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| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa) |
| | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4. (1599 aa) |
| | BRAP | BRCA1 associated protein. (592 aa) |
| | LRRK2 | Leucine rich repeat kinase 2. (2527 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | POU4F2 | POU domain protein. (408 aa) |
| | PEA15 | DED domain-containing protein. (130 aa) |
| | DAXX | Death domain associated protein. (748 aa) |
| | SMAD1 | Mothers against decapentaplegic homolog. (465 aa) |
| | RHBDD3 | Rhomboid domain containing 3. (393 aa) |
| | NF2 | Neurofibromin 2. (596 aa) |
| | PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (615 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (467 aa) |
| | TRIB1 | Tribbles pseudokinase 1. (372 aa) |
| | ABL1 | Tyrosine-protein kinase. (1150 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | SORBS3 | Sorbin and SH3 domain containing 3. (676 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | TNFSF11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa) |
| | IQGAP3 | IQ motif containing GTPase activating protein 3. (1630 aa) |
| | NOX1 | NADPH oxidase 1. (564 aa) |
| | NLK | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa) |
| | SPRY2 | Sprouty RTK signaling antagonist 2. (315 aa) |
| | MAP3K6 | Mitogen-activated protein kinase kinase kinase 6. (1307 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1366 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1014 aa) |
| | HACD3 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (362 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (804 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa) |
| | MAPK4 | Mitogen-activated protein kinase 4. (583 aa) |
| | MAP3K10 | Mitogen-activated protein kinase kinase kinase. (937 aa) |
| | MAP4K2 | Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (820 aa) |
| | GRB10 | Growth factor receptor bound protein 10. (594 aa) |
| | MAP3K12 | Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (892 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (804 aa) |
| | MAP3K15 | Mitogen-activated protein kinase kinase kinase 15. (275 aa) |
| | RET | Ret proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1138 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2. (409 aa) |
| | SPRY1 | Sprouty RTK signaling antagonist 1. (362 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (954 aa) |
| | MAP2K2 | Protein kinase domain-containing protein. (549 aa) |
| | PBK | PDZ binding kinase. (337 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | EDN1 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa) |
| | DUSP10 | Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (477 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | MAP4K5 | Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (845 aa) |
| | NPHS1 | NPHS1 adhesion molecule, nephrin. (1241 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | HTR2B | 5-hydroxytryptamine receptor 2B. (503 aa) |
| | SCG2 | Secretogranin II. (680 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | TLR8 | Toll-like receptor 8; Belongs to the Toll-like receptor family. (1039 aa) |
| | MAP3K11 | Mitogen-activated protein kinase kinase kinase. (865 aa) |
| | ITPKB | Kinase; Belongs to the inositol phosphokinase (IPK) family. (933 aa) |
| | ANKRD37 | Ankyrin repeat domain 37. (158 aa) |
| | ADRA2B | Adrenoceptor alpha 2B. (444 aa) |
| | TAOK3 | TAO kinase 3. (914 aa) |
| | PPM1L | Protein phosphatase, Mg2+/Mn2+ dependent 1L. (360 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | HESX1 | HESX homeobox 1. (207 aa) |
| | TMEM248 | Transmembrane protein 248. (354 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa) |
| | MEF2A | Myocyte enhancer factor 2A. (542 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (338 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1484 aa) |
| | ANKRD10 | Ankyrin repeat domain 10. (420 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | STRADB | STE20 related adaptor beta. (415 aa) |
| | PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa) |
| | MAP3K9 | Mitogen-activated protein kinase kinase kinase. (1102 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa) |
| | AVP | Arginine vasopressin; Belongs to the vasopressin/oxytocin family. (166 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4. (1318 aa) |
| | KARS1 | Lysine--tRNA ligase. (625 aa) |
| | CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa) |
| | MEF2C | MADS-box domain-containing protein. (483 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (732 aa) |
| | SETX | Senataxin. (2669 aa) |
| | TNIK | TRAF2 and NCK interacting kinase. (1457 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa) |
| | HSF1 | Heat shock transcription factor 1. (527 aa) |
| | MAP3K21 | Mitogen-activated protein kinase kinase kinase. (1041 aa) |
| | ENSFCAP00000033453 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (228 aa) |
| | LOC100302540 | C-C motif chemokine. (93 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (457 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | ASH1L | ASH1 like histone lysine methyltransferase. (2965 aa) |
| | RAPGEF1 | Rap guanine nucleotide exchange factor 1. (1270 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | TLR7 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (1071 aa) |
| | IGFBP4 | Insulin like growth factor binding protein 4. (258 aa) |
| | EPGN | Epithelial mitogen. (153 aa) |
| | MAPK6 | Mitogen-activated protein kinase 6. (722 aa) |
| | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (916 aa) |
| | CDC42EP5 | CDC42 effector protein 5. (153 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (659 aa) |
| | FLCN | Uncharacterized protein. (579 aa) |
| | NENF | Neudesin neurotrophic factor; Belongs to the cytochrome b5 family. (174 aa) |
| | C1QL4 | Complement C1q like 4. (238 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (805 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa) |
| | ZFP36L2 | ZFP36 ring finger protein like 2. (705 aa) |
| | SOX9 | SRY-box transcription factor 9. (511 aa) |
| | MAP3K20 | Uncharacterized protein. (800 aa) |
| | MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (820 aa) |
| | IGFBP3 | Insulin like growth factor binding protein 3. (299 aa) |
| | ZFP36 | ZFP36 ring finger protein. (513 aa) |
| | PAK3 | P21 (RAC1) activated kinase 3. (589 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa) |
| | MAPK8IP1 | Mitogen-activated protein kinase 8 interacting protein 1. (703 aa) |
| | DAXX-2 | Daxx domain-containing protein. (769 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | MAP2K5 | Uncharacterized protein; Belongs to the protein kinase superfamily. (448 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa) |
| | MAP3K13 | Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (1021 aa) |
| | ANKRD26 | ANK_REP_REGION domain-containing protein. (266 aa) |
| | CCR5 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | NF1 | Neurofibromin 1. (2856 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1299 aa) |
| | BANK1 | B cell scaffold protein with ankyrin repeats 1. (779 aa) |
| | CTSH | Cathepsin H; Belongs to the peptidase C1 family. (572 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (383 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (550 aa) |
| | MAPK8IP2 | Mitogen-activated protein kinase 8 interacting protein 2. (834 aa) |
| | STK3 | Serine/threonine kinase 3. (573 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (402 aa) |
| | WNK4 | WNK lysine deficient protein kinase 4. (1322 aa) |
