STRINGSTRING
NLRP6 NLRP6 ITIH4 ITIH4 TREM1 TREM1 AHSG AHSG F12 F12 ELANE ELANE ENSFCAP00000053572 ENSFCAP00000053572 F8 F8 HP HP SAA1 SAA1 C2CD4B C2CD4B ANO6 ANO6 ENSFCAP00000044386 ENSFCAP00000044386 EXT1 EXT1 C2CD4C C2CD4C IL31RA IL31RA LOC101099498 LOC101099498 LOC101099075 LOC101099075 EIF2AK1 EIF2AK1 IL6 IL6 LOC101087936 LOC101087936 PRCP PRCP B4GALT1 B4GALT1 F2 F2 ITIH3 ITIH3 EPHB6 EPHB6 CD6 CD6 F3 F3 LOC111559090 LOC111559090 NUPR1 NUPR1 FN1 FN1 IL1A IL1A TRPV1 TRPV1 SIGIRR SIGIRR SERPINF2 SERPINF2 IL1B IL1B CD163 CD163 MYLK3 MYLK3 ORM2 ORM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NLRP6NLR family pyrin domain containing 6. (878 aa)
ITIH4Inter-alpha-trypsin inhibitor heavy chain 4. (893 aa)
TREM1Triggering receptor expressed on myeloid cells 1. (301 aa)
AHSGAlpha 2-HS glycoprotein. (371 aa)
F12Coagulation factor XII. (639 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (339 aa)
ENSFCAP00000053572Uncharacterized protein. (1072 aa)
F8Coagulation factor VIII; Belongs to the multicopper oxidase family. (2337 aa)
HPHaptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. (349 aa)
SAA1Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (163 aa)
C2CD4BUncharacterized protein. (404 aa)
ANO6Anoctamin. (932 aa)
ENSFCAP00000044386Uncharacterized protein. (156 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
C2CD4CC2 calcium dependent domain containing 4C. (480 aa)
IL31RAInterleukin 31 receptor A. (661 aa)
LOC101099498Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (129 aa)
LOC101099075Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (641 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
LOC101087936Uncharacterized protein. (373 aa)
PRCPProlylcarboxypeptidase. (548 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (400 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
ITIH3Inter-alpha-trypsin inhibitor heavy chain 3. (891 aa)
EPHB6EPH receptor B6. (1012 aa)
CD6CD6 molecule. (678 aa)
F3Coagulation factor III, tissue factor. (379 aa)
LOC111559090Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (129 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
FN1Fibronectin 1. (2475 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (841 aa)
SIGIRRSingle Ig and TIR domain containing. (410 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (565 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
CD163CD163 molecule. (1102 aa)
MYLK3Myosin light chain kinase 3. (800 aa)
ORM2Lipocln_cytosolic_FA-bd_dom domain-containing protein. (239 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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