSFCAP00000011766	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	NME/NM23 family member 8.	0.480