STRINGSTRING
EMC10 EMC10 FLT4 FLT4 PDPK1 PDPK1 STAT3 STAT3 VIP VIP HRAS HRAS AKT3 AKT3 THBS4 THBS4 CDH13 CDH13 AKT1 AKT1 EGR3 EGR3 VEGFB VEGFB VEGFC VEGFC KDR KDR PRKD2 PRKD2 ITGA4 ITGA4 IL12A IL12A GHRL GHRL THBS1 THBS1 PRKCA PRKCA F3 F3 AIMP1 AIMP1 ALOX5 ALOX5 IL10 IL10 BMPR2 BMPR2 DLL4 DLL4 PRL PRL TIE1 TIE1 PDGFB PDGFB AGGF1 AGGF1 SP1 SP1 PROX1 PROX1 HTR2B HTR2B ECM1 ECM1 SCG2 SCG2 KRIT1 KRIT1 FGF7 FGF7 CAV2 CAV2 CCL24 CCL24 FUT2 FUT2 ATP5F1A ATP5F1A JUN JUN VASH2 VASH2 PDCD10 PDCD10 PIK3CD PIK3CD BMP6 BMP6 IL12B IL12B PRKD1 PRKD1 SULF1 SULF1 FLT1 FLT1 SIRT1 SIRT1 CAV1 CAV1 APELA APELA MEF2C MEF2C BMP2 BMP2 NRARP NRARP JCAD JCAD FGF10 FGF10 LEP LEP ITGB3 ITGB3 NRAS NRAS EGFL7 EGFL7 TBC1D31 TBC1D31 ACVRL1 ACVRL1 MYDGF MYDGF LRG1 LRG1 PDCD6 PDCD6 FUT1 FUT1 ALDH1A2 ALDH1A2 TNMD TNMD CCL26 CCL26 VASH1 VASH1 NGFR NGFR PGF PGF ENSFCAP00000046014 ENSFCAP00000046014 PDCL3 PDCL3 TGFBR1 TGFBR1 SYNJ2BP SYNJ2BP SIRT6 SIRT6 VEGFA VEGFA STAT1 STAT1 TNF TNF BMP4 BMP4 PROK1 PROK1 FGFBP1 FGFBP1 ATOH8 ATOH8 STAT5A STAT5A NF1 NF1 CNMD CNMD MMRN2 MMRN2 HMGB1 HMGB1 APOH APOH RNASE4 RNASE4 AKT2 AKT2 HMOX1 HMOX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EMC10ER membrane protein complex subunit 10. (262 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1405 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
VIPVasoactive intestinal peptide. (170 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
THBS4Thrombospondin 4. (964 aa)
CDH13Cadherin 13. (713 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
EGR3Early growth response 3. (392 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (885 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1036 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
GHRLAppetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (117 aa)
THBS1Thrombospondin 1. (1170 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
F3Coagulation factor III, tissue factor. (379 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (336 aa)
ALOX5Arachidonate 5-lipoxygenase. (745 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (229 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1137 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
AGGF1Uncharacterized protein. (713 aa)
SP1Sp1 transcription factor. (786 aa)
PROX1Prospero homeobox 1. (737 aa)
HTR2B5-hydroxytryptamine receptor 2B. (503 aa)
ECM1Extracellular matrix protein 1. (562 aa)
SCG2Secretogranin II. (680 aa)
KRIT1KRIT1 ankyrin repeat containing. (736 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (262 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
FUT2L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (331 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
VASH2Vasohibin 2. (355 aa)
PDCD10Programmed cell death 10. (212 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BMP6Bone morphogenetic protein 6. (502 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (930 aa)
SULF1Sulfatase 1. (1116 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
SIRT1Sirtuin 1. (745 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
APELAUncharacterized protein. (54 aa)
MEF2CMADS-box domain-containing protein. (483 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
JCADJunctional cadherin 5 associated. (1354 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
EGFL7EGF like domain multiple 7. (274 aa)
TBC1D31TBC1 domain family member 31. (1066 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
MYDGFMyeloid derived growth factor. (173 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (346 aa)
PDCD6Programmed cell death 6. (189 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (491 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (549 aa)
TNMDTenomodulin. (317 aa)
CCL26C-C motif chemokine. (94 aa)
VASH1Vasohibin 1. (446 aa)
NGFRNerve growth factor receptor. (421 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
ENSFCAP00000046014Uncharacterized protein. (143 aa)
PDCL3Phosducin like 3. (240 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
SIRT6Sirtuin 6. (412 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (450 aa)
STAT1Signal transducer and activator of transcription. (885 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
PROK1Prokineticin 1. (154 aa)
FGFBP1Fibroblast growth factor binding protein 1. (224 aa)
ATOH8Atonal bHLH transcription factor 8. (355 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
NF1Neurofibromin 1. (2856 aa)
CNMDChondromodulin. (500 aa)
MMRN2Multimerin 2. (1005 aa)
HMGB1Uncharacterized protein. (233 aa)
APOHApolipoprotein H. (382 aa)
RNASE4Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (189 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
HMOX1Heme oxygenase 1. (404 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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