52 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	HAS2	Hyaluronan synthase 2. (552 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
	DDX17	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (729 aa)
	TASOR	Transcription activation suppressor. (1665 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa)
	RTN4	Reticulon. (1190 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	NOTCH1	Notch receptor 1. (2543 aa)
	SNAI2	Uncharacterized protein. (268 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
	LOXL2	Lysyl oxidase like 2. (773 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (828 aa)
	KBTBD8	Kelch repeat and BTB domain containing 8. (601 aa)
	SNAI1	Snail family transcriptional repressor 1. (264 aa)
	CUL7	Cullin 7; Belongs to the cullin family. (1695 aa)
	LOXL3	Lysyl oxidase like 3. (974 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (825 aa)
	ENG	Endoglin. (654 aa)
	TMEM100	Transmembrane protein 100. (134 aa)
	AKNA	AT-hook transcription factor. (1405 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	TRIM28	Tripartite motif containing 28. (821 aa)
	KLHL12	Kelch like family member 12. (838 aa)
	EFNA1	Ephrin A1; Belongs to the ephrin family. (357 aa)
	TCOF1	Treacle ribosome biogenesis factor 1. (1407 aa)
	ENSFCAP00000057918	Uncharacterized protein. (293 aa)
	ENSFCAP00000057780	Uncharacterized protein. (585 aa)
	PEF1	Penta-EF-hand domain containing 1. (297 aa)
	ADAM15	ADAM metallopeptidase domain 15. (869 aa)
	GSC	Goosecoid homeobox. (256 aa)
	TBX3	T-box transcription factor 3. (745 aa)
	MSX1	Msh homeobox 1. (303 aa)
	LEF1	Lymphoid enhancer binding factor 1. (415 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	SOX9	SRY-box transcription factor 9. (511 aa)
	GSK3B	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
	TGFBR3L	ZP domain-containing protein. (485 aa)
	HMGA2	Uncharacterized protein. (109 aa)
	PDCD6	Programmed cell death 6. (189 aa)
	RFLNB	Refilin B. (218 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	FLNA	Filamin A. (2808 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1921 aa)
	CNRIP1	Uncharacterized protein. (324 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	NOG	ENSFCAP00000031036	ENSFCAP00000046242	Bone morphogenetic protein 2.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.993
BMP2	SMAD4	ENSFCAP00000031036	ENSFCAP00000031311	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.846
BMP2	SOX9	ENSFCAP00000031036	ENSFCAP00000045943	Bone morphogenetic protein 2.	SRY-box transcription factor 9.	0.569
BMP2	TGFB1	ENSFCAP00000031036	ENSFCAP00000005040	Bone morphogenetic protein 2.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.455
BMP2	TGFBR1	ENSFCAP00000031036	ENSFCAP00000047904	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.702
CNRIP1	GSK3B	ENSFCAP00000036384	ENSFCAP00000043679	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.916
CUL7	KLHL12	ENSFCAP00000009011	ENSFCAP00000059513	Cullin 7; Belongs to the cullin family.	Kelch like family member 12.	0.461
DDX17	DDX5	ENSFCAP00000027708	ENSFCAP00000003241	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.827
DDX5	DDX17	ENSFCAP00000003241	ENSFCAP00000027708	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.827
EDN1	EDNRA	ENSFCAP00000013767	ENSFCAP00000040752	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.999
EDN1	ENG	ENSFCAP00000013767	ENSFCAP00000001383	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endoglin.	0.543
EDN1	HIF1A	ENSFCAP00000013767	ENSFCAP00000003163	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Hypoxia inducible factor 1 subunit alpha.	0.538
EDN1	TGFB1	ENSFCAP00000013767	ENSFCAP00000005040	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.534
EDNRA	EDN1	ENSFCAP00000040752	ENSFCAP00000013767	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.999
ENG	EDN1	ENSFCAP00000001383	ENSFCAP00000013767	Endoglin.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.543
ENG	TGFB1	ENSFCAP00000001383	ENSFCAP00000005040	Endoglin.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.799
ENG	TGFB2	ENSFCAP00000001383	ENSFCAP00000032705	Endoglin.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.491
ENG	TGFBR1	ENSFCAP00000001383	ENSFCAP00000047904	Endoglin.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.690
FLNA	HIF1A	ENSFCAP00000039439	ENSFCAP00000003163	Filamin A.	Hypoxia inducible factor 1 subunit alpha.	0.610
GSK3B	CNRIP1	ENSFCAP00000043679	ENSFCAP00000036384	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.916