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DDAH1 DDAH1 KLRK1 KLRK1 ENSFCAP00000057645 ENSFCAP00000057645 CYP1B1 CYP1B1 CYB5R3 CYB5R3 RORA RORA NOS2 NOS2 SPR SPR LOC101083640 LOC101083640 CAV1 CAV1 TLR4 TLR4 NOS1 NOS1 NOS3 NOS3 MTARC1 MTARC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDAH1Dimethylarginine dimethylaminohydrolase 1. (330 aa)
KLRK1Killer cell lectin like receptor K1. (215 aa)
ENSFCAP00000057645Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (150 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (553 aa)
CYB5R3NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (272 aa)
RORARAR related orphan receptor A. (523 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
SPRSepiapterin reductase. (267 aa)
LOC101083640Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (150 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
NOS1Nitric oxide synthase 1. (1462 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
MTARC1Mitochondrial amidoxime reducing component 2. (535 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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