STRINGSTRING
PRKD1 PRKD1 RAB9B RAB9B BRAP BRAP PLEKHG5 PLEKHG5 RASGRP4 RASGRP4 MYO9B MYO9B CDC42EP2 CDC42EP2 KSR2 KSR2 FARP2 FARP2 HRAS HRAS RHOG RHOG CDH13 CDH13 ITGA3 ITGA3 ELMO1 ELMO1 CDC42 CDC42 RGL3 RGL3 RAP2B RAP2B PLCE1 PLCE1 IQGAP3 IQGAP3 BCL6 BCL6 DOK1 DOK1 PDPN PDPN WASF2 WASF2 USP50 USP50 HACD3 HACD3 RALGPS1 RALGPS1 KSR1 KSR1 RACGAP1 RACGAP1 RRAS2 RRAS2 RASGRP3 RASGRP3 RIT2 RIT2 CSF1 CSF1 BRK1 BRK1 GDI1 GDI1 RALGPS2 RALGPS2 RHOH RHOH RGL1 RGL1 CNKSR1 CNKSR1 CYFIP1 CYFIP1 CB3H15orf62 CB3H15orf62 RAPGEFL1 RAPGEFL1 WAS WAS LAT LAT KRAS KRAS WASF1 WASF1 RHOJ RHOJ RANGRF RANGRF RHOA RHOA RAB12 RAB12 M3WUK9_FELCA M3WUK9_FELCA RALA RALA COL1A2 COL1A2 RAB9A RAB9A KPNB1 KPNB1 RALB RALB CCNA2 CCNA2 RHOV RHOV CDKN1A CDKN1A SHTN1 SHTN1 RRAS RRAS RAP2C RAP2C JUN JUN RAP1A RAP1A EPS8L1 EPS8L1 ARHGAP5 ARHGAP5 CTNNAL1 CTNNAL1 DOK3 DOK3 SOS1 SOS1 LOC101100956 LOC101100956 RASGRF2 RASGRF2 GNA13 GNA13 RASGEF1B RASGEF1B LOC101096707 LOC101096707 CDC42EP3 CDC42EP3 CDC42-2 CDC42-2 RB1 RB1 SOS2 SOS2 RAP1B RAP1B M3XEZ6_FELCA M3XEZ6_FELCA ARHGEF12 ARHGEF12 NCKAP1 NCKAP1 TAX1BP3 TAX1BP3 RAB4A RAB4A RASGEF1C RASGEF1C ARHGDIA ARHGDIA CDC42EP4 CDC42EP4 RAB33A RAB33A RAB39B RAB39B RABGEF1 RABGEF1 ZNF304 ZNF304 CDK2 CDK2 RAB30 RAB30 ARHGDIB ARHGDIB NRAS NRAS NISCH NISCH RAB21 RAB21 RAB39A RAB39A MAPKAPK5 MAPKAPK5 RAB33B RAB33B KIAA0355 KIAA0355 ENSFCAP00000036118 ENSFCAP00000036118 RAPGEF4 RAPGEF4 ROCK1 ROCK1 RHOU RHOU RAPGEF3 RAPGEF3 RAPGEF1 RAPGEF1 MRAS MRAS RIT1 RIT1 RASSF1 RASSF1 RFXANK RFXANK CDC42EP5 CDC42EP5 PPP1R21 PPP1R21 ENSFCAP00000042846 ENSFCAP00000042846 EPS8 EPS8 RALGDS RALGDS DNMT1 DNMT1 ARHGAP35 ARHGAP35 NGFR NGFR RASGRP2 RASGRP2 RAPGEF2 RAPGEF2 DGKI DGKI TP53 TP53 RAP2A RAP2A NKIRAS2 NKIRAS2 RASGEF1A RASGEF1A USP8 USP8 SYNJ2BP SYNJ2BP GNA12 GNA12 SYNGAP1 SYNGAP1 RAB15 RAB15 SGSM3 SGSM3 GPSM2 GPSM2 PHACTR4 PHACTR4 RAC3 RAC3 RIPOR1 RIPOR1 ADGRG1 ADGRG1 RAB35 RAB35 RASGRF1 RASGRF1 EPS8L2 EPS8L2 RASGRP1 RASGRP1 NF1 NF1 DOK2 DOK2 RAC2 RAC2 RAB4B RAB4B RERG RERG CELSR1 CELSR1 NKIRAS1 NKIRAS1 ROCK2 ROCK2 ARHGDIG ARHGDIG RAPGEF5 RAPGEF5 EPS8L3 EPS8L3 RAC1 RAC1 AIF1 AIF1 ARHGEF11 ARHGEF11 DBNL DBNL CDC42EP1 CDC42EP1 ENSFCAP00000061258 ENSFCAP00000061258 THAP2 THAP2 PDIA2 PDIA2 TRIM28 TRIM28 ERAS ERAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (930 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
BRAPBRCA1 associated protein. (592 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1132 aa)
RASGRP4RAS guanyl releasing protein 4. (671 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2162 aa)
CDC42EP2Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (214 aa)
KSR2Kinase suppressor of ras 2. (949 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1112 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RHOGRas homolog family member G. (191 aa)
CDH13Cadherin 13. (713 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
ELMO1Engulfment and cell motility 1. (742 aa)
CDC42Uncharacterized protein. (191 aa)
RGL3Ral guanine nucleotide dissociation stimulator like 3. (716 aa)
RAP2BRAP2B, member of RAS oncogene family. (183 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1630 aa)
BCL6BCL6 transcription repressor. (745 aa)
DOK1Docking protein 1. (493 aa)
PDPNPodoplanin. (163 aa)
WASF2WASP family member 2. (498 aa)
USP50Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (372 aa)
HACD3Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (362 aa)
RALGPS1Ral GEF with PH domain and SH3 binding motif 1. (557 aa)
KSR1Kinase suppressor of ras 1. (928 aa)
RACGAP1Rac GTPase activating protein 1. (668 aa)
RRAS2Uncharacterized protein. (204 aa)
RASGRP3RAS guanyl releasing protein 3. (692 aa)
RIT2Ras like without CAAX 2. (217 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (569 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
GDI1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (447 aa)
RALGPS2Ral GEF with PH domain and SH3 binding motif 2. (583 aa)
RHOHRas homolog family member H. (191 aa)
RGL1Ral guanine nucleotide dissociation stimulator like 1. (873 aa)
CNKSR1Connector enhancer of kinase suppressor of Ras 1. (722 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
CB3H15orf62Chromosome B3 C15orf62 homolog. (175 aa)
RAPGEFL1Rap guanine nucleotide exchange factor like 1. (662 aa)
WASWASP actin nucleation promoting factor. (501 aa)
LATLinker for activation of T cells. (231 aa)
KRASUncharacterized protein. (380 aa)
WASF1WASP family member 1. (570 aa)
RHOJRas homolog family member J. (236 aa)
RANGRFUncharacterized protein. (186 aa)
RHOARas homolog family member A. (193 aa)
RAB12RAB12, member RAS oncogene family. (339 aa)
M3WUK9_FELCAUncharacterized protein. (166 aa)
RALARAS like proto-oncogene A. (206 aa)
COL1A2Collagen type I alpha 2 chain. (1367 aa)
RAB9ARAB9A, member RAS oncogene family. (201 aa)
KPNB1Karyopherin subunit beta 1. (876 aa)
RALBRAS like proto-oncogene B. (206 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
RHOVRas homolog family member V. (236 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
SHTN1Shootin 1. (631 aa)
RRASRAS related. (218 aa)
RAP2CRAP2C, member of RAS oncogene family. (183 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
EPS8L1EPS8 like 1. (777 aa)
ARHGAP5Rho GTPase activating protein 5. (1503 aa)
CTNNAL1Catenin alpha like 1. (728 aa)
DOK3Docking protein 3. (447 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
LOC101100956Uncharacterized protein. (129 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1239 aa)
GNA13G protein subunit alpha 13. (377 aa)
RASGEF1BRasGEF domain family member 1B. (652 aa)
LOC101096707Death domain-containing protein. (220 aa)
CDC42EP3CDC42 effector protein 3. (254 aa)
CDC42-2Uncharacterized protein. (191 aa)
RB1RB transcriptional corepressor 1. (930 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
RAP1BRAP1B, member of RAS oncogene family. (187 aa)
M3XEZ6_FELCAUncharacterized protein. (183 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1543 aa)
NCKAP1NCK associated protein 1. (1134 aa)
TAX1BP3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
RAB4AUncharacterized protein. (454 aa)
RASGEF1CRasGEF domain family member 1C. (466 aa)
ARHGDIAUncharacterized protein. (425 aa)
CDC42EP4CDC42 effector protein 4. (279 aa)
RAB33ARAB33A, member RAS oncogene family. (237 aa)
RAB39BRAB39B, member RAS oncogene family. (213 aa)
RABGEF1Uncharacterized protein. (491 aa)
ZNF304Zinc finger protein 304. (612 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
RAB30RAB30, member RAS oncogene family. (203 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (200 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
NISCHNischarin. (516 aa)
RAB21RAB21, member RAS oncogene family. (222 aa)
RAB39ARAB39A, member RAS oncogene family. (217 aa)
MAPKAPK5MAPK activated protein kinase 5. (473 aa)
RAB33BUncharacterized protein. (488 aa)
KIAA0355KIAA0355. (1069 aa)
ENSFCAP00000036118Uncharacterized protein. (125 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
RHOURas homolog family member U. (326 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1270 aa)
MRASMuscle RAS oncogene homolog. (254 aa)
RIT1Ras like without CAAX 1. (220 aa)
RASSF1Ras association domain family member 1. (344 aa)
RFXANKRegulatory factor X associated ankyrin containing protein. (339 aa)
CDC42EP5CDC42 effector protein 5. (153 aa)
PPP1R21Protein phosphatase 1 regulatory subunit 21. (992 aa)
ENSFCAP00000042846Uncharacterized protein. (204 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (821 aa)
RALGDSUncharacterized protein. (885 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1710 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
NGFRNerve growth factor receptor. (421 aa)
RASGRP2RAS guanyl releasing protein 2. (615 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1700 aa)
DGKIDiacylglycerol kinase. (1082 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (518 aa)
RAP2ARAP2A, member of RAS oncogene family. (183 aa)
NKIRAS2Uncharacterized protein. (41 aa)
RASGEF1ARasGEF domain family member 1A. (488 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1116 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
GNA12G protein subunit alpha 12. (382 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1345 aa)
RAB15Uncharacterized protein. (425 aa)
SGSM3Small G protein signaling modulator 3. (805 aa)
GPSM2G protein signaling modulator 2. (767 aa)
PHACTR4Phosphatase and actin regulator. (752 aa)
RAC3Rac family small GTPase 3. (205 aa)
RIPOR1RHO family interacting cell polarization regulator 1. (1269 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (689 aa)
RAB35Uncharacterized protein. (340 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1312 aa)
EPS8L2EPS8 like 2. (748 aa)
RASGRP1RAS guanyl releasing protein 1. (877 aa)
NF1Neurofibromin 1. (2856 aa)
DOK2Docking protein 2. (463 aa)
RAC2Rac family small GTPase 2. (234 aa)
RAB4BUncharacterized protein. (234 aa)
RERGRAS like estrogen regulated growth inhibitor. (246 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3085 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (289 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1471 aa)
ARHGDIGRho GDP dissociation inhibitor gamma. (252 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (889 aa)
EPS8L3EPS8 like 3. (594 aa)
RAC1Rac family small GTPase 1. (221 aa)
AIF1Allograft inflammatory factor 1. (157 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1657 aa)
DBNLDrebrin like. (522 aa)
CDC42EP1CDC42 effector protein 1. (525 aa)
ENSFCAP00000061258Uncharacterized protein. (170 aa)
THAP2Transmembrane protein 19. (348 aa)
PDIA2Protein disulfide isomerase family A member 2. (523 aa)
TRIM28Tripartite motif containing 28. (821 aa)
ERASES cell expressed Ras. (233 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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