STRINGSTRING
DNMT3L DNMT3L MAP3K4 MAP3K4 TRIM28 TRIM28 ETV2 ETV2 STK3 STK3 ETNK2 ETNK2 ENSFCAP00000059874 ENSFCAP00000059874 PRDX3 PRDX3 PKD1 PKD1 ADA ADA ST14 ST14 BPTF BPTF FBXW8 FBXW8 CCDC134 CCDC134 HSD17B2 HSD17B2 STOX2 STOX2 HES1 HES1 HS6ST1 HS6ST1 LOC101093046 LOC101093046 DLX3 DLX3 MDFI MDFI CEBPB CEBPB ENSFCAP00000049367 ENSFCAP00000049367 ENSFCAP00000048958 ENSFCAP00000048958 LEF1 LEF1 PLK4 PLK4 ZFP36L1 ZFP36L1 RTCB RTCB MAPK1 MAPK1 PKD2 PKD2 FOSL1 FOSL1 PPARD PPARD LOC101092829 LOC101092829 ZFAT ZFAT WNT2 WNT2 ALKBH1 ALKBH1 APELA APELA DAZAP1 DAZAP1 LEP LEP ENSFCAP00000033605 ENSFCAP00000033605 IGF2 IGF2 LHX4 LHX4 LIF LIF SETD2 SETD2 ASH1L ASH1L ARNT ARNT NSDHL NSDHL GGNBP2 GGNBP2 GCM1 GCM1 PRDM1 PRDM1 ENSFCAP00000042577 ENSFCAP00000042577 VASH1 VASH1 HECTD1 HECTD1 CDKN1C CDKN1C LHX3 LHX3 LOC111559138 LOC111559138 MED1 MED1 CDKN1B CDKN1B ENSFCAP00000046520 ENSFCAP00000046520 ENSFCAP00000046014 ENSFCAP00000046014 PHLDA2 PHLDA2 ENSFCAP00000044777 ENSFCAP00000044777 GRB2 GRB2 CITED2 CITED2 SPINT2 SPINT2 PTN PTN VDR VDR VASH2 VASH2 DEDD DEDD SOCS3 SOCS3 STK4 STK4 CCN1 CCN1 LDOC1 LDOC1 SP3 SP3 JUNB JUNB PDGFB PDGFB TAF10 TAF10 HAND1 HAND1 CYP27B1 CYP27B1 BMPR2 BMPR2 GJB5 GJB5 EPAS1 EPAS1 CYP27C1 CYP27C1 IL10 IL10 GHSR GHSR GHRL GHRL E2F7 E2F7 E2F8 E2F8 SNAI1 SNAI1 ADAM19 ADAM19 CUL7 CUL7 NOTCH2 NOTCH2 HNF1A HNF1A SOX15 SOX15 PCDH12 PCDH12 TPPP3 TPPP3 RSPO3 RSPO3 BIRC6 BIRC6 PLCD3 PLCD3 CSF2 CSF2 HIF1A HIF1A KRT19 KRT19 NODAL NODAL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DNMT3LUncharacterized protein. (157 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1599 aa)
TRIM28Tripartite motif containing 28. (821 aa)
ETV2ETS variant 2. (249 aa)
STK3Serine/threonine kinase 3. (573 aa)
ETNK2Ethanolamine kinase 2. (425 aa)
ENSFCAP00000059874IF rod domain-containing protein; Belongs to the intermediate filament family. (136 aa)
PRDX3Peroxiredoxin 3. (270 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4299 aa)
ADAAdenosine deaminase. (431 aa)
ST14Suppression of tumorigenicity 14. (861 aa)
BPTFBromodomain PHD finger transcription factor. (3166 aa)
FBXW8F-box and WD repeat domain containing 8. (701 aa)
CCDC134Coiled-coil domain containing 134. (230 aa)
HSD17B2Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (387 aa)
STOX2Storkhead box 2. (926 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
LOC101093046Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (208 aa)
DLX3Distal-less homeobox 3. (287 aa)
MDFIMyoD family inhibitor. (246 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
ENSFCAP00000049367annotation not available (113 aa)
ENSFCAP00000048958BHLH domain-containing protein. (109 aa)
LEF1Lymphoid enhancer binding factor 1. (415 aa)
PLK4Polo like kinase 4. (969 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
RTCBRNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. (505 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (273 aa)
PPARDPeroxisome proliferator activated receptor delta. (464 aa)
LOC101092829Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (165 aa)
ZFATZinc finger and AT-hook domain containing. (1247 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (352 aa)
APELAUncharacterized protein. (54 aa)
DAZAP1DAZ associated protein 1. (406 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
ENSFCAP00000033605Uncharacterized protein. (147 aa)
IGF2Insulin like growth factor 2. (280 aa)
LHX4LIM homeobox 4. (390 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2563 aa)
ASH1LASH1 like histone lysine methyltransferase. (2965 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (790 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (361 aa)
GGNBP2Gametogenetin binding protein 2. (740 aa)
GCM1Glial cells missing transcription factor 1. (435 aa)
PRDM1PR/SET domain 1. (821 aa)
ENSFCAP00000042577DUF4939 domain-containing protein. (113 aa)
VASH1Vasohibin 1. (446 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (264 aa)
LHX3LIM homeobox 3. (403 aa)
LOC111559138IF rod domain-containing protein; Belongs to the intermediate filament family. (388 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
ENSFCAP00000046520IF rod domain-containing protein; Belongs to the intermediate filament family. (148 aa)
ENSFCAP00000046014Uncharacterized protein. (143 aa)
PHLDA2Pleckstrin homology like domain family A member 2. (131 aa)
ENSFCAP00000044777Uncharacterized protein. (321 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
SPINT2Serine peptidase inhibitor, Kunitz type 2. (252 aa)
PTNPleiotrophin. (179 aa)
VDRVitamin D receptor. (441 aa)
VASH2Vasohibin 2. (355 aa)
DEDDDeath effector domain containing. (318 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
STK4Serine/threonine kinase 4. (487 aa)
CCN1Cellular communication network factor 1. (382 aa)
LDOC1LDOC1 regulator of NFKB signaling. (146 aa)
SP3Sp3 transcription factor. (713 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
GJB5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (273 aa)
EPAS1Endothelial PAS domain protein 1. (872 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (580 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
GHRLAppetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (117 aa)
E2F7E2F transcription factor 7. (910 aa)
E2F8E2F transcription factor 8. (864 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
ADAM19ADAM metallopeptidase domain 19. (909 aa)
CUL7Cullin 7; Belongs to the cullin family. (1695 aa)
NOTCH2Notch receptor 2. (2493 aa)
HNF1AHNF1 homeobox A. (639 aa)
SOX15SRY-box 15. (233 aa)
PCDH12Protocadherin 12. (1208 aa)
TPPP3Tubulin polymerization promoting protein family member 3. (176 aa)
RSPO3R-spondin 3. (279 aa)
BIRC6Baculoviral IAP repeat containing 6. (4862 aa)
PLCD3Phosphoinositide phospholipase C. (777 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (142 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
KRT19IF rod domain-containing protein; Belongs to the intermediate filament family. (399 aa)
NODALNodal growth differentiation factor. (348 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.