(32 nodes) Glutathione metabolism network (Felis catus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GGT1	Uncharacterized protein. (568 aa)
	GGT7	Gamma-glutamyltransferase 7. (748 aa)
	MGST3	Microsomal glutathione S-transferase 3. (190 aa)
	LOC101096317	Uncharacterized protein; Belongs to the GST superfamily. (223 aa)
	GSTK1	Glutathione S-transferase kappa 1. (423 aa)
	GGCT	Uncharacterized protein. (188 aa)
	CHAC1	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (222 aa)
	GSTM3	Glutathione S-transferase. (226 aa)
	GPX5	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
	GSTO1	Glutathione S-transferase omega 1. (241 aa)
	LOC101083370	Uncharacterized protein. (257 aa)
	MGST2	Microsomal glutathione S-transferase 2. (146 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (643 aa)
	CHAC2	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (184 aa)
	LOC101084793	Uncharacterized protein. (222 aa)
	GPX4	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (196 aa)
	GGT5	Gamma-glutamyltransferase 5. (570 aa)
	GSTM4	Glutathione S-transferase mu 4; Belongs to the GST superfamily. (212 aa)
	LOC101083114	Uncharacterized protein; Belongs to the GST superfamily. (296 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (205 aa)
	PRDX6	Peroxiredoxin 6. (224 aa)
	EPHX1	Epoxide hydrolase 1. (565 aa)
	GSTA4	Glutathione S-transferase alpha 4. (222 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (553 aa)
	GCLM	Glutamate-cysteine ligase modifier subunit. (274 aa)
	GGT6	Gamma-glutamyltransferase 6. (586 aa)
	GPX6	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
	GSS	Glutathione synthetase. (525 aa)
	LAP3	Leucine aminopeptidase 3. (537 aa)
	OPLAH	5-oxoprolinase, ATP-hydrolysing. (1314 aa)
	GSTP1	Uncharacterized protein; Belongs to the GST superfamily. (438 aa)
	MGST1	Microsomal glutathione S-transferase 1. (176 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHAC1	CHAC2	ENSFCAP00000012044	ENSFCAP00000021377	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.903
CHAC1	GGCT	ENSFCAP00000012044	ENSFCAP00000008733	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein.	0.915
CHAC1	GGT1	ENSFCAP00000012044	ENSFCAP00000001405	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein.	0.908
CHAC1	GGT5	ENSFCAP00000012044	ENSFCAP00000023390	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Gamma-glutamyltransferase 5.	0.908
CHAC1	GGT6	ENSFCAP00000012044	ENSFCAP00000050448	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Gamma-glutamyltransferase 6.	0.912
CHAC1	GGT7	ENSFCAP00000012044	ENSFCAP00000002129	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Gamma-glutamyltransferase 7.	0.908
CHAC1	GPX1	ENSFCAP00000012044	ENSFCAP00000032344	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.901
CHAC1	GPX4	ENSFCAP00000012044	ENSFCAP00000022468	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.941
CHAC1	GPX5	ENSFCAP00000012044	ENSFCAP00000017278	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.901
CHAC1	GPX6	ENSFCAP00000012044	ENSFCAP00000054390	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.901
CHAC1	GSS	ENSFCAP00000012044	ENSFCAP00000055199	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione synthetase.	0.909
CHAC1	GSTA4	ENSFCAP00000012044	ENSFCAP00000035075	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione S-transferase alpha 4.	0.656
CHAC1	GSTK1	ENSFCAP00000012044	ENSFCAP00000006746	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione S-transferase kappa 1.	0.650
CHAC1	GSTM3	ENSFCAP00000012044	ENSFCAP00000014465	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione S-transferase.	0.650
CHAC1	GSTM4	ENSFCAP00000012044	ENSFCAP00000030513	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione S-transferase mu 4; Belongs to the GST superfamily.	0.664
CHAC1	GSTO1	ENSFCAP00000012044	ENSFCAP00000017784	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione S-transferase omega 1.	0.732
CHAC1	GSTP1	ENSFCAP00000012044	ENSFCAP00000057548	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein; Belongs to the GST superfamily.	0.655
CHAC1	LAP3	ENSFCAP00000012044	ENSFCAP00000057261	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Leucine aminopeptidase 3.	0.906
CHAC1	LOC101083114	ENSFCAP00000012044	ENSFCAP00000031212	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein; Belongs to the GST superfamily.	0.652
CHAC1	LOC101083370	ENSFCAP00000012044	ENSFCAP00000019481	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein.	0.652