STRINGSTRING
PABPN1 PABPN1 MCL1 MCL1 SH3GLB1 SH3GLB1 ARMCX3 ARMCX3 CISD2 CISD2 ATF2 ATF2 FOXO3 FOXO3 TOMM20 TOMM20 RPS6KB1 RPS6KB1 PHB2 PHB2 FUNDC2 FUNDC2 TRIM14 TRIM14 VDAC2 VDAC2 TOMM70 TOMM70 MTCH2 MTCH2 TAZ TAZ FATE1 FATE1 MIEF1 MIEF1 WASF1 WASF1 PNPLA3 PNPLA3 HADHB HADHB GCK GCK GDAP1 GDAP1 ATAD1 ATAD1 VAT1 VAT1 MAOB MAOB BCL2A1 BCL2A1 SNN SNN MYO19 MYO19 DAO DAO ABCB6 ABCB6 SPATA19 SPATA19 USP30 USP30 DMPK DMPK LETMD1 LETMD1 CPT1C CPT1C HK2 HK2 RHOT2 RHOT2 HK1 HK1 HKDC1 HKDC1 HK3 HK3 MTARC1 MTARC1 TOMM22 TOMM22 SOX10 SOX10 LRRK2 LRRK2 STING1 STING1 ZNFX1 ZNFX1 PINK1 PINK1 VPS13A VPS13A BAX BAX RTN4IP1 RTN4IP1 AGPAT4 AGPAT4 MTX1 MTX1 BCL2 BCL2 BNIP3 BNIP3 MGST1 MGST1 LOC101083598 LOC101083598 ENSFCAP00000060319 ENSFCAP00000060319 MUL1 MUL1 ENSFCAP00000059861 ENSFCAP00000059861 MIGA2 MIGA2 BAK1 BAK1 BCL2L1 BCL2L1 ENSFCAP00000058976 ENSFCAP00000058976 MSTO1 MSTO1 SPATA18 SPATA18 ENSFCAP00000057645 ENSFCAP00000057645 BOK BOK MFF MFF ENSFCAP00000056164 ENSFCAP00000056164 VDAC3 VDAC3 BID BID QTRT1 QTRT1 BNIP5 BNIP5 CPT1A CPT1A TOMM34 TOMM34 AIFM2 AIFM2 SLC25A46 SLC25A46 GPAM GPAM TOMM20L TOMM20L TIGAR TIGAR OPA1 OPA1 MGARP MGARP SAMD15 SAMD15 SYNJ2BP SYNJ2BP BAD BAD TOMM40 TOMM40 MAOA MAOA MTX2 MTX2 PDE2A PDE2A FAM210B FAM210B RHOT1 RHOT1 BCL2L2 BCL2L2 LOC101099553 LOC101099553 PPP1R15A PPP1R15A GK2 GK2 BCL2L10 BCL2L10 CYB5R3 CYB5R3 LOC111558941 LOC111558941 FIS1 FIS1 RAB11FIP5 RAB11FIP5 TOMM7 TOMM7 ENSFCAP00000039133 ENSFCAP00000039133 HAX1 HAX1 ARMC1 ARMC1 VDAC1 VDAC1 GK GK CISD1 CISD1 LPIN1 LPIN1 TOMM5 TOMM5 PGRMC1 PGRMC1 LOC101083640 LOC101083640 ENSFCAP00000033718 ENSFCAP00000033718 TOMM40L TOMM40L SPIRE1 SPIRE1 MYOC MYOC RMDN3 RMDN3 MFN1 MFN1 ENSFCAP00000031232 ENSFCAP00000031232 QTRT2 QTRT2 RSAD2 RSAD2 PI4KB PI4KB CPT1B CPT1B PLD6 PLD6 MARCHF5 MARCHF5 TOMM6 TOMM6 SPART SPART MTX3 MTX3 MFN2 MFN2 MIEF2 MIEF2 ENSFCAP00000026617 ENSFCAP00000026617 FUNDC1 FUNDC1 NECTIN2 NECTIN2 BNIP3L BNIP3L KMO KMO VPS13C VPS13C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PABPN1Poly(A) binding protein nuclear 1. (306 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). (350 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (401 aa)
ARMCX3Armadillo repeat containing X-linked 3. (379 aa)
CISD2CDGSH iron sulfur domain 2. (135 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
FOXO3Forkhead box O3. (672 aa)
TOMM20Translocase of outer mitochondrial membrane 20. (145 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PHB2Prohibitin. (299 aa)
FUNDC2FUN14 domain containing 2. (190 aa)
TRIM14Tripartite motif containing 14. (445 aa)
VDAC2Voltage dependent anion channel 2. (294 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (609 aa)
MTCH2Mitochondrial carrier 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (303 aa)
TAZTafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (262 aa)
FATE1Fetal and adult testis expressed 1. (183 aa)
MIEF1Mitochondrial elongation factor 1. (463 aa)
WASF1WASP family member 1. (570 aa)
PNPLA3Uncharacterized protein. (919 aa)
HADHBHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
GCKPhosphotransferase. (466 aa)
GDAP1Ganglioside induced differentiation associated protein 1; Belongs to the GST superfamily. (358 aa)
ATAD1ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (360 aa)
VAT1Vesicle amine transport 1. (391 aa)
MAOBAmine oxidase. (520 aa)
BCL2A1BCL2 related protein A1. (174 aa)
SNNStannin. (87 aa)
MYO19Myosin XIX; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (974 aa)
DAOD-amino acid oxidase. (347 aa)
ABCB6ATP binding cassette subfamily B member 6. (845 aa)
SPATA19Spermatogenesis associated 19. (154 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (519 aa)
DMPKDM1 protein kinase. (801 aa)
LETMD1LETM1 domain containing 1. (375 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
HK2Hexokinase 2. (917 aa)
RHOT2Ras homolog family member T2. (722 aa)
HK1Hexokinase 1. (1056 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
HK3Hexokinase 3. (924 aa)
MTARC1Mitochondrial amidoxime reducing component 2. (535 aa)
TOMM22Translocase of outer mitochondrial membrane 22. (142 aa)
SOX10SRY-box transcription factor 10. (604 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
STING1Stimulator of interferon genes. (377 aa)
ZNFX1Zinc finger NFX1-type containing 1. (1918 aa)
PINK1PTEN induced kinase 1. (581 aa)
VPS13AVacuolar protein sorting 13 homolog A. (3172 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
RTN4IP1Reticulon 4 interacting protein 1. (445 aa)
AGPAT41-acylglycerol-3-phosphate O-acyltransferase 4. (473 aa)
MTX1Metaxin 1. (517 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
BNIP3BCL2 interacting protein 3. (187 aa)
MGST1Microsomal glutathione S-transferase 1. (176 aa)
LOC101083598CheR domain-containing protein. (386 aa)
ENSFCAP00000060319Uncharacterized protein. (108 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (568 aa)
ENSFCAP00000059861GST_C_6 domain-containing protein. (313 aa)
MIGA2Mitoguardin 2. (644 aa)
BAK1BCL2 antagonist/killer 1. (251 aa)
BCL2L1BCL2 like 1. (271 aa)
ENSFCAP00000058976Uncharacterized protein. (105 aa)
MSTO1Misato mitochondrial distribution and morphology regulator 1. (812 aa)
SPATA18Spermatogenesis associated 18. (540 aa)
ENSFCAP00000057645Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (150 aa)
BOKBCL2 family apoptosis regulator BOK. (320 aa)
MFFMitochondrial fission factor. (357 aa)
ENSFCAP00000056164Uncharacterized protein. (88 aa)
VDAC3Voltage dependent anion channel 3. (315 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa)
QTRT1Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (396 aa)
BNIP5BCL2 interacting protein 5. (625 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
TOMM34Uncharacterized protein. (372 aa)
AIFM2Apoptosis inducing factor mitochondria associated 2. (491 aa)
SLC25A46Solute carrier family 25 member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (419 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (796 aa)
TOMM20LTranslocase of outer mitochondrial membrane 20 like. (152 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (428 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
MGARPMitochondria localized glutamic acid rich protein. (241 aa)
SAMD15SAM domain-containing protein. (709 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
BADBCL2 associated agonist of cell death. (273 aa)
TOMM40Translocase of outer mitochondrial membrane 40. (361 aa)
MAOAAmine oxidase. (1178 aa)
MTX2Metaxin 2. (285 aa)
PDE2APhosphodiesterase. (942 aa)
FAM210BFamily with sequence similarity 210 member B. (192 aa)
RHOT1Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (720 aa)
BCL2L2BCL2 like 2. (193 aa)
LOC101099553Uncharacterized protein; Belongs to the FGGY kinase family. (537 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (685 aa)
GK2Glycerol kinase 2; Belongs to the FGGY kinase family. (553 aa)
BCL2L10Uncharacterized protein. (192 aa)
CYB5R3NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (272 aa)
LOC111558941Uncharacterized protein. (291 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
RAB11FIP5RAB11 family interacting protein 5. (1314 aa)
TOMM7Translocase of outer mitochondrial membrane 7. (55 aa)
ENSFCAP00000039133Uncharacterized protein. (158 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (281 aa)
ARMC1Armadillo repeat-containing protein 1. (282 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
GKUncharacterized protein; Belongs to the FGGY kinase family. (584 aa)
CISD1CDGSH iron sulfur domain 1. (165 aa)
LPIN1Lipin 1. (976 aa)
TOMM5Uncharacterized protein. (51 aa)
PGRMC1Progesterone receptor membrane component 1; Belongs to the cytochrome b5 family. (195 aa)
LOC101083640Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (150 aa)
ENSFCAP00000033718ZnF_CDGSH domain-containing protein. (99 aa)
TOMM40LTranslocase of outer mitochondrial membrane 40 like. (324 aa)
SPIRE1Spire type actin nucleation factor 1. (810 aa)
MYOCMyocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...] (498 aa)
RMDN3Regulator of microtubule dynamics 3. (473 aa)
MFN1Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (804 aa)
ENSFCAP00000031232Uncharacterized protein. (108 aa)
QTRT2Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (415 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (363 aa)
PI4KBPhosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (861 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
PLD6Phospholipase D family member 6. (229 aa)
MARCHF5Membrane associated ring-CH-type finger 5. (278 aa)
TOMM6Translocase of outer mitochondrial membrane 6. (74 aa)
SPARTSpartin. (672 aa)
MTX3Metaxin. (312 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
MIEF2Mitochondrial elongation factor 2. (453 aa)
ENSFCAP00000026617Ubiquitin-like domain-containing protein. (78 aa)
FUNDC1Uncharacterized protein. (155 aa)
NECTIN2Nectin cell adhesion molecule 2. (539 aa)
BNIP3LBCL2 interacting protein 3 like. (219 aa)
KMOKynurenine 3-monooxygenase. (453 aa)
VPS13CVacuolar protein sorting 13 homolog C. (3752 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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