STRINGSTRING
SPO11 SPO11 WNT9B WNT9B FSHR FSHR SGPL1 SGPL1 COL9A3 COL9A3 NANOG NANOG CCDC182 CCDC182 KLHL10 KLHL10 STAT5B STAT5B CSMD2 CSMD2 HSD17B3 HSD17B3 MAS1 MAS1 KIT KIT TBC1D20 TBC1D20 CHD7 CHD7 NIPBL NIPBL PRDX4 PRDX4 LGR4 LGR4 SYCP2 SYCP2 TFAP2C TFAP2C AMHR2 AMHR2 FOXF2 FOXF2 CRKL CRKL LRP2 LRP2 DMRT1 DMRT1 AR AR EIF2B5 EIF2B5 NRIP1 NRIP1 MERTK MERTK HNF4A HNF4A HSD17B4 HSD17B4 GREB1 GREB1 LFNG LFNG NKX2-2 NKX2-2 PDGFRA PDGFRA LHCGR LHCGR KDR KDR GATA1 GATA1 SLIT3 SLIT3 SAFB2 SAFB2 NUPR1 NUPR1 TYRO3 TYRO3 NUP107 NUP107 TIPARP TIPARP ADAMTS1 ADAMTS1 MSH2 MSH2 DMRTA1 DMRTA1 GATA4 GATA4 MSH4 MSH4 DACH1 DACH1 YBX3 YBX3 SALL1 SALL1 NR0B1 NR0B1 LOC101088229 LOC101088229 ATRX ATRX RUSC1 RUSC1 LOC101084379 LOC101084379 RDH10 RDH10 REC8 REC8 EIF2S2 EIF2S2 ING2 ING2 BRCA2 BRCA2 OSR1 OSR1 H3F3A H3F3A ESR1 ESR1 TMF1 TMF1 TCF21 TCF21 AFP AFP WDR48 WDR48 BMP15 BMP15 NHLH2 NHLH2 HESX1 HESX1 FGF9 FGF9 CITED2 CITED2 FOXO3 FOXO3 GPR149 GPR149 ASPM ASPM ATN1 ATN1 TNFAIP6 TNFAIP6 UBE3A UBE3A GATA6 GATA6 BMPR1A BMPR1A BMP6 BMP6 HOXD13 HOXD13 EIF2B2 EIF2B2 KIF18A KIF18A ATM ATM DMRT3 DMRT3 ENSFCAP00000027236 ENSFCAP00000027236 SIRT1 SIRT1 TP63 TP63 CSMD1 CSMD1 SF1 SF1 PTPN11 PTPN11 GAS2 GAS2 SMAD4 SMAD4 FZD4 FZD4 FGF10 FGF10 NKX2-1 NKX2-1 FST FST VGF VGF SFRP1 SFRP1 AXL AXL STRA6 STRA6 SPATA2 SPATA2 HOXA11 HOXA11 LHX9 LHX9 PATZ1 PATZ1 SOX8 SOX8 BMPR1B BMPR1B LHX1 LHX1 SFRP2 SFRP2 NR5A2 NR5A2 SLIT2 SLIT2 GREB1L GREB1L ADAM20 ADAM20 ERCC1 ERCC1 LOC101094201 LOC101094201 RXFP2 RXFP2 WDR19 WDR19 PCYT1B PCYT1B CBX2 CBX2 ENSFCAP00000042864 ENSFCAP00000042864 HYAL3 HYAL3 WT1 WT1 IRX5 IRX5 DMRTA2 DMRTA2 TIFAB TIFAB GATA3 GATA3 ARID4A ARID4A ENSFCAP00000044777 ENSFCAP00000044777 ADAM29 ADAM29 BCL2L2 BCL2L2 FANCA FANCA EIF2B4 EIF2B4 INHBA INHBA WNT2B WNT2B DMRTB1 DMRTB1 DHH DHH FANCG FANCG DMRT2 DMRT2 SOX9 SOX9 NHLH1 NHLH1 GALK1 GALK1 TGFBR1 TGFBR1 IMMP2L IMMP2L GFRA1 GFRA1 TBX3 TBX3 RPS19 RPS19 NR5A1 NR5A1 CEBPB CEBPB BCL2L11 BCL2L11 RAB13 RAB13 SRD5A2 SRD5A2 HOXA9 HOXA9 PTX3 PTX3 HOXA13 HOXA13 SIX4 SIX4 ASB1 ASB1 ADGRG1 ADGRG1 NKX3-1 NKX3-1 LOC101087152 LOC101087152 LRRC6 LRRC6 STAT5A STAT5A TAF4 TAF4 NEUROG1 NEUROG1 AMH AMH FOXL2 FOXL2 SRD5A1 SRD5A1 SCAPER SCAPER BIK BIK PKD1 PKD1 ENSFCAP00000059307 ENSFCAP00000059307 BAK1 BAK1 DHCR24 DHCR24 DMC1 DMC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPO11SPO11 initiator of meiotic double stranded breaks. (396 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (692 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (671 aa)
COL9A3Collagen type IX alpha 3 chain. (681 aa)
NANOGNanog homeobox. (311 aa)
CCDC182Coiled-coil domain containing 182. (153 aa)
KLHL10Kelch like family member 10. (608 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
CSMD2CUB and Sushi multiple domains 2. (3632 aa)
HSD17B3Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (306 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (979 aa)
TBC1D20TBC1 domain family member 20. (403 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2995 aa)
NIPBLNipped-B protein. (2805 aa)
PRDX4Peroxiredoxin 4. (306 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
SYCP2Synaptonemal complex protein 2. (1373 aa)
TFAP2CTranscription factor AP-2 gamma. (546 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (483 aa)
FOXF2Forkhead box F2. (449 aa)
CRKLCRK like proto-oncogene, adaptor protein. (342 aa)
LRP2LDL receptor related protein 2. (4646 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (378 aa)
ARAndrogen receptor. (903 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (729 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
MERTKMER proto-oncogene, tyrosine kinase. (994 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (736 aa)
GREB1Growth regulating estrogen receptor binding 1. (1943 aa)
LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (556 aa)
NKX2-2NK2 homeobox 2. (273 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa)
GATA1GATA binding protein 1. (413 aa)
SLIT3Slit guidance ligand 3. (1530 aa)
SAFB2Scaffold attachment factor B2. (1048 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
TYRO3TYRO3 protein tyrosine kinase. (889 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (925 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (692 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (966 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
DMRTA1DMRT like family A1. (494 aa)
GATA4GATA binding protein 4. (443 aa)
MSH4DNA_MISMATCH_REPAIR_2 domain-containing protein. (935 aa)
DACH1Dachshund family transcription factor 1. (711 aa)
YBX3Y-box binding protein 3. (361 aa)
SALL1Spalt like transcription factor 1. (1238 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (471 aa)
LOC101088229Uncharacterized protein. (669 aa)
ATRXATRX chromatin remodeler. (2486 aa)
RUSC1RUN and SH3 domain containing 1. (907 aa)
LOC101084379Homeobox domain-containing protein. (290 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
REC8REC8 meiotic recombination protein. (563 aa)
EIF2S2Eukaryotic translation initiation factor 2 subunit beta. (333 aa)
ING2Inhibitor of growth protein. (280 aa)
BRCA2Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...] (3375 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
H3F3AHistone H3; Belongs to the histone H3 family. (136 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
TMF1TATA element modulatory factor 1. (1093 aa)
TCF21Transcription factor 21. (179 aa)
AFPAlpha fetoprotein. (609 aa)
WDR48WD repeat domain 48. (677 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
NHLH2Nescient helix-loop-helix 2. (135 aa)
HESX1HESX homeobox 1. (207 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
FOXO3Forkhead box O3. (672 aa)
GPR149G protein-coupled receptor 149. (747 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3478 aa)
ATN1Atrophin 1. (1193 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (834 aa)
GATA6GATA binding protein 6. (646 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMP6Bone morphogenetic protein 6. (502 aa)
HOXD13Homeobox D13. (341 aa)
EIF2B2Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (403 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (896 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (477 aa)
ENSFCAP00000027236Uncharacterized protein. (708 aa)
SIRT1Sirtuin 1. (745 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CSMD1CUB and Sushi multiple domains 1. (3501 aa)
SF1Splicing factor 1. (670 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
GAS2Growth arrest specific 2. (314 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
NKX2-1NK2 homeobox 1. (399 aa)
FSTFollistatin. (423 aa)
VGFVGF nerve growth factor inducible. (616 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
AXLAXL receptor tyrosine kinase. (861 aa)
STRA6Stimulated by retinoic acid 6. (700 aa)
SPATA2Spermatogenesis associated 2. (520 aa)
HOXA11Homeobox A11. (327 aa)
LHX9LIM homeobox 9. (487 aa)
PATZ1POZ/BTB and AT hook containing zinc finger 1. (687 aa)
SOX8SRY-box 8. (883 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (588 aa)
LHX1LIM homeobox 1. (406 aa)
SFRP2Secreted frizzled related protein 2. (385 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1969 aa)
ADAM20ADAM metallopeptidase domain 20. (729 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (329 aa)
LOC101094201SCHIP-1 domain-containing protein. (489 aa)
RXFP2Relaxin family peptide receptor 2. (713 aa)
WDR19WD repeat domain 19. (1342 aa)
PCYT1BPhosphate cytidylyltransferase 1, choline, beta. (427 aa)
CBX2Chromobox 2. (529 aa)
ENSFCAP00000042864Uncharacterized protein. (787 aa)
HYAL3Hyaluronidase. (419 aa)
WT1WT1 transcription factor. (523 aa)
IRX5Iroquois homeobox 5. (483 aa)
DMRTA2DMRT like family A2. (535 aa)
TIFABTIFA inhibitor. (214 aa)
GATA3GATA binding protein 3. (444 aa)
ARID4AAT-rich interaction domain 4A. (1278 aa)
ENSFCAP00000044777Uncharacterized protein. (321 aa)
ADAM29ADAM metallopeptidase domain 29. (960 aa)
BCL2L2BCL2 like 2. (193 aa)
FANCAFA complementation group A. (1476 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (545 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity). (424 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
DMRTB1DMRT like family B with proline rich C-terminal 1. (386 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
FANCGFA complementation group G. (626 aa)
DMRT2Doublesex and mab-3 related transcription factor 2. (560 aa)
SOX9SRY-box transcription factor 9. (511 aa)
NHLH1Nescient helix-loop-helix 1. (133 aa)
GALK1Galactokinase 1. (619 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
IMMP2LMitochondrial inner membrane protease subunit. (175 aa)
GFRA1GDNF family receptor alpha 1. (509 aa)
TBX3T-box transcription factor 3. (745 aa)
RPS19DMRT like family C2. (673 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
RAB13Uncharacterized protein. (203 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
PTX3Pentraxin 3. (381 aa)
HOXA13Homeobox A13. (389 aa)
SIX4SIX homeobox 4. (784 aa)
ASB1Ankyrin repeat and SOCS box containing 1. (400 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (689 aa)
NKX3-1NK3 homeobox 1. (231 aa)
LOC101087152Uncharacterized protein. (773 aa)
LRRC6Leucine rich repeat containing 6. (476 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
TAF4TATA-box binding protein associated factor 4. (1099 aa)
NEUROG1Neurogenin 1. (243 aa)
AMHAnti-Mullerian hormone. (800 aa)
FOXL2Forkhead box L2. (357 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (288 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1401 aa)
BIKUncharacterized protein. (245 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4299 aa)
ENSFCAP00000059307Uncharacterized protein. (766 aa)
BAK1BCL2 antagonist/killer 1. (251 aa)
DHCR2424-dehydrocholesterol reductase. (571 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (348 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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