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HOXA3 HOXA3 EDNRA EDNRA FLNA FLNA ACVRL1 ACVRL1 CBS CBS JAG1 JAG1 ATG5 ATG5 SEMA3C SEMA3C EXT1 EXT1 BAK1 BAK1 MDM2 MDM2 NOL3 NOL3 MEF2C MEF2C AXL AXL FGF10 FGF10 LIF LIF CRB1 CRB1 CHD7 CHD7 RSPO3 RSPO3 EPAS1 EPAS1 BMPR2 BMPR2 DLL4 DLL4 CCR2 CCR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HOXA3Homeobox A3. (441 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
FLNAFilamin A. (2808 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (633 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1287 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (749 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
BAK1BCL2 antagonist/killer 1. (251 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
NOL3Nucleolar protein 3. (218 aa)
MEF2CMADS-box domain-containing protein. (483 aa)
AXLAXL receptor tyrosine kinase. (861 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
CRB1Crumbs cell polarity complex component 1. (1405 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2995 aa)
RSPO3R-spondin 3. (279 aa)
EPAS1Endothelial PAS domain protein 1. (872 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
CCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (328 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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