54 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KRT25	Keratin 25; Belongs to the intermediate filament family. (450 aa)
	TRPC4AP	Transient receptor potential cation channel subfamily C member 4 associated protein. (797 aa)
	ERCC2	ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
	INTU	Inturned planar cell polarity protein. (890 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (795 aa)
	CELSR1	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3085 aa)
	NF1	Neurofibromin 1. (2856 aa)
	PLA2G10	Phospholipase A(2). (162 aa)
	DLX3	Distal-less homeobox 3. (287 aa)
	EDAR	Ectodysplasin A receptor. (447 aa)
	GORAB	Golgin, RAB6 interacting. (395 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (555 aa)
	SOX9	SRY-box transcription factor 9. (511 aa)
	INHBA	Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa)
	NGFR	Nerve growth factor receptor. (421 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (388 aa)
	HOXC13	Homeobox C13. (329 aa)
	LDB1	LIM domain binding 1. (411 aa)
	SOX18	SRY-box transcription factor 18. (465 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
	SOSTDC1	Sclerostin domain containing 1. (206 aa)
	LRP4	LDL receptor related protein 4. (1905 aa)
	NSDHL	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (361 aa)
	FST	Follistatin. (423 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	SAV1	Salvador family WW domain containing protein 1. (395 aa)
	NSUN2	NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (912 aa)
	FOXQ1	Forkhead box Q1. (406 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
	ALX4	ALX homeobox 4. (410 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	LHX2	LIM homeobox 2. (406 aa)
	LGR5	Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
	FOXN1	Forkhead box N1. (646 aa)
	TNFRSF19	TNF receptor superfamily member 19. (455 aa)
	LDB2	LIM domain binding 2. (373 aa)
	SNAI1	Snail family transcriptional repressor 1. (264 aa)
	TMEM79	Transmembrane protein 79. (394 aa)
	PIAS4	Protein inhibitor of activated STAT 4. (514 aa)
	NOM1	Nucleolar protein with MIF4G domain 1. (919 aa)
	PUM2	Pumilio RNA binding family member 2. (1063 aa)
	DSG4	Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1040 aa)
	APCDD1	APC down-regulated 1. (765 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	NOTCH1	Notch receptor 1. (2543 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	ACVR1B	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	KRT26	Keratin 26; Belongs to the intermediate filament family. (465 aa)
	CD109	CD109 molecule. (1446 aa)
	ZDHHC21	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (299 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1B	FST	ENSFCAP00000022169	ENSFCAP00000034133	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Follistatin.	0.573
ACVR1B	INHBA	ENSFCAP00000022169	ENSFCAP00000045665	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity).	0.995
ACVR1B	TGFB2	ENSFCAP00000022169	ENSFCAP00000032705	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.460
APCDD1	DSG4	ENSFCAP00000018398	ENSFCAP00000017616	APC down-regulated 1.	Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.665
APCDD1	KRT26	ENSFCAP00000018398	ENSFCAP00000022778	APC down-regulated 1.	Keratin 26; Belongs to the intermediate filament family.	0.469
CELSR1	FZD3	ENSFCAP00000057417	ENSFCAP00000021872	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.780
CELSR1	SMO	ENSFCAP00000057417	ENSFCAP00000059936	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.413
DLX3	FOXN1	ENSFCAP00000049676	ENSFCAP00000007665	Distal-less homeobox 3.	Forkhead box N1.	0.744
DLX3	LHX2	ENSFCAP00000049676	ENSFCAP00000006397	Distal-less homeobox 3.	LIM homeobox 2.	0.605
DSG4	APCDD1	ENSFCAP00000017616	ENSFCAP00000018398	Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	APC down-regulated 1.	0.665
DSG4	FOXN1	ENSFCAP00000017616	ENSFCAP00000007665	Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Forkhead box N1.	0.417
DSG4	HOXC13	ENSFCAP00000017616	ENSFCAP00000043841	Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Homeobox C13.	0.483
DSG4	KRT25	ENSFCAP00000017616	ENSFCAP00000001866	Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Keratin 25; Belongs to the intermediate filament family.	0.555
EDA	EDAR	ENSFCAP00000043977	ENSFCAP00000049365	Ectodysplasin A; Belongs to the tumor necrosis factor family.	Ectodysplasin A receptor.	0.995
EDAR	EDA	ENSFCAP00000049365	ENSFCAP00000043977	Ectodysplasin A receptor.	Ectodysplasin A; Belongs to the tumor necrosis factor family.	0.995
EDAR	WNT10A	ENSFCAP00000049365	ENSFCAP00000040293	Ectodysplasin A receptor.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.673
ERCC2	NSDHL	ENSFCAP00000002466	ENSFCAP00000038349	ERCC excision repair 2, TFIIH core complex helicase subunit.	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family.	0.419
FGF10	FGF7	ENSFCAP00000032796	ENSFCAP00000018919	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.436
FGF10	FST	ENSFCAP00000032796	ENSFCAP00000034133	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Follistatin.	0.498
FGF10	LGR5	ENSFCAP00000032796	ENSFCAP00000007472	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Leucine rich repeat containing G protein-coupled receptor 5.	0.429