STRINGSTRING
NRARP NRARP EMC10 EMC10 FLT4 FLT4 PDPK1 PDPK1 STAT3 STAT3 VIP VIP HRAS HRAS AKT3 AKT3 THBS4 THBS4 CDH13 CDH13 AKT1 AKT1 EGR3 EGR3 VEGFB VEGFB VEGFC VEGFC KDR KDR PRKD2 PRKD2 ITGA4 ITGA4 PRKCA PRKCA F3 F3 IL10 IL10 BMPR2 BMPR2 PDGFB PDGFB AGGF1 AGGF1 SP1 SP1 PROX1 PROX1 HTR2B HTR2B ECM1 ECM1 SCG2 SCG2 FGF7 FGF7 CCL24 CCL24 JUN JUN VASH2 VASH2 PIK3CD PIK3CD BMP6 BMP6 PRKD1 PRKD1 SIRT1 SIRT1 APELA APELA BMP2 BMP2 JCAD JCAD FGF10 FGF10 ITGB3 ITGB3 NRAS NRAS EGFL7 EGFL7 ACVRL1 ACVRL1 MYDGF MYDGF LRG1 LRG1 PDCD6 PDCD6 CCL26 CCL26 PGF PGF ENSFCAP00000046014 ENSFCAP00000046014 PDCL3 PDCL3 TGFBR1 TGFBR1 SIRT6 SIRT6 VEGFA VEGFA BMP4 BMP4 PROK1 PROK1 FGFBP1 FGFBP1 STAT5A STAT5A NF1 NF1 HMGB1 HMGB1 RNASE4 RNASE4 AKT2 AKT2 HMOX1 HMOX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
EMC10ER membrane protein complex subunit 10. (262 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1405 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
VIPVasoactive intestinal peptide. (170 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
THBS4Thrombospondin 4. (964 aa)
CDH13Cadherin 13. (713 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
EGR3Early growth response 3. (392 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (885 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1036 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
F3Coagulation factor III, tissue factor. (379 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
AGGF1Uncharacterized protein. (713 aa)
SP1Sp1 transcription factor. (786 aa)
PROX1Prospero homeobox 1. (737 aa)
HTR2B5-hydroxytryptamine receptor 2B. (503 aa)
ECM1Extracellular matrix protein 1. (562 aa)
SCG2Secretogranin II. (680 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
VASH2Vasohibin 2. (355 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BMP6Bone morphogenetic protein 6. (502 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (930 aa)
SIRT1Sirtuin 1. (745 aa)
APELAUncharacterized protein. (54 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
JCADJunctional cadherin 5 associated. (1354 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
EGFL7EGF like domain multiple 7. (274 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
MYDGFMyeloid derived growth factor. (173 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (346 aa)
PDCD6Programmed cell death 6. (189 aa)
CCL26C-C motif chemokine. (94 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
ENSFCAP00000046014Uncharacterized protein. (143 aa)
PDCL3Phosducin like 3. (240 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
SIRT6Sirtuin 6. (412 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (450 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
PROK1Prokineticin 1. (154 aa)
FGFBP1Fibroblast growth factor binding protein 1. (224 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
NF1Neurofibromin 1. (2856 aa)
HMGB1Uncharacterized protein. (233 aa)
RNASE4Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (189 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
HMOX1Heme oxygenase 1. (404 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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