44 items (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANXA3	Annexin. (457 aa)
	VAMP7	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
	DNASE1L3	Deoxyribonuclease; Belongs to the DNase I family. (311 aa)
	HAVCR2	Hepatitis A virus cellular receptor 2. (280 aa)
	KARS1	Lysine--tRNA ligase. (625 aa)
	RABGEF1	Uncharacterized protein. (491 aa)
	LOC100302540	C-C motif chemokine. (93 aa)
	PRKCE	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
	DYSF	Dysferlin. (2112 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
	CPLX2	Complexin 2. (134 aa)
	FCER1G	Fc fragment of IgE receptor Ig. (86 aa)
	GRP	Uncharacterized protein. (265 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa)
	PTGDR	Prostaglandin D2 receptor. (358 aa)
	PLA2G3	Phospholipase A2 group III. (522 aa)
	S100A13	S100 calcium binding protein A13; Belongs to the S-100 family. (98 aa)
	CLNK	Cytokine dependent hematopoietic cell linker. (426 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	TYROBP	TYRO protein tyrosine kinase binding protein. (137 aa)
	RASGRP1	RAS guanyl releasing protein 1. (877 aa)
	CHGA	Chromogranin A. (566 aa)
	DNASE1L2	Deoxyribonuclease 1 like 2. (356 aa)
	SBNO2	Strawberry notch homolog 2. (1352 aa)
	VAMP2	V-SNARE coiled-coil homology domain-containing protein. (170 aa)
	SNAP23	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (257 aa)
	TREX1	Three prime repair exonuclease 1. (314 aa)
	RAB44	RAB44, member RAS oncogene family. (984 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1282 aa)
	STXBP3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
	SYK	Spleen associated tyrosine kinase. (636 aa)
	ENPP3	Ectonucleotide pyrophosphatase/phosphodiesterase 3. (874 aa)
	DNASE1	Deoxyribonuclease; Belongs to the DNase I family. (282 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
	NMI	N-myc and STAT interactor. (309 aa)
	SLAMF1	Signaling lymphocytic activation molecule family member 1. (347 aa)
	MILR1	Mast cell immunoglobulin like receptor 1. (298 aa)
	KIT	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (979 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (258 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa)
	STXBP2	Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (604 aa)
	DOCK2	Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
	PTGDS	Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] (364 aa)
	IFI35	Interferon induced protein 35. (287 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA3	STXBP2	ENSFCAP00000059398	ENSFCAP00000001480	Annexin.	Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family.	0.408
CLNK	PLCG2	ENSFCAP00000050283	ENSFCAP00000042164	Cytokine dependent hematopoietic cell linker.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.495
CPLX2	SNAP23	ENSFCAP00000037805	ENSFCAP00000060785	Complexin 2.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.828
CPLX2	STXBP2	ENSFCAP00000037805	ENSFCAP00000001480	Complexin 2.	Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family.	0.531
CPLX2	STXBP3	ENSFCAP00000037805	ENSFCAP00000016548	Complexin 2.	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family.	0.461
CPLX2	VAMP2	ENSFCAP00000037805	ENSFCAP00000060327	Complexin 2.	V-SNARE coiled-coil homology domain-containing protein.	0.873
CPLX2	VAMP7	ENSFCAP00000037805	ENSFCAP00000022799	Complexin 2.	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family.	0.548
CX3CR1	IFNG	ENSFCAP00000002514	ENSFCAP00000008355	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.735
CX3CR1	LOC100302540	ENSFCAP00000002514	ENSFCAP00000034226	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.831
CX3CR1	TREM2	ENSFCAP00000002514	ENSFCAP00000002549	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	Triggering receptor expressed on myeloid cells 2.	0.828
CX3CR1	TYROBP	ENSFCAP00000002514	ENSFCAP00000052951	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	TYRO protein tyrosine kinase binding protein.	0.641
DNASE1L3	ENPP3	ENSFCAP00000026662	ENSFCAP00000013106	Deoxyribonuclease; Belongs to the DNase I family.	Ectonucleotide pyrophosphatase/phosphodiesterase 3.	0.447
DOCK2	RASGRP1	ENSFCAP00000000775	ENSFCAP00000055586	Dedicator of cytokinesis 2; Belongs to the DOCK family.	RAS guanyl releasing protein 1.	0.402
ENPP3	DNASE1L3	ENSFCAP00000013106	ENSFCAP00000026662	Ectonucleotide pyrophosphatase/phosphodiesterase 3.	Deoxyribonuclease; Belongs to the DNase I family.	0.447
FCER1G	IFNG	ENSFCAP00000038509	ENSFCAP00000008355	Fc fragment of IgE receptor Ig.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.426
FCER1G	PLCG2	ENSFCAP00000038509	ENSFCAP00000042164	Fc fragment of IgE receptor Ig.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.687
FCER1G	SYK	ENSFCAP00000038509	ENSFCAP00000013189	Fc fragment of IgE receptor Ig.	Spleen associated tyrosine kinase.	0.997
FCER1G	TREM2	ENSFCAP00000038509	ENSFCAP00000002549	Fc fragment of IgE receptor Ig.	Triggering receptor expressed on myeloid cells 2.	0.767
FCER1G	TYROBP	ENSFCAP00000038509	ENSFCAP00000052951	Fc fragment of IgE receptor Ig.	TYRO protein tyrosine kinase binding protein.	0.971
HAVCR2	IFNG	ENSFCAP00000028327	ENSFCAP00000008355	Hepatitis A virus cellular receptor 2.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.551