STRINGSTRING
DEGS1 DEGS1 CRB1 CRB1 SPACA3 SPACA3 BAIAP2L2 BAIAP2L2 SLC4A1 SLC4A1 SYTL4 SYTL4 AKT3 AKT3 CHMP2A CHMP2A VMP1 VMP1 TLCD1 TLCD1 ABCD1 ABCD1 BIN2 BIN2 AKT1 AKT1 STX2 STX2 TLCD2 TLCD2 TRIM72 TRIM72 LOC101084733 LOC101084733 MICALL2 MICALL2 FLOT1 FLOT1 SH3TC2 SH3TC2 A4GALT A4GALT XKR4 XKR4 LYZL4 LYZL4 MYOF MYOF SPAM1 SPAM1 TRPC5 TRPC5 CSRP3 CSRP3 SNX9 SNX9 TMEM95 TMEM95 PLSCR3 PLSCR3 MPP5 MPP5 ATG9A ATG9A P2RX7 P2RX7 PACSIN3 PACSIN3 LOC101094500 LOC101094500 MYRF MYRF XKR5 XKR5 LLCFC1 LLCFC1 TIE1 TIE1 FA2H FA2H PACSIN1 PACSIN1 SPACA6 SPACA6 FER1L6 FER1L6 M3WPJ7_FELCA M3WPJ7_FELCA PTEN PTEN XKR9 XKR9 FOLR1 FOLR1 XKR7 XKR7 M3WUX1_FELCA M3WUX1_FELCA SYT11 SYT11 CAV2 CAV2 SMPD1 SMPD1 UGCG UGCG MTSS2 MTSS2 SNX18 SNX18 ABCD2 ABCD2 ATP2A2 ATP2A2 TLCD5 TLCD5 CHMP4C CHMP4C PLSCR5 PLSCR5 XKR6 XKR6 COLEC12 COLEC12 ANO9 ANO9 EHD2 EHD2 NDRG1 NDRG1 LOC101086249 LOC101086249 IZUMO1R IZUMO1R XKR8 XKR8 CAV1 CAV1 CLN3 CLN3 ADRM1 ADRM1 CAV3 CAV3 ENSFCAP00000032933 ENSFCAP00000032933 GOSR2 GOSR2 CHMP1A CHMP1A CHMP4A CHMP4A SLC9A3R1 SLC9A3R1 MTSS1 MTSS1 DYSF DYSF BIN1 BIN1 RAB3A RAB3A CD9 CD9 CAVIN2 CAVIN2 ARV1 ARV1 SPTA1 SPTA1 C16orf92 C16orf92 ANO4 ANO4 FNBP1L FNBP1L SYPL2 SYPL2 LOC101085336 LOC101085336 BAIAP2 BAIAP2 ANO6 ANO6 PACSIN2 PACSIN2 SPATA46 SPATA46 LOC101095853 LOC101095853 CHMP2B CHMP2B CLPTM1L CLPTM1L BIN3 BIN3 ANO3 ANO3 CHMP5 CHMP5 PLSCR4 PLSCR4 FER1L5 FER1L5 MYMX MYMX TMEM41B TMEM41B OTOF OTOF ENSFCAP00000051272 ENSFCAP00000051272 MYMK MYMK ENSFCAP00000051990 ENSFCAP00000051990 CHMP6 CHMP6 SPESP1 SPESP1 ENSFCAP00000053074 ENSFCAP00000053074 MICALL1 MICALL1 ENSFCAP00000055447 ENSFCAP00000055447 CHMP7 CHMP7 SH3TC1 SH3TC1 PTPRC PTPRC ANXA6 ANXA6 BAIAP2L1 BAIAP2L1 SNX33 SNX33 DMKN DMKN ANO7 ANO7 AKT2 AKT2 LOC102900416 LOC102900416 PRX PRX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DEGS1Delta 4-desaturase, sphingolipid 1. (336 aa)
CRB1Crumbs cell polarity complex component 1. (1405 aa)
SPACA3Sperm acrosome associated 3; Belongs to the glycosyl hydrolase 22 family. (256 aa)
BAIAP2L2BAI1 associated protein 2 like 2. (562 aa)
SLC4A1Anion exchange protein. (911 aa)
SYTL4Synaptotagmin like 4. (671 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
VMP1Vacuole membrane protein 1. (406 aa)
TLCD1TLC domain containing 1. (247 aa)
ABCD1ATP binding cassette subfamily D member 1. (733 aa)
BIN2Bridging integrator 2. (552 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
STX2Syntaxin 2; Belongs to the syntaxin family. (288 aa)
TLCD2TLC domain containing 2. (262 aa)
TRIM72Tripartite motif containing 72. (477 aa)
LOC101084733Folate_rec domain-containing protein. (248 aa)
MICALL2MICAL like 2. (902 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
SH3TC2SH3 domain and tetratricopeptide repeats 2. (1290 aa)
A4GALTAlpha 1,4-galactosyltransferase (P blood group). (412 aa)
XKR4XK-related protein. (655 aa)
LYZL4Lysozyme like 4; Belongs to the glycosyl hydrolase 22 family. (145 aa)
MYOFMyoferlin. (2080 aa)
SPAM1Hyaluronidase. (508 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
CSRP3Cysteine and glycine rich protein 3. (271 aa)
SNX9Sorting nexin 9. (678 aa)
TMEM95Transmembrane protein 95. (184 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (998 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (593 aa)
PACSIN3Protein kinase C and casein kinase substrate in neurons 3. (424 aa)
LOC101094500Uncharacterized protein. (274 aa)
MYRFMyelin regulatory factor. (1188 aa)
XKR5XK-related protein. (674 aa)
LLCFC1LLLL and CFNLAS motif containing 1. (111 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1137 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
PACSIN1Protein kinase C and casein kinase substrate in neurons 1. (444 aa)
SPACA6Sperm acrosome associated 6. (324 aa)
FER1L6Fer-1 like family member 6. (1869 aa)
M3WPJ7_FELCAUncharacterized protein. (188 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
XKR9XK-related protein. (373 aa)
FOLR1Folate receptor alpha. (302 aa)
XKR7XK-related protein. (581 aa)
M3WUX1_FELCAPhospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (274 aa)
SYT11Synaptotagmin 11. (431 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (262 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (619 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (394 aa)
MTSS2MTSS I-BAR domain containing 2. (1082 aa)
SNX18Sorting nexin. (624 aa)
ABCD2ATP binding cassette subfamily D member 2. (739 aa)
ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1006 aa)
TLCD5TLC domain containing 5. (266 aa)
CHMP4CCharged multivesicular body protein 4C. (237 aa)
PLSCR5Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (267 aa)
XKR6XK-related protein. (632 aa)
COLEC12Collectin subfamily member 12. (753 aa)
ANO9Anoctamin. (769 aa)
EHD2EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (656 aa)
NDRG1N-myc downstream regulated 1. (384 aa)
LOC101086249Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (236 aa)
IZUMO1RIZUMO1 receptor, JUNO. (243 aa)
XKR8XK-related protein. (430 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CLN3Battenin. (438 aa)
ADRM1Oxysterol-binding protein; Belongs to the OSBP family. (853 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
ENSFCAP00000032933Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (155 aa)
GOSR2Uncharacterized protein; Belongs to the glycosyl hydrolase 22 family. (215 aa)
CHMP1ACharged multivesicular body protein 1A. (196 aa)
CHMP4ACharged multivesicular body protein 4A. (220 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
MTSS1MTSS I-BAR domain containing 1. (856 aa)
DYSFDysferlin. (2112 aa)
BIN1Bridging integrator 1. (608 aa)
RAB3ARAB3A, member RAS oncogene family. (220 aa)
CD9CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, [...] (250 aa)
CAVIN2Caveolae associated protein 2. (425 aa)
ARV1ARV1 homolog, fatty acid homeostasis modulator. (283 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2420 aa)
C16orf92Chromosome 16 open reading frame 92. (130 aa)
ANO4Anoctamin. (1153 aa)
FNBP1LFormin binding protein 1 like. (605 aa)
SYPL2Synaptophysin like 2. (266 aa)
LOC101085336Izumo-Ig domain-containing protein. (345 aa)
BAIAP2BAI1 associated protein 2. (548 aa)
ANO6Anoctamin. (932 aa)
PACSIN2Protein kinase C and casein kinase substrate in neurons 2. (525 aa)
SPATA46Spermatogenesis associated 46. (245 aa)
LOC101095853Folate_rec domain-containing protein. (256 aa)
CHMP2BCharged multivesicular body protein 2B. (227 aa)
CLPTM1LCLPTM1 like. (538 aa)
BIN3Bridging integrator 3. (352 aa)
ANO3Anoctamin. (1042 aa)
CHMP5Charged multivesicular body protein 5. (372 aa)
PLSCR4Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (356 aa)
FER1L5Fer-1 like family member 5. (2051 aa)
MYMXMyomixer, myoblast fusion factor. (84 aa)
TMEM41BTransmembrane protein 41B. (291 aa)
OTOFOtoferlin. (1998 aa)
ENSFCAP00000051272Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (277 aa)
MYMKMyomaker, myoblast fusion factor. (221 aa)
ENSFCAP00000051990Izumo-Ig domain-containing protein. (302 aa)
CHMP6Charged multivesicular body protein 6. (263 aa)
SPESP1Sperm equatorial segment protein 1. (343 aa)
ENSFCAP00000053074Ig-like domain-containing protein. (382 aa)
MICALL1MICAL like 1. (849 aa)
ENSFCAP00000055447Izumo-Ig domain-containing protein. (435 aa)
CHMP7Charged multivesicular body protein 7. (456 aa)
SH3TC1SH3 domain and tetratricopeptide repeats 1. (1367 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1299 aa)
ANXA6Annexin. (723 aa)
BAIAP2L1BAI1 associated protein 2 like 1. (530 aa)
SNX33Sorting nexin. (577 aa)
DMKNDermokine. (460 aa)
ANO7Anoctamin. (907 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
LOC102900416IG domain-containing protein. (314 aa)
PRXPeriaxin. (1482 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.