STRINGSTRING
F8 F8 FN1 FN1 IL1A IL1A TRPV1 TRPV1 SIGIRR SIGIRR SERPINF2 SERPINF2 IL1B IL1B ENSFCAP00000053572 ENSFCAP00000053572 AHSG AHSG ITIH3 ITIH3 ITIH4 ITIH4 CD163 CD163 ORM2 ORM2 F2 F2 LOC111559090 LOC111559090 IL6 IL6 LOC101099075 LOC101099075 LOC101099498 LOC101099498 ENSFCAP00000044386 ENSFCAP00000044386 SAA1 SAA1 HP HP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F8Coagulation factor VIII; Belongs to the multicopper oxidase family. (2337 aa)
FN1Fibronectin 1. (2475 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (841 aa)
SIGIRRSingle Ig and TIR domain containing. (410 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (565 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
ENSFCAP00000053572Uncharacterized protein. (1072 aa)
AHSGAlpha 2-HS glycoprotein. (371 aa)
ITIH3Inter-alpha-trypsin inhibitor heavy chain 3. (891 aa)
ITIH4Inter-alpha-trypsin inhibitor heavy chain 4. (893 aa)
CD163CD163 molecule. (1102 aa)
ORM2Lipocln_cytosolic_FA-bd_dom domain-containing protein. (239 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
LOC111559090Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (129 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (233 aa)
LOC101099075Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
LOC101099498Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (129 aa)
ENSFCAP00000044386Uncharacterized protein. (156 aa)
SAA1Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (163 aa)
HPHaptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. (349 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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