STRINGSTRING
FBXO7 FBXO7 RB1CC1 RB1CC1 ULK1 ULK1 ATG9A ATG9A ATG2A ATG2A FBXL4 FBXL4 PINK1 PINK1 GBA GBA WDR45B WDR45B BECN1 BECN1 ATG9B ATG9B AMBRA1 AMBRA1 ATG13 ATG13 SQSTM1 SQSTM1 ATG14 ATG14 FUNDC2 FUNDC2 PHB2 PHB2 GABARAP GABARAP CISD2 CISD2 MAP1LC3A MAP1LC3A FUNDC1 FUNDC1 OGT OGT ENSFCAP00000031232 ENSFCAP00000031232 ENSFCAP00000033718 ENSFCAP00000033718 LOC101095070 LOC101095070 PRAF2 PRAF2 ATG7 ATG7 ARFIP2 ARFIP2 FIS1 FIS1 MAP1LC3C MAP1LC3C ENSFCAP00000041779 ENSFCAP00000041779 SPATA33 SPATA33 PRKN PRKN ENSFCAP00000044926 ENSFCAP00000044926 TP53 TP53 ATG3 ATG3 ATG5 ATG5 GABARAPL1 GABARAPL1 TIGAR TIGAR MAP1LC3B MAP1LC3B SNX7 SNX7 WIPI2 WIPI2 ATG4D ATG4D SPATA18 SPATA18 WIPI1 WIPI1 ATG4B ATG4B ENSFCAP00000060319 ENSFCAP00000060319 ATG2B ATG2B SNX30 SNX30 ATG12 ATG12 USP30 USP30 GABARAPL2 GABARAPL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FBXO7F-box protein 7. (444 aa)
RB1CC1RB1 inducible coiled-coil 1. (1593 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1113 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (998 aa)
ATG2AAutophagy related 2A. (1928 aa)
FBXL4F-box and leucine rich repeat protein 4. (621 aa)
PINK1PTEN induced kinase 1. (581 aa)
GBAGlucosylceramidase. (536 aa)
WDR45BWD repeat domain 45B. (344 aa)
BECN1Beclin 1. (448 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (920 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1301 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
SQSTM1Sequestosome 1. (443 aa)
ATG14Autophagy related 14. (510 aa)
FUNDC2FUN14 domain containing 2. (190 aa)
PHB2Prohibitin. (299 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
CISD2CDGSH iron sulfur domain 2. (135 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
FUNDC1Uncharacterized protein. (155 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
ENSFCAP00000031232Uncharacterized protein. (108 aa)
ENSFCAP00000033718ZnF_CDGSH domain-containing protein. (99 aa)
LOC101095070Uncharacterized protein. (141 aa)
PRAF2WD repeat domain 45. (361 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (752 aa)
ARFIP2ADP ribosylation factor interacting protein 2. (374 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
MAP1LC3CUncharacterized protein. (141 aa)
ENSFCAP00000041779Uncharacterized protein. (112 aa)
SPATA33Uncharacterized protein. (96 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (462 aa)
ENSFCAP00000044926Uncharacterized protein. (107 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
ATG3Autophagy-related protein 3. (333 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
GABARAPL1GABA type A receptor associated protein like 1. (151 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (428 aa)
MAP1LC3BUncharacterized protein. (309 aa)
SNX7Sorting nexin 7. (513 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (468 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (475 aa)
SPATA18Spermatogenesis associated 18. (540 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (470 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (578 aa)
ENSFCAP00000060319Uncharacterized protein. (108 aa)
ATG2BAutophagy related 2B. (2114 aa)
SNX30Sorting nexin family member 30. (449 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (519 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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