Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
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Neighborhood
Groups of genes that are frequently observed in each other's genomic neighborhood.
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Databases
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Fusion
Genes that are sometimes fused into single open reading frames.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXP3
Forkhead box P3. (501 aa)
IDO1
Indoleamine 2,3-dioxygenase 1. (407 aa)
ITCH
E3 ubiquitin-protein ligase. (862 aa)
LOC101082108
Ig-like domain-containing protein. (386 aa)
CBLB
Cbl proto-oncogene B. (1182 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685 Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat