STRINGSTRING
APPL2 APPL2 NODAL NODAL SIRT1 SIRT1 ENSFCAP00000058884 ENSFCAP00000058884 GLG1 GLG1 PTPRK PTPRK TGFBR2 TGFBR2 SMAD2 SMAD2 LPXN LPXN SMAD5 SMAD5 LTBP3 LTBP3 TGFBR1 TGFBR1 FOS FOS CDH5 CDH5 TP53 TP53 SMAD7 SMAD7 SMAD9 SMAD9 FLCN FLCN TGFBR3L TGFBR3L USP15 USP15 SRC SRC ACVRL1 ACVRL1 SKIL SKIL LTBP4 LTBP4 PXN PXN MTMR4 MTMR4 EID2 EID2 SMAD3 SMAD3 ITGB5 ITGB5 NPNT NPNT APPL1 APPL1 TGFB2 TGFB2 CITED1 CITED1 SMAD4 SMAD4 CHST11 CHST11 ONECUT2 ONECUT2 ENG ENG STAT3 STAT3 ADAM9 ADAM9 PML PML SMAD1 SMAD1 HPGD HPGD TGFB1 TGFB1 NRROS NRROS ITGB8 ITGB8 NLK NLK ACVR1 ACVR1 ZMIZ1 ZMIZ1 TAB1 TAB1 LRRC32 LRRC32 TGFBR3 TGFBR3 SMAD6 SMAD6 TGFB3 TGFB3 COL3A1 COL3A1 CDH5-2 CDH5-2 MSTN MSTN COL1A2 COL1A2 CLDN5 CLDN5 WFIKKN2 WFIKKN2 FOXH1 FOXH1 JUN JUN TWSG1 TWSG1 CITED2 CITED2 ZYX ZYX FERMT2 FERMT2 ZFYVE9 ZFYVE9 HIPK2 HIPK2 USP9X USP9X
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
NODALNodal growth differentiation factor. (348 aa)
SIRT1Sirtuin 1. (745 aa)
ENSFCAP00000058884Protein kinase domain-containing protein. (375 aa)
GLG1Golgi glycoprotein 1. (1250 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1485 aa)
TGFBR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (604 aa)
SMAD2Mothers against decapentaplegic homolog. (721 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (387 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1302 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
CDH5Uncharacterized protein. (402 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD9Mothers against decapentaplegic homolog. (430 aa)
FLCNUncharacterized protein. (579 aa)
TGFBR3LZP domain-containing protein. (485 aa)
USP15Ubiquitin specific peptidase 15; Belongs to the peptidase C19 family. (790 aa)
SRCTyrosine-protein kinase. (678 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
SKILSKI like proto-oncogene. (686 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1656 aa)
PXNPaxillin. (1089 aa)
MTMR4Myotubularin related protein 4. (1209 aa)
EID2EP300 interacting inhibitor of differentiation 2. (195 aa)
SMAD3Mothers against decapentaplegic homolog. (457 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
NPNTNephronectin. (612 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (221 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CHST11Carbohydrate sulfotransferase. (395 aa)
ONECUT2One cut domain family member. (504 aa)
ENGEndoglin. (654 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
PMLPromyelocytic leukemia. (876 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1066 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
LRRC32Leucine rich repeat containing 32. (663 aa)
TGFBR3Transforming growth factor beta receptor 3. (828 aa)
SMAD6Mothers against decapentaplegic homolog. (497 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
CDH5-2Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (314 aa)
MSTNMyostatin. (375 aa)
COL1A2Collagen type I alpha 2 chain. (1367 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (573 aa)
FOXH1Forkhead box H1. (361 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
ZYXZyxin. (913 aa)
FERMT2Fermitin family member 2. (706 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1424 aa)
HIPK2Homeodomain interacting protein kinase 2. (1222 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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