STRINGSTRING
GATA3 GATA3 CD28 CD28 STAT6 STAT6 RIPK2 RIPK2 RIF1 RIF1 CLCF1 CLCF1 MAP3K7 MAP3K7 KMT5C KMT5C ZBTB1 ZBTB1 TP53BP1 TP53BP1 NLRP3 NLRP3 M3X1V3_FELCA M3X1V3_FELCA LOC101087936 LOC101087936 TNFSF13B TNFSF13B CD226 CD226 IL12RB1 IL12RB1 B2M B2M LOC105260178 LOC105260178 IL27RA IL27RA FCER2 FCER2 DENND1B DENND1B CLEC7A CLEC7A ADA ADA PTPRC PTPRC ARID5A ARID5A SHLD2 SHLD2 PRKCZ PRKCZ NFKBIZ NFKBIZ TNF TNF EXOSC6 EXOSC6 LOC101081130 LOC101081130 TRAF6 TRAF6 HMCES HMCES ENSFCAP00000046406 ENSFCAP00000046406 CLEC6A CLEC6A FADD FADD MALT1 MALT1 FOXP3 FOXP3 LOC111556311 LOC111556311 STX7 STX7 FAM49B FAM49B PRKCQ PRKCQ IL18R1 IL18R1 LOC101089770 LOC101089770 TFRC TFRC CARD9 CARD9 RSAD2 RSAD2 EXOSC3 EXOSC3 CD1E CD1E IL12B IL12B IL18 IL18 IL23A IL23A IL12A IL12A NSD2 NSD2 TBX21 TBX21 KMT5B KMT5B CD1B CD1B NOD2 NOD2 PAXIP1 PAXIP1 CD81 CD81 ATAD5 ATAD5 FBXO38 FBXO38 IL1B IL1B SASH3 SASH3 TGFB1 TGFB1 LTA LTA SLAMF1 SLAMF1 TREM2 TREM2 IL4 IL4 IL23R IL23R TRAF2 TRAF2 PVR PVR MAD2L2 MAD2L2 P2RX7 P2RX7 MSH2 MSH2 ZP3 ZP3 IL2 IL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GATA3GATA binding protein 3. (444 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
RIF1Replication timing regulatory factor 1. (2479 aa)
CLCF1Cardiotrophin like cytokine factor 1. (340 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
KMT5CLysine methyltransferase 5C. (614 aa)
ZBTB1Zinc finger and BTB domain containing 1. (644 aa)
TP53BP1Tumor protein p53 binding protein 1. (1977 aa)
NLRP3NLR family pyrin domain containing 3. (1038 aa)
M3X1V3_FELCAIg-like domain-containing protein. (313 aa)
LOC101087936Uncharacterized protein. (373 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (357 aa)
CD226CD226 molecule. (332 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (673 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (118 aa)
LOC105260178Ig-like domain-containing protein. (357 aa)
IL27RAInterleukin 27 receptor subunit alpha. (693 aa)
FCER2Fc fragment of IgE receptor II. (290 aa)
DENND1BDENN domain containing 1B. (817 aa)
CLEC7AC-type lectin domain containing 7A. (250 aa)
ADAAdenosine deaminase. (431 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
ARID5AAT-rich interaction domain 5A. (608 aa)
SHLD2Shieldin complex subunit 2. (1045 aa)
PRKCZProtein kinase C zeta. (649 aa)
NFKBIZNFKB inhibitor zeta. (956 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
EXOSC6Exosome component 6. (272 aa)
LOC101081130AIG1-type G domain-containing protein. (309 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (351 aa)
ENSFCAP00000046406MHC_I-like_Ag-recog domain-containing protein. (242 aa)
CLEC6AC-type lectin domain containing 6A. (212 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
MALT1MALT1 paracaspase. (848 aa)
FOXP3Forkhead box P3. (501 aa)
LOC111556311Uncharacterized protein. (857 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (261 aa)
FAM49BFamily with sequence similarity 49 member B. (378 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
IL18R1Interleukin 18 receptor 1. (539 aa)
LOC101089770Uncharacterized protein. (715 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity); Belongs to the [...] (789 aa)
CARD9Caspase recruitment domain family member 9. (732 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (363 aa)
EXOSC3Exosome component 3. (450 aa)
CD1ECD1e molecule. (419 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
IL23AInterleukin 23 subunit alpha. (196 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1350 aa)
TBX21T-box transcription factor 21. (535 aa)
KMT5BLysine methyltransferase 5B. (888 aa)
CD1BCD1b molecule. (332 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
PAXIP1PAX interacting protein 1. (1016 aa)
CD81Tetraspanin. (236 aa)
ATAD5ATPase family AAA domain containing 5. (1893 aa)
FBXO38F-box protein 38. (1155 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
SASH3SAM and SH3 domain containing 3. (379 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LTATumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. (205 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (347 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (258 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
IL23RInterleukin 23 receptor. (631 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
PVRPVR cell adhesion molecule. (380 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (593 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
ZP3Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. (435 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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