STRINGSTRING
CCL19 CCL19 ENSFCAP00000061110 ENSFCAP00000061110 WNT5A WNT5A CXCL12 CXCL12 KITLG KITLG LOC101093854 LOC101093854 NTN1 NTN1 TNFSF4 TNFSF4 IL5 IL5 LOC105261327 LOC105261327 LOC102900387 LOC102900387 ENSFCAP00000057442 ENSFCAP00000057442 SECTM1 SECTM1 LOC101094344 LOC101094344 WNT5B WNT5B IL16 IL16 CKLF CKLF CMTM7 CMTM7 IL32 IL32 IL36G IL36G TNFRSF11B TNFRSF11B CXCL13 CXCL13 IL11 IL11 ENSFCAP00000053861 ENSFCAP00000053861 LOC101091743 LOC101091743 MIF MIF THPO THPO ENSFCAP00000052225 ENSFCAP00000052225 LOC111559734 LOC111559734 GDF7 GDF7 TNFSF10 TNFSF10 BMP4 BMP4 CXCL17 CXCL17 TNF TNF ENSFCAP00000050587 ENSFCAP00000050587 VEGFA VEGFA BMP8B BMP8B CNTF CNTF IL1RN IL1RN WNT4 WNT4 WNT6 WNT6 CTF1 CTF1 WNT7A WNT7A ALKAL2 ALKAL2 GPI GPI CXCL9 CXCL9 WNT9A WNT9A GREM2 GREM2 LOC101092676 LOC101092676 WNT2B WNT2B INHBA INHBA LTB LTB SPP1 SPP1 LOC101094096 LOC101094096 FAM3B FAM3B LOC111558008 LOC111558008 IL17C IL17C ALKAL1 ALKAL1 CXCL10 CXCL10 NAMPT NAMPT VSTM1 VSTM1 C10orf99 C10orf99 CCL26 CCL26 WNT10B WNT10B LOC111560177 LOC111560177 CCL7 CCL7 LOC100302541 LOC100302541 IL1F10 IL1F10 SCGB3A1 SCGB3A1 BMP8A BMP8A INHBB INHBB WNT10A WNT10A IFNA13 IFNA13 CXCL11 CXCL11 CCL27 CCL27 CCL22 CCL22 CSF3 CSF3 IL13 IL13 WNT3A WNT3A OSM OSM GDF5 GDF5 LIF LIF LOC100302540 LOC100302540 IL25 IL25 ENSFCAP00000033605 ENSFCAP00000033605 IL17A IL17A CD40LG CD40LG FASLG FASLG IL31 IL31 IFNA1 IFNA1 IL7 IL7 CCL28 CCL28 IL17D IL17D TNFSF9 TNFSF9 BMP2 BMP2 NDP NDP WNT2 WNT2 ENSFCAP00000028308 ENSFCAP00000028308 C1QTNF4 C1QTNF4 INHBC INHBC IL18 IL18 GDF10 GDF10 IL12B IL12B IL36RN IL36RN BMP10 BMP10 CMTM3 CMTM3 IFNW1 IFNW1 BMP6 BMP6 IL34 IL34 GDF6 GDF6 WNT16 WNT16 FLT3LG FLT3LG IL6 IL6 CCL13 CCL13 M3X652_FELCA M3X652_FELCA BMP15 BMP15 LOC101081599 LOC101081599 IL-29 IL-29 WNT11 WNT11 WNT7B WNT7B LOC101088440 LOC101088440 CCL24 CCL24 CXCL16 CXCL16 GDF11 GDF11 SCG2 SCG2 CLCF1 CLCF1 IL15 IL15 MSTN MSTN IL22 IL22 CMTM2 CMTM2 CXCL6 CXCL6 EDN1 EDN1 TGFB3 TGFB3 IL9 IL9 CXCL14 CXCL14 IL24 IL24 IL20 IL20 IL2 IL2 CCL8 CCL8 IL10 IL10 GDF9 GDF9 TSLP TSLP IL23A IL23A WNT3 WNT3 IL12A IL12A CSF1 CSF1 IFNL1 IFNL1 IL26 IL26 CCL16 CCL16 GDF3 GDF3 CRLF1 CRLF1 GDF15 GDF15 CMTM5 CMTM5 IL33 IL33 IFNG IFNG IL17F IL17F TIMP1 TIMP1 IL1A IL1A BMP3 BMP3 EPO EPO INHA INHA IL19 IL19 WNT8B WNT8B IL21 IL21 TNFSF11 TNFSF11 IL1B IL1B CCL17 CCL17 CXCL8 CXCL8 IFNB1 IFNB1 LTA LTA BMP5 BMP5 CSF2 CSF2 IL17B IL17B CCL20 CCL20 INHBE INHBE CCL21 CCL21 IL4 IL4 WNT8A WNT8A CCL5 CCL5 NODAL NODAL CCL2 CCL2 WNT9B WNT9B WNT1 WNT1 CX3CL1 CX3CL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCL19C-C motif chemokine. (115 aa)
ENSFCAP00000061110TGF_BETA_2 domain-containing protein. (362 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (457 aa)
CXCL12Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4 [...] (143 aa)
KITLGSoluble KIT ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity). (274 aa)
LOC101093854C-X-C motif chemokine. (96 aa)
NTN1Netrin 1. (715 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (295 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
LOC105261327Left-right determination factor. (367 aa)
LOC102900387Uncharacterized protein. (203 aa)
ENSFCAP00000057442Uncharacterized protein. (140 aa)
SECTM1Uncharacterized protein. (560 aa)
LOC101094344C-X-C motif chemokine. (113 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (443 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1375 aa)
CKLFChemokine like factor. (150 aa)
CMTM7MARVEL domain-containing protein. (562 aa)
IL32Uncharacterized protein. (173 aa)
IL36GInterleukin-1. (219 aa)
TNFRSF11BTNF receptor superfamily member 11b. (414 aa)
CXCL13C-X-C motif chemokine. (120 aa)
IL11Interleukin 11. (424 aa)
ENSFCAP00000053861Uncharacterized protein. (220 aa)
LOC101091743Uncharacterized protein. (185 aa)
MIFMacrophage migration inhibitory factor. (190 aa)
THPOThrombopoietin. (409 aa)
ENSFCAP00000052225C-C motif chemokine. (80 aa)
LOC111559734Bone morphogenetic protein 7. (426 aa)
GDF7Growth differentiation factor 7. (455 aa)
TNFSF10TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (347 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CXCL17C-X-C motif chemokine ligand 17. (119 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
ENSFCAP00000050587SCY domain-containing protein. (157 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (450 aa)
BMP8BTGF_BETA_2 domain-containing protein. (402 aa)
CNTFCiliary neurotrophic factor. (200 aa)
IL1RNInterleukin-1. (182 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CTF1Cardiotrophin 1. (237 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ALKAL2Uncharacterized protein. (60 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (659 aa)
CXCL9C-X-C motif chemokine. (155 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (187 aa)
LOC101092676TGF_BETA_2 domain-containing protein. (410 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa)
LTBLymphotoxin beta; Belongs to the tumor necrosis factor family. (312 aa)
SPP1Secreted phosphoprotein 1. (299 aa)
LOC101094096C-X-C motif chemokine. (104 aa)
FAM3BFamily with sequence similarity 3 member B. (235 aa)
LOC111558008Uncharacterized protein. (195 aa)
IL17CUncharacterized protein. (198 aa)
ALKAL1Uncharacterized protein. (283 aa)
CXCL10C-X-C motif chemokine. (98 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (507 aa)
VSTM1V-set and transmembrane domain containing 1. (234 aa)
C10orf99Chromosome 10 open reading frame 99. (81 aa)
CCL26C-C motif chemokine. (94 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LOC111560177C-X-C motif chemokine. (138 aa)
CCL7C-C motif chemokine. (99 aa)
LOC100302541C-C motif chemokine. (102 aa)
IL1F10Interleukin-1. (152 aa)
SCGB3A1Uncharacterized protein. (122 aa)
BMP8ATGF_BETA_2 domain-containing protein. (402 aa)
INHBBInhibin subunit beta B. (407 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
IFNA13Uncharacterized protein. (193 aa)
CXCL11C-X-C motif chemokine. (100 aa)
CCL27C-C motif chemokine ligand 27. (113 aa)
CCL22C-C motif chemokine. (93 aa)
CSF3Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes (By similarity); Belongs to the IL-6 superfamily. (204 aa)
IL13Interleukin 13. (144 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
OSMOncostatin M. (238 aa)
GDF5Growth differentiation factor 5. (499 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
LOC100302540C-C motif chemokine. (93 aa)
IL25Interleukin 25. (161 aa)
ENSFCAP00000033605Uncharacterized protein. (147 aa)
IL17AInterleukin 17A. (155 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
IL31Interleukin 31. (159 aa)
IFNA1Interferon alpha; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (194 aa)
IL7Interleukin 7. (158 aa)
CCL28C-C motif chemokine. (127 aa)
IL17DInterleukin 17D. (202 aa)
TNFSF9TNF superfamily member 9; Belongs to the tumor necrosis factor family. (250 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
NDPNorrin cystine knot growth factor NDP. (133 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
ENSFCAP00000028308Uncharacterized protein. (188 aa)
C1QTNF4C1q domain-containing protein. (98 aa)
INHBCInhibin subunit beta C. (353 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
GDF10Growth differentiation factor 10. (503 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
IL36RNInterleukin-1. (196 aa)
BMP10TGF_BETA_2 domain-containing protein. (424 aa)
CMTM3CKLF like MARVEL transmembrane domain containing 3. (379 aa)
IFNW1Uncharacterized protein. (196 aa)
BMP6Bone morphogenetic protein 6. (502 aa)
IL34Interleukin 34. (331 aa)
GDF6TGF_BETA_2 domain-containing protein. (462 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (291 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
CCL13C-C motif chemokine. (98 aa)
M3X652_FELCAUncharacterized protein. (164 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
LOC101081599SCY domain-containing protein. (158 aa)
IL-29Uncharacterized protein. (190 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
LOC101088440Uncharacterized protein. (183 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
CXCL16C-X-C motif chemokine ligand 16. (251 aa)
GDF11Growth differentiation factor 11. (404 aa)
SCG2Secretogranin II. (680 aa)
CLCF1Cardiotrophin like cytokine factor 1. (340 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (162 aa)
MSTNMyostatin. (375 aa)
IL22Interleukin 22. (179 aa)
CMTM2CKLF like MARVEL transmembrane domain containing 2. (259 aa)
CXCL6C-X-C motif chemokine. (148 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL9Interleukin 9. (141 aa)
CXCL14C-X-C motif chemokine ligand 14. (110 aa)
IL24Interleukin 24. (192 aa)
IL20Interleukin 20. (176 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
CCL8C-C motif chemokine. (99 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
GDF9Growth differentiation factor 9. (452 aa)
TSLPThymic stromal lymphopoietin. (224 aa)
IL23AInterleukin 23 subunit alpha. (196 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (569 aa)
IFNL1Uncharacterized protein. (199 aa)
IL26Interleukin 26. (171 aa)
CCL16C-C motif chemokine. (107 aa)
GDF3Growth differentiation factor 3. (365 aa)
CRLF1Cytokine receptor like factor 1. (421 aa)
GDF15Growth differentiation factor 15. (307 aa)
CMTM5CKLF like MARVEL transmembrane domain containing 5. (186 aa)
IL33Interleukin 33. (268 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
IL17FInterleukin 17F. (157 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (305 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (192 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
IL19Interleukin 19. (177 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
CCL17C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). (99 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
LTATumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. (205 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (142 aa)
IL17BInterleukin 17B. (180 aa)
CCL20C-C motif chemokine. (97 aa)
INHBEInhibin subunit beta E. (349 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
NODALNodal growth differentiation factor. (348 aa)
CCL2C-C motif chemokine. (99 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (449 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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