37 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCDC57	Uncharacterized protein. (937 aa)
	ENSFCAP00000055340	Uncharacterized protein. (111 aa)
	FBXL8	F-box domain-containing protein. (374 aa)
	MTA3	Metastasis associated 1 family member 3. (594 aa)
	CDC25A	Cell division cycle 25A. (524 aa)
	KAT14	Lysine acetyltransferase 14. (782 aa)
	APP	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)
	FBXL15	F-box and leucine rich repeat protein 15. (378 aa)
	KDM8	Lysine demethylase 8. (414 aa)
	CDK14	Cyclin dependent kinase 14; Belongs to the protein kinase superfamily. (428 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (432 aa)
	FBXL3	F-box and leucine rich repeat protein 3. (428 aa)
	FOXM1	Forkhead box M1. (763 aa)
	CDC25C	Cell division cycle 25C. (477 aa)
	LATS1	Large tumor suppressor kinase 1. (1127 aa)
	CCNY	Cyclin Y; Belongs to the cyclin family. (341 aa)
	AFMID	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (306 aa)
	BIRC5	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa)
	FBXL7	F-box and leucine rich repeat protein 7. (491 aa)
	BACH1	BTB domain and CNC homolog 1. (748 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	FBXL12	F-box and leucine rich repeat protein 12. (348 aa)
	USH1C	USH1 protein network component harmonin. (899 aa)
	CHEK2	Checkpoint kinase 2. (569 aa)
	ENSA	Endosulfine alpha; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (130 aa)
	FBXL22	Uncharacterized protein. (228 aa)
	FBXL17	F-box and leucine rich repeat protein 17. (699 aa)
	TAF2	TATA-box binding protein associated factor 2. (1251 aa)
	PLK1	Serine/threonine-protein kinase PLK. (604 aa)
	MASTL	Microtubule associated serine/threonine kinase like. (882 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	CDC25B	Cell division cycle 25B. (578 aa)
	ENSFCAP00000060774	Protein kinase domain-containing protein. (78 aa)
	SKP2	S-phase kinase associated protein 2. (451 aa)
	FBXL6	F-box and leucine rich repeat protein 6. (537 aa)
	NES	Nestin; Belongs to the intermediate filament family. (1733 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BACH1	FBXL12	ENSFCAP00000041694	ENSFCAP00000042702	BTB domain and CNC homolog 1.	F-box and leucine rich repeat protein 12.	0.414
BACH1	FBXL15	ENSFCAP00000041694	ENSFCAP00000001155	BTB domain and CNC homolog 1.	F-box and leucine rich repeat protein 15.	0.414
BACH1	FBXL17	ENSFCAP00000041694	ENSFCAP00000048787	BTB domain and CNC homolog 1.	F-box and leucine rich repeat protein 17.	0.961
BACH1	FBXL6	ENSFCAP00000041694	ENSFCAP00000060104	BTB domain and CNC homolog 1.	F-box and leucine rich repeat protein 6.	0.414
BACH1	FBXL7	ENSFCAP00000041694	ENSFCAP00000040226	BTB domain and CNC homolog 1.	F-box and leucine rich repeat protein 7.	0.414
BIRC5	CCNA2	ENSFCAP00000038330	ENSFCAP00000019806	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	Cyclin A2; Belongs to the cyclin family.	0.914
BIRC5	CDC25C	ENSFCAP00000038330	ENSFCAP00000021232	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	Cell division cycle 25C.	0.492
BIRC5	CDK1	ENSFCAP00000038330	ENSFCAP00000013888	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.936
BIRC5	CDK14	ENSFCAP00000038330	ENSFCAP00000017585	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	Cyclin dependent kinase 14; Belongs to the protein kinase superfamily.	0.504
BIRC5	CHEK1	ENSFCAP00000038330	ENSFCAP00000014009	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.499
BIRC5	ENSFCAP00000060774	ENSFCAP00000038330	ENSFCAP00000060774	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	Protein kinase domain-containing protein.	0.936
BIRC5	FOXM1	ENSFCAP00000038330	ENSFCAP00000020505	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	Forkhead box M1.	0.879
BIRC5	PLK1	ENSFCAP00000038330	ENSFCAP00000012006	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	Serine/threonine-protein kinase PLK.	0.945
CCNA2	BIRC5	ENSFCAP00000019806	ENSFCAP00000038330	Cyclin A2; Belongs to the cyclin family.	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	0.914
CCNA2	CDC25A	ENSFCAP00000019806	ENSFCAP00000008147	Cyclin A2; Belongs to the cyclin family.	Cell division cycle 25A.	0.821
CCNA2	CDC25B	ENSFCAP00000019806	ENSFCAP00000061851	Cyclin A2; Belongs to the cyclin family.	Cell division cycle 25B.	0.849
CCNA2	CDC25C	ENSFCAP00000019806	ENSFCAP00000021232	Cyclin A2; Belongs to the cyclin family.	Cell division cycle 25C.	0.819
CCNA2	CDK1	ENSFCAP00000019806	ENSFCAP00000013888	Cyclin A2; Belongs to the cyclin family.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.999
CCNA2	CDK14	ENSFCAP00000019806	ENSFCAP00000017585	Cyclin A2; Belongs to the cyclin family.	Cyclin dependent kinase 14; Belongs to the protein kinase superfamily.	0.648
CCNA2	CHEK1	ENSFCAP00000019806	ENSFCAP00000014009	Cyclin A2; Belongs to the cyclin family.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.782